Orally disintegrating tablet containing ezetimibe and preparation method of orally disintegrating tablet

A technology of oral disintegrating tablet and ezetimibe, which is applied in the field of ezetimibe oral disintegrating tablet and preparation thereof

Inactive Publication Date: 2015-02-11
万全万特制药江苏有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides an orally disintegrating ezetimibe tablet, which improves the dissolution rate of ezetim...

Method used

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  • Orally disintegrating tablet containing ezetimibe and preparation method of orally disintegrating tablet
  • Orally disintegrating tablet containing ezetimibe and preparation method of orally disintegrating tablet
  • Orally disintegrating tablet containing ezetimibe and preparation method of orally disintegrating tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Preparation of ezetimibe orally disintegrating tablets

[0020] Each tablet contains 10mg of ezetimibe, and its prescription is:

[0021]

[0022] Preparation Process:

[0023] (1) Pass filler, disintegrant, flavoring agent, binder and lubricant through a 100-mesh sieve; ezetimibe through a 60-mesh sieve;

[0024] (2) Co-crushing ezetimibe and filler;

[0025] (3) Mix the pulverized product of ezetimibe and filler with disintegrant and flavoring agent, add binder to granulate, dry at 50°C, add lubricant, and press into tablets to obtain ezetimibe Orally disintegrating tablet.

[0026] Each ezetimibe orally disintegrating tablet contains 10 mg of ezetimibe, weighs 100 mg, and has a hardness of 20N to 30N.

Embodiment

[0027] Example 2 Preparation of ezetimibe orally disintegrating tablets

[0028]

[0029] Preparation Process:

[0030] (1) Pass filler, disintegrant, flavoring agent, binder and lubricant through a 100-mesh sieve; ezetimibe through a 60-mesh sieve;

[0031] (2) Co-crushing ezetimibe and filler;

[0032] (3) Mix the pulverized product of ezetimibe and filler with disintegrant and flavoring agent, add binder to granulate, dry at 50°C, add lubricant, and press into tablets to obtain ezetimibe Orally disintegrating tablet.

[0033] Each ezetimibe orally disintegrating tablet contains 10 mg of ezetimibe, weighs 100 mg, and has a hardness of 20N to 30N.

[0034] Example 3 Preparation of ezetimibe orally disintegrating tablets

[0035]

[0036] Preparation Process:

[0037] (1) Pass filler, disintegrant, flavoring agent, binder and lubricant through a 100-mesh sieve; ezetimibe through a 60-mesh sieve;

[0038] (2) Co-crushing ezetimibe and filler;

[0039] (3) Mix t...

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Abstract

The invention relates to an orally disintegrating tablet containing a cholesterol absorption inhibitor ezetimibe and a preparation method of the orally disintegrating tablet. With ezetimibe as an active component, auxiliary components such as a filling agent, a disintegrating agent, an adhesive, a flavoring agent and a lubricating agent are added. The orally disintegrating tablet containing ezetimibe to which the invention relates is simple in preparation process and good in mouthfeel; compared with listed products at present, the orally disintegrating tablet is suitable for being taken by special people, such as old people and patients with dysphagia.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an orally disintegrating ezetimibe tablet and a preparation method thereof, which are used for primary hypercholesterolemia, and the product is used as an auxiliary treatment other than diet control. Background technique [0002] Clinical studies have shown that dyslipidemia is one of the important risk factors for coronary heart disease, atherosclerosis and other cardiovascular and cerebrovascular diseases. Hyperlipidemia refers to high blood cholesterol and / or triglycerides or low high-density lipoprotein cholesterol, and its direct damage is to cause systemic atherosclerosis. In addition, hyperlipidemia is also an important risk factor for high blood pressure, impaired glucose tolerance, and diabetes. It can also lead to fatty liver, cirrhosis, cholelithiasis, pancreatitis, fundus hemorrhage, blindness, peripheral vascular disease, claudication, and hyperuricemia. . ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/397A61P3/06
Inventor 刘睿昊刁媛媛马苏峰
Owner 万全万特制药江苏有限公司
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