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An extract capable of assisting in lowering blood sugar and blood fat and its preparation method

An extract and a blood lipid-lowering technology are applied in the field of preparation of extracts extracted from partridge tea, which can assist in lowering blood sugar and blood lipid, and achieve the effects of safe and stable quality, pleasant taste, and simple and controllable production process.

Active Publication Date: 2018-04-13
BIO-BANK CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, at present, there are no relevant research reports on the activity of partridge tea in lowering blood sugar and blood lipids at home and abroad. The present invention studies the extraction process of partridge tea and detects the activities of lowering blood sugar and blood lipids of its extracts, aiming to obtain Extracts for the prevention or treatment of chronic diseases such as hyperglycemia and hyperlipidemia, and lay the foundation for the research on the biological activity of partridge tea, and provide scientific basis for better research, development and utilization of partridge tea plant resources

Method used

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  • An extract capable of assisting in lowering blood sugar and blood fat and its preparation method
  • An extract capable of assisting in lowering blood sugar and blood fat and its preparation method
  • An extract capable of assisting in lowering blood sugar and blood fat and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Preparation of Extract

[0017] A large amount of partridge tea leaves were collected, carefully selected, and naturally dried in the shade. After crushing, 15 kg of dry leaves were crushed and sieved through a 40-mesh sieve. They were divided into three batches of 5 kg per batch and decocted in water at a volume ratio of 1:10. Batch samples were decocted 3 times, 2 h each time.

[0018] Combining water and decocting the obtained extract, filtering to obtain the filtrate, and concentrating the filtrate to a paste, which is 2.1 kg of partridge tea extract.

[0019] Take 10 kg of macroporous adsorption resin type D101, soak in an appropriate amount of 2% sodium hydroxide for 2 h, wash off with a large amount of distilled water until the pH is neutral, add 95% ethanol to soak for 1 h, wash off, and set aside.

[0020] Take 2 kg of water to extract the extract, dissolve it with an appropriate amount of water, slowly pour it into a macroporous adsorption resin chr...

Embodiment 2

[0025] Example 2 Experiment of lowering blood sugar in mice

[0026] Observe the effect of the extract of the present invention on the blood sugar level of diabetic mice.

[0027] Tested drug: partridge tea auxiliary hypoglycemic extract was prepared from the above-mentioned Example 1, and was respectively prepared into a solution with a concentration of 500 mg / L in water.

[0028] Modeling agent: Streptozocin (STZ), Sigma Company. Use 0.1 mol / L, pH 4.2 sodium citrate buffer to freshly prepare (operate on ice) into a solution with a concentration of 13.0 mg / mL.

[0029] Animals: Kunming white mice 20±2 g, SPF grade, male, provided by the Animal Center of the Institute of Medicinal Botany, Chinese Academy of Medical Sciences. Adaptive feeding was carried out for 7 days in the animal room under the conditions of temperature 22°C and relative humidity 60%.

[0030] Animal grouping: the mice were randomly divided into 7 groups, blank control group, model control group, and the ...

Embodiment 3

[0039] Example 3 Blood lipid lowering experiment

[0040] Observe the effect of the extract of the present invention on the cholesterol level of mice with hyperlipidemia.

[0041] Tested drug: partridge tea auxiliary hypoglycemic extract was prepared from the above-mentioned Example 1, and was respectively prepared into a solution with a concentration of 500 mg / L in water.

[0042] Composition of high-fat feed: basic feed (flour 25, cornmeal 20, oatmeal 25, bean cake powder 12, fish meal 8, bone meal 2, yeast powder 2, refined salt 1) 83.4%, egg yolk powder 10%, lard 5%, sodium cholate 0.5%, ,0.1% Methimazole, 1% Cholesterol.

[0043] Animals: Kunming white mice 22±3 g, SPF grade, male, provided by the Animal Center of the Institute of Medicinal Botany, Chinese Academy of Medical Sciences. Adaptive feeding was carried out for 7 days in the animal room under the conditions of temperature 22°C and relative humidity 60%.

[0044] Animal grouping: the mice were randomly divided...

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Abstract

The invention discloses an extract capable of assisting in lowering blood sugar and blood fat and a preparation method thereof, and relates to the fields of health food, functional food, new resource food and the like. It is mainly made from partridge tea leaves through selection, decoction, concentration, elution with macroporous adsorption resin, and drying. The pharmacodynamic experiments of the extract of the present invention show that the partridge tea extract has the function of assisting in lowering blood sugar and blood fat, and has high safety, good water solubility, strong tea fragrance, pleasant taste, and is convenient to take or eat. It can be made into various dosage forms such as capsules, tablets, oral liquids or granules, and can also be prepared into foods such as herbal teas, beverages, and candies. The preparation method of the hypoglycemic and hypolipidemic extract provided by the invention has the advantages of simple production process, controllable quality, safety and stability.

Description

technical field [0001] The invention belongs to the fields of health food, functional food, new resource food, etc., and specifically relates to a preparation method and application of an extract from partridge tea that can assist in lowering blood sugar and blood fat. Background technique [0002] Partridge Tea ( Mallotus furetianus ), also known as Shankucha, is a plant of the Euphorbiaceae (Euphorbiaceae) Mallotus Lour., which has a history of eating for thousands of years in Hainan. It is mainly distributed in the mountains, hills and coastal areas of Hainan, especially in Wanning Dongshanling is the most prosperous, and it is a kind of tea-substituting beverage plant and medicinal plant with very national and regional characteristics in Hainan. Partridge tea is round and sweet, and it is a peculiar wild tea. This tea is sweet and refreshing, and has a pleasant medicinal fragrance. It has the effects of clearing heat and detoxifying, eliminating food and gallbladder, l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23F3/16A61K36/47A61P3/06A61P3/10A23L33/00
Inventor 陈德力刘洋洋马国需赵祥升弓宝魏建和许旭东
Owner BIO-BANK CORP
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