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Recombinant Bacillus Calmette Guerin vaccine

A technology of recombinant BCG vaccine and BCG vaccine, which is applied to bacterial antigen components, antibacterial drugs, etc., can solve the problems of strong side effects of recombinant BCG vaccine and unsatisfactory BCG immune response effect, and achieve the effect of avoiding negative effects.

Inactive Publication Date: 2015-04-01
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the above deficiencies or improvement needs of the prior art, the present invention provides a recombinant BCG, the purpose of which is to obtain a "cocktail" recombinant BCG by selecting BCG that overexpresses antigens at different stages, and combining the above-mentioned BCG in a certain proportion, thereby providing Better immune activity and reduced side effects, thereby solving the technical problems of the unsatisfactory immune response of the existing BCG vaccine and the strong side effects of the existing recombinant BCG vaccine

Method used

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  • Recombinant Bacillus Calmette Guerin vaccine
  • Recombinant Bacillus Calmette Guerin vaccine
  • Recombinant Bacillus Calmette Guerin vaccine

Examples

Experimental program
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Effect test

Embodiment 1

[0033] A kind of recombinant BCG, named as ABX, the total amount of bacteria is 10 5 CFU, including 25% BCG rBCG::85A of total bacteria, 60% BCG rBCG::85B and 15% BCG rBCG::X.

Embodiment 2

[0035] A recombinant BCG, named ABX, the total amount of bacteria is 5 × 10 5 CFU, including 20% ​​BCG rBCG::85A of total bacteria, 60% BCG rBCG::85B and 20% BCG rBCG::X.

Embodiment 3

[0037] A kind of recombinant BCG, named as ABX, the total amount of bacteria is 10 6 CFU, including 33% BCG rBCG::85A of total bacteria, 34% BCG rBCG::85B and 33% BCG rBCG::X.

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Abstract

The invention discloses a recombinant Bacillus Calmette Guerin vaccine (BCG), total bacteria amount of which is between 105CFU and 106CFU. The recombinant Bacillus Calmette Guerin vaccine comprises recombinant BCG for overexpression of 85 A antigen, recombinant BCG for overexpression of 85 B antigen and recombinant BCG for overexpression of HspX antigen. By synergism of multiple bacterial strains of the recombinant BCG vaccine, the recombinant BCG vaccine has an immunoprotection function in different development phases of tuberculosis, and negative effects of mechanisms or factors such as simultaneous overexpression of multi-antigen or fusion expression, etc. on preventive effect of the BCG itself can be avoided.

Description

technical field [0001] The invention belongs to the field of biomedicine, and more specifically relates to a recombinant BCG. Background technique [0002] According to the World Health Organization (WHO), there were about 8.6 million new tuberculosis (TB) cases in 2012, including 500,000 sick children, and the rest were adult cases. A total of 1.3 million people died of TB. Moreover, there are more than 2 billion people latently infected with Mycobacterium tuberculosis (Mycobacterium tuberculosis, M.tb) in the world. In particular, the prevalence of multidrug-resistant tuberculosis (MDR-TB) and the emergence of extensively drug-resistant tuberculosis (XDR-TB) in recent years, as well as the rise of co-infection between M. One of the most threatening infectious diseases. BCG (M.bovis Bacillus Calmette-Guérin, BCG) is an attenuated live vaccine prepared from Mycobacterium bovis. At present, as the only TB preventive vaccine, the global vaccination rate of infants and young...

Claims

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Application Information

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IPC IPC(8): A61K39/04A61P31/06
Inventor 范雄林梁锦屏
Owner HUAZHONG UNIV OF SCI & TECH
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