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A traditional Chinese medicine perfusate for promoting uterine contraction and content discharge of sows and its application

The technology of uterine contraction and perfusion is applied in the field of traditional Chinese medicine perfusion to promote the uterine contraction of sows and the discharge of contents, which can solve the problems of high intensity of action, narrow application range of oxytocin, and influence on normal reproduction and production of sows. To achieve the effect of promoting excretion and preventing endometritis

Active Publication Date: 2017-05-10
HUNAN TAIFENG ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Under modern production management conditions, sows face many problems during and after delivery, such as the increase in the proportion of dystocia due to factors such as long-term lack of exercise, oversized fetuses, and sow constipation. , uterine weakness, etc. cause postpartum retention of placenta, fetal retention in the uterus, endless lochia, etc., which increase the risk of endometritis. In fact, many sows suffer from latent endometritis due to postpartum infection, which is harmful to sows. normal reproduction and production of
[0005] When a sow has dystocia, the customary method is to induce labor by intramuscular or intravenous injection of oxytocin, but the scope of application of oxytocin is relatively narrow, it only acts on the contraction of the uterus, and the action intensity is strong and the action time is short. Dystocia due to immature cervix, narrow birth canal, and too large fetus is not suitable for midwifery with oxytocin. In clinical practice, there are many stillbirths caused by misuse of oxytocin
[0006] The traditional method for postpartum infection is to flush the uterus with antibiotics, etc., but it is difficult to do so because of the special structure of the uterus and the problem of local drug residues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Accurately weigh and air-dry 250g of Hedyotis diffusa 250g, 250g of Desmodium, 200g of Duckweed, 120g of cassava, and 300g of Hedyotis diffusa, chop them up and mix them through an 80-mesh sieve, put them into an ultrasonic container, add 15kg of absolute ethanol Extract under ultrasonic state for 1h, ultrasonic power 40W, filter, the filtrate is evaporated and dried at 50°C until the mass is 3%-5% of the original drug, to obtain the extract, weigh the quality of the extract, and prepare 14 times the mass of the extract in addition normal saline and dehydrated alcohol weighing 6 times the quality of the extract to prepare a dilution solution, put the extract into the dilution solution, fully dissolve and shake well to obtain the perfusion solution, and use 100ml glassware to subpackage the perfusion solution. Seal it, steam sterilize it at 105°C for 10 minutes, and leave it to cool to get the finished product.

Embodiment 2

[0027] Accurately weigh and air-dry 300g of ghost needle grass, 300g of money grass, 250g of duck grass, 100g of cassava, and 400g of hedyotis diffusa, chop them up and mix them through an 80-mesh sieve, put them into an ultrasonic container, add 25kg of absolute ethanol Extract under ultrasonic state for 2h, ultrasonic power 40W, filter, the filtrate is evaporated and dried at 50°C until the mass is 3%-5% of the original drug, and the extract is obtained, and the mass of the extract is weighed, and 40 times the mass of the extract is prepared in addition normal saline and absolute ethanol weighing 10 times the quality of the extract to prepare a dilution solution, put the extract into the dilution solution, fully dissolve and shake well to obtain the perfusion solution, and use 100ml glassware to subpackage the perfusion solution. Seal it, steam sterilize it at 105°C for 10 minutes, and leave it to cool to get the finished product.

Embodiment 3

[0029] Contraction of perfusate on isolated mouse uterus

[0030] 1. Experimental method: kill a group of young mice after inducing estrus, separate the uterine horns and cut off 1cm long fragments, place them in a tissue bath filled with 10ml buffer solution, add the perfusate of the present invention in the container, Observe the strength and frequency of uterine contractions, and record them with a load cell. Acetylcholine is used as a positive control, and ethanol is used as a blank control.

[0031] 2. Experimental results:

[0032] As a result, it was not observed that ethanol could cause uterine contraction, but the perfusate of the present invention caused obvious contraction of mouse uterine tissue, and the contraction intensity was 23% higher than that of acetylcholine, and the frequency was increased by 56%.

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PUM

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Abstract

The invention discloses traditional Chinese medicine perfusate for promoting uterine contraction and excretion discharge of sows and an application thereof. The preparation method comprises the following steps: evaporating and drying alcohol extracts of 150-410 parts of sticktight, 150-410 parts of Lysimachia christinae Hance, 120-350 parts of commeline communis, 80-230 parts of cassava and 210-450 parts of Oldenlandia diffusa, and dissolving the extracts in specific diluent. The Chinese herbal medicine extract accounts for 2-5 mass percent of the perfusate, the perfusate is used for uterine perfusion of the sows, 50-100ml of perfusate is perfused each time, and the perfusate can achieve positive treatment effects on symptoms such as dystocia, retained fetal membranes, fetal intrauterine retention of countless postpartum lochia and uterus inflammation of the sows. The traditional Chinese medicine perfusate is exact in effect and safe, has wider application range than the common pitocin and does not have any side effect.

Description

[0001] Technical field: [0002] The invention belongs to the field of application of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine perfusate for promoting uterine contraction and excretion of contents in sows and an application method thereof. [0003] Background technique: [0004] Under modern production management conditions, sows face many problems during and after delivery, such as the increase in the proportion of dystocia due to factors such as long-term lack of exercise, oversized fetuses, and sow constipation. , uterine weakness, etc. cause postpartum retention of placenta, fetal retention in the uterus, endless lochia, etc., which increase the risk of endometritis. In fact, many sows suffer from latent endometritis due to postpartum infection, which is harmful to sows. The normal reproduction and production have a great impact. [0005] When a sow has dystocia, the customary method is to induce labor by intramuscular or i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/748A61P15/04A61P15/00
CPCA61K9/0034A61K9/08A61K36/185A61K36/28A61K36/47A61K36/53A61K36/748A61K2236/33A61K2300/00
Inventor 禹善秋
Owner HUNAN TAIFENG ANIMAL PHARMA
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