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An emulsification equipment and its application in the production of oil emulsion inactivated vaccine

A technology of emulsification equipment and inactivated vaccines, which is applied in the field of application of the equipment in the production of oil emulsion inactivated vaccines, and can solve the problems of limited emulsification capacity of emulsification equipment

Active Publication Date: 2016-11-30
乾元浩生物股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the emulsification capacity of emulsification equipment is currently limited, and the amount of emulsification in a single batch is generally only 2 million milliliters, which is difficult to further improve

Method used

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  • An emulsification equipment and its application in the production of oil emulsion inactivated vaccine
  • An emulsification equipment and its application in the production of oil emulsion inactivated vaccine
  • An emulsification equipment and its application in the production of oil emulsion inactivated vaccine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 emulsification equipment

[0033] The emulsification equipment in this example includes a water phase tank, an oil phase tank, an emulsification tank and a buffer tank connected in sequence, and an emulsification pump is arranged between the emulsification tank and the buffer tank. Such as figure 1 , 2 , shown in 3 and 4, the emulsifying tank includes an emulsifying machine, and the emulsifying machine includes a motor 14, an emulsifying head 10 and a rotating shaft 13 connecting the two, the motor 14 is located outside the emulsifying tank, and the emulsifying head 10 is located in the emulsifying tank, and the emulsifying machine There are two anti-push wheels 12 on the rotating shaft in the emulsification tank. The emulsification head includes a stator 21 and a rotor 22. The stator 22 has regularly arranged stator holes 19. There are chilled water circulation pipelines 11 on the tank outer walls of the water phase tank, oil phase tank, emulsification t...

Embodiment 2

[0041]The preparation of embodiment 2 oil emulsion inactivated vaccines

[0042] The preparation process of the present invention will be described below by taking the recombinant avian influenza virus inactivated vaccine (H5N1 subtype, Re-6 strain, purchased from Harbin Institute of Veterinary Medicine) as an example.

[0043] 1. Aqueous phase preparation: including Tween solution configuration and antigen addition.

[0044] 1.1 Configuration of Tween solution: According to the requirements of the inactivated vaccine emulsification formula, after fully mixing 110Kg of water for injection after weighing and 12Kg of Tween-80, keep it at 116°C for 40 minutes for disinfection treatment, and then use cooling water (process cycle) water and frozen water) cooled to 16-18 ℃ to make Tween solution.

[0045] 1.2 Antigen addition: add the antigen prepared in advance to the Tween solution with a peristaltic pump to make an aqueous phase. Pay attention to sterility control and antigen r...

Embodiment 3

[0051] Embodiment 3 emulsification performance comparison

[0052] 1. Comparison of emulsification time

[0053] According to the method of embodiment 2, adopt the equipment of the present invention (embodiment 1) to prepare oil emulsion, single emulsification volume is 6,000,000 milliliters.

[0054] Table 1 emulsification 6 million different emulsification time test results

[0055]

[0056] The above table shows that when emulsified to 55 minutes, the test data of the sample has met the requirements of the product regulations, so the emulsification time is set at 55 minutes. Before the modification, it took 50 minutes to emulsify a batch of 1 million ml, and 300 minutes to mix 6 million ml. Therefore, after the improvement, it only takes 55 minutes to emulsify a batch of 6 million ml, which is one-sixth of the previous emulsification time, which not only reduces energy consumption Consumption, and improve the use efficiency of equipment, but also save manpower and impr...

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PUM

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Abstract

The invention provides emulsification equipment. The emulsification equipment comprises a water phase tank, an oil phase tank, an emulsification tank and a buffering tank which are connected in sequence, wherein an emulsification pump is arranged between the emulsification tank and the buffering tank; the emulsification tank comprises an emulsification machine; the emulsification machine comprises a motor, an emulsification head and a rotary shaft for connecting the motor and the emulsification head; the motor is located outside the emulsification tank and the emulsification head is located in the emulsification tank; two reverse pushing wheels are arranged on the rotary shaft, located in the emulsification tank, of the emulsification machine; the emulsification head comprises a stator and a rotor; regularly-arrayed stator holes are formed in the stator; chilled water circulating pipelines are arranged at the outer walls of tank bodies of the water phase tank, the oil phase tank, the emulsification tank and the buffering tank; and the two ends of the chilled water circulating pipelines are connected with a chilled water circulating device by connection pipelines respectively. The invention further provides application of the emulsification equipment to the production of an oil emulsion inactivated vaccine. By virtue of the emulsification equipment, the emulsification capability can be effectively improved and the emulsification is relatively complete, fine and smooth.

Description

technical field [0001] The invention relates to the pharmaceutical field, in particular to an emulsification device, and also relates to the application of the device in the production of oil emulsion inactivated vaccines. Background technique [0002] Emulsification is the process of uniformly dispersing one liquid in another immiscible liquid as tiny droplets. Widely used in the field of cosmetics and pharmaceuticals. [0003] The mechanical equipment for preparing emulsion is mainly emulsifier, which is a kind of emulsification equipment that mixes oil and water evenly. There are three main types of emulsifier: emulsification mixer, colloid mill and homogenizer. The type, structure, and performance of the emulsifier have a great relationship with the size (dispersibility) of the emulsion particles and the quality (stability) of the emulsion. For example, the agitating emulsifier widely used in cosmetics factories has poor dispersion of the prepared emulsion. Particles ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01F7/16B01F15/06B01F3/08
Inventor 岳建新丁向东郝增轩李爱芬姚占武
Owner 乾元浩生物股份有限公司