Application of lentinan in preparing medicine, healthcare product and food in treating or preventing disease caused by enteric flora disturbance

A technology of intestinal flora and lentinan, applied in the field of lentinan, can solve the problems of poor stability and difficulty in ensuring the number of viable bacteria in live bacteria preparations, and achieve the effect of reducing the content

Inactive Publication Date: 2015-04-29
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing microecological regulators are live bacterial preparations such as Bifidobacterium and Lactobacillus, but live bacterial preparations have problems such as difficulty in ensuring the number of viable bacteria and poor stability

Method used

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  • Application of lentinan in preparing medicine, healthcare product and food in treating or preventing disease caused by enteric flora disturbance
  • Application of lentinan in preparing medicine, healthcare product and food in treating or preventing disease caused by enteric flora disturbance
  • Application of lentinan in preparing medicine, healthcare product and food in treating or preventing disease caused by enteric flora disturbance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The lentinan of the present invention is prepared by the following preparation method:

[0044] After pulverizing the shiitake mushrooms, add water according to the ratio of shiitake mushrooms: water = 1 g: 5 mL, and extract with heating and stirring at 75 ° C for 3 hours. The filter residue obtained by filtration is continuously extracted for 2 times according to the above-mentioned material-liquid ratio, temperature and time. After concentration under reduced pressure and centrifugation, a clear concentrate was obtained. According to the volume ratio of clear concentrate: 95% ethanol = 1:9, 9 times the volume of 95% ethanol was added to the clear concentrate. After mixing, let stand at 4°C overnight. Precipitate, collect the precipitate by centrifugation, and obtain lentinan after vacuum freeze-drying.

Embodiment 2

[0046] The lentinan of the present invention is prepared by the following preparation method:

[0047] After crushing the shiitake mushrooms, add water according to the ratio of shiitake mushrooms: water = 1 g: 8 mL, and heat and stir to extract at 70 ° C for 4 hours. The filter residue obtained by filtration is continuously extracted for 3 times according to the above-mentioned material-liquid ratio, temperature and time, and the 4 times of extracts are combined. Concentrated under reduced pressure and centrifuged to obtain a clear concentrate, add 8 times the volume of 95% ethanol to the clear concentrate according to the volume ratio of clear concentrate: 95% ethanol = 1:8, mix well and let stand at 4°C overnight Precipitate, collect the precipitate by centrifugation, and obtain lentinan after vacuum freeze-drying.

Embodiment 3

[0049] The lentinan of the present invention is prepared by the following preparation method:

[0050] After pulverizing the shiitake mushrooms, add water according to the ratio of shiitake mushrooms: water = 1 g: 10 mL, heat and stir at 80 ° C for extraction for 4 hours, and continue to extract the filter residue obtained by filtration for 2 times according to the above-mentioned material-liquid ratio, temperature and time, and combine the three extractions. Concentrated under reduced pressure and centrifuged to obtain a clear concentrate, add 6 times the volume of 95% ethanol to the clear concentrate according to the volume ratio of clear concentrate: 95% ethanol = 1:6, mix well and let stand at 20°C overnight Precipitate, collect the precipitate by centrifugation, and obtain lentinan after vacuum freeze-drying.

[0051] The lentinan prepared in the above examples can be used alone or with other Chinese herbal medicines or food additives and health care products or pharmaceu...

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Abstract

The invention provides application of lentinan in preparing medicines, healthcare products and food in treating or preventing diseases caused by enteric flora disturbance. The applicant of the invention adopts high-fat feed to induce a mouse obesity type-II diabetes model to observe the influence of polysaccharide in traditional Chinese medicines on lipid metabolism of mice through enteric florae, and by adopting the lentinan, enteric flora disturbance caused by diet can be adjusted, constitution of enteric florae can be remarkably improved, and the unbalance enteric florae in bodies can be recovered, so that the blood fat and the blood sugar indexes of obesity caused by enteric flora disturbance caused by diet can be adjusted, the content of triglyceride in blood plasma can be remarkably reduced, and the content of cholesterol, low density lipoprotein and free fatty acid can be reduced.

Description

technical field [0001] The invention relates to the use of lentinan, in particular to the use of lentinan in the preparation of medicines, health products and food for treating or preventing diseases caused by intestinal flora disturbance. Background technique [0002] People's eating habits are more inclined to high-fat, high-sugar, and high-calorie diets. With the improvement of material living standards, people's demand for high-fat diets is also increasing. A high-fat diet is also one of the important causes of obesity, diabetes and other diseases. In recent years, studies have found that some foods and drugs rich in polysaccharides have better effects in lowering blood sugar and lipids. Studies have shown that gut microbiota can control fat metabolism, trigger systemic chronic low-grade inflammation, and induce obesity and insulin resistance. Diet structure is an important factor in determining the composition of gut microbiota. Maintaining intestinal microecological...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A23L1/09A61P3/04A61P5/50A61P3/06A23L33/125
CPCA61K31/715A23V2002/00A23V2200/3262A23V2200/30A23V2250/51A23V2250/208
Inventor 王园园马方励胡明华梁明寇秀颖陈伟鸿从仁怀马忠华
Owner INFINITUS (CHINA) CO LTD
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