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Preparation method of magnetic chitosan nanoparticles and application of magnetic chitosan microspheres

A technology of chitosan microspheres and magnetic nanometers, which is applied in the field of nanocomposite material preparation, can solve problems such as difficult control of the particle size distribution of contrast agents, improve diagnostic imaging effects, reduce in vivo toxicity, and increase transverse relaxation rates Effect

Inactive Publication Date: 2015-03-25
ANHUI UNIVERSITY OF TECHNOLOGY AND SCIENCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the particle size distribution of the contrast agent is difficult to control, and the transverse relaxation rate value r 2 The limited improvement has aroused the enthusiasm of scientists to develop new products

Method used

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  • Preparation method of magnetic chitosan nanoparticles and application of magnetic chitosan microspheres
  • Preparation method of magnetic chitosan nanoparticles and application of magnetic chitosan microspheres
  • Preparation method of magnetic chitosan nanoparticles and application of magnetic chitosan microspheres

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A preparation method of chitosan magnetic nano microspheres, comprising the following steps:

[0028] (1), preparation of superparamagnetic iron oxide-based nanoparticles:

[0029] A mixture of 2.12 g of iron acetylacetonate and 50 ml of tetraethylene glycol was heated at 110° C. for 1 hour under stirring, and then heated and refluxed at 210° C. for 3 hours, under nitrogen protection throughout. The product was separated by ether precipitation at room temperature, washed twice with a mixture of ether and ethanol, and dried to obtain superparamagnetic Fe 3 o 4 Nanoparticles. The product particle size is about 8.8nm.

[0030] (2), chitosan microspheres tightly wrapped superparamagnetic iron oxide nanoparticle clusters:

[0031] Take 0.5 grams of water-soluble chitosan and dissolve it in 80 milliliters of distilled water, add ethylenediamine tetraacetic acid, the mass is 1 / 2 of chitosan, inject 20 milliliters after dissolving, and disperse 0.1 grams of Fe 3 o 4Aqueou...

Embodiment 2

[0034] A preparation method of chitosan magnetic nano microspheres, comprising the following steps:

[0035] (1), preparation of superparamagnetic iron oxide-based nanoparticles:

[0036] A mixture of 2.12 g of iron acetylacetonate and 50 ml of tetraethylene glycol was heated at 110° C. for 1 hour under stirring, and then heated and refluxed at 230° C. for 3 hours, under nitrogen protection throughout. The product was separated by ether precipitation at room temperature, washed twice with a mixture of ether and ethanol, and dried to obtain superparamagnetic Fe 3 o 4 Nanoparticles. The product particle size is about 8.8nm.

[0037] (2), chitosan microspheres tightly wrapped superparamagnetic iron oxide nanoparticle clusters:

[0038] Take 0.5 grams of water-soluble chitosan and dissolve it in 80 milliliters of distilled water, add ethylenediamine tetraacetic acid, the mass is 1 / 3 of chitosan, inject 20 milliliters after dissolving, and disperse 0.1 grams of Fe 3 o 4 Aqueo...

Embodiment 3

[0041] A preparation method of chitosan magnetic nano microspheres, comprising the following steps:

[0042] (1), preparation of superparamagnetic iron oxide-based nanoparticles:

[0043] A mixture of 0.7 g of manganese acetylacetonate, 1.41 g of iron acetylacetonate and 50 ml of tetraethylene glycol was heated at 110° C. for 1 hour under stirring, and then heated and refluxed at 240° C. for 3 hours, under nitrogen protection throughout. The product was separated by ether precipitation at room temperature, washed twice with a mixture of ether and ethanol, and dried to obtain superparamagnetic MnFe 2 o 4 Nanoparticles. The product particle size is about 6.5nm.

[0044] (2), chitosan microspheres tightly wrapped superparamagnetic iron oxide nanoparticle clusters:

[0045] Take 0.5 grams of water-soluble chitosan and dissolve it in 80 milliliters of distilled water, add ethylenediamine tetraacetic acid, the quality is 1 / 5 of chitosan, inject 20 milliliters after dissolving to...

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Abstract

The invention discloses a preparation method of magnetic chitosan nanoparticles and application of the magnetic chitosan nanoparticles. The magnetic chitosan nanoparticles are synthesized by tightly encapsulating superparamagnetic particles with water-soluble chitosan. The magnetic chitosan nanoparticles disclosed by the invention are simple, environment-friendly and fast in synthesis; the size and the magnetic-particle covering amount can be regulated and controlled; the magnetic chitosan nanoparticles have relatively high biocompatibility and stability; and considered from the size and the relaxation rate, the magnetic chitosan nanoparticles have relatively large application potential in the medical fields of early diagnosis of tumors and evaluation of image tracking curative effects as a magnetic resonance imaging contrast agent.

Description

technical field [0001] The invention relates to the preparation of a nanocomposite material, and specifically designs a preparation method and application of chitosan magnetic nanometer microspheres. Background technique [0002] Magnetic resonance imaging is a powerful diagnostic tool for noninvasive real-time detection of disease or tissue necrosis, and may be useful in the early diagnosis of lesions. Although magnetic resonance imaging technology can provide high-resolution anatomical images of soft tissues, the small difference in proton relaxation time between normal tissues and diseased parts makes it difficult for pure images to support accurate medical diagnosis. For this reason, magnetic resonance imaging contrast agents, materials that enhance image contrast, have been developed to make the contrast of imaging image details more obvious. Usually paramagnetic gadolinium complexes can shorten the proton longitudinal relaxation time T 1 , resulting in a brighter MRI...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K49/18
Inventor 林英洪艳洪柳高建刚
Owner ANHUI UNIVERSITY OF TECHNOLOGY AND SCIENCE
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