Alginate oligomers tea polyphenol anti-radiation composite preparation

A technology of algae oligosaccharide and compound preparation, which is applied in the preparation of sugar derivatives, disaccharides, oligosaccharides, etc., to achieve the effects of good effect, prolonging survival time, and enhancing leukocyte damage defense.

Inactive Publication Date: 2015-04-22
QINGDAO BZ OLIGO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the research on the radiation resistance of alginate oligosaccharides is still blank at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A fucoidan oligosaccharide tea polyphenol anti-radiation composite preparation, the active ingredients of the composite preparation are fucoidan oligosaccharides and tea polyphenols, and the fucoidan oligosaccharides and tea polyphenols are mixed according to a weight ratio of 1:4.

[0023] The preparation method of brown algae oligosaccharides is to weigh 3g sodium alginate, add 15ml concentrated sulfuric acid in an ice water bath, stir at room temperature for about 10h, then add 80ml water in the ice water bath, and then place it in a 100℃ oil bath for condensation Reflux hydrolysis for about 1-6h. After the reaction, add anhydrous calcium carbonate powder to remove sulfuric acid until the pH is 6-7, add activated carbon for decolorization, then adjust the pH to 6-9, and send the hydrolysate to a concentrator for concentration. Get the concentrate to shrink. The concentrated liquid is injected into a spray dryer for spray drying to obtain solid fucoidan oligosaccharides....

Embodiment 2

[0025] A fucoidan oligosaccharide tea polyphenol anti-radiation composite preparation, the active ingredients of the composite preparation are fucoidan oligosaccharides and tea polyphenols, and the fucoidan oligosaccharides and tea polyphenols are mixed according to a weight ratio of 1:5.

[0026] The preparation method is as described in Example 1.

Embodiment 3

[0028] A fucoidan oligosaccharide tea polyphenol anti-radiation composite preparation, the active ingredients of the composite preparation are fucoidan oligosaccharides and tea polyphenols, and the fucoidan oligosaccharides and tea polyphenols are mixed according to a weight ratio of 1:6.

[0029] The preparation method is as described in Example 1.

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PUM

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Abstract

The invention relates to an alginate oligomers compound preparation and particularly relates to an alginate oligomers polyphenol anti-radiation composite preparation. The active ingredients of the compound preparation are alginate oligomers and tea polyphenol which are mixed in a weight ratio of (1:4) to (1:10). The alginate oligomers compound preparation provided by the invention has an anti-radiation effect, can be used for obviously prolonging the survival time of a mouse and enhancing the leucocyte injury defensiveness of the mouse, and meanwhile can be used for reducing micronucleus caused by 60Co-gamma ray radiation.

Description

Technical field [0001] The invention relates to a fucoidan oligosaccharide compound preparation, in particular to a fucoidan oligosaccharide tea polyphenol anti-radiation compound preparation. Background technique [0002] As nuclear energy is widely used in technology, production and daily life, it will inevitably cause radiation damage to people. Clinically, radiotherapy for cancer patients, radiation damage of occupationally exposed personnel, and space radiation received by personnel during space flight are highly valued. Under such circumstances, there is an urgent need for a natural, effective, non-toxic and side-effect health product. At present, the research of marine biological active substances at home and abroad has made great progress, especially the development of marine functional oligosaccharides has become an important topic and research hotspot in the field of international biotechnology. [0003] Alginate oligosaccharides, also known as alginate oligosaccharides...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/09A61K36/82A61K31/353A61K31/7016A61K31/702A61K31/715A61P17/16C08B37/00C07H3/06C07H3/04C07H1/00A23L33/125
Inventor 王静张斌管昶
Owner QINGDAO BZ OLIGO BIOTECH
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