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Three-channel microsphere screening chip and use method

A three-channel, chip technology, applied to chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the problems of increased drying production costs, inconvenient screening, long filtration time, etc., to achieve convenient production Simple, Inexpensive, Professional Results

Active Publication Date: 2015-04-29
CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the large-scale use of oil-water O / W dual-phase technology to produce particles has been widely used in production, but the size screening of particle materials mostly uses the traditional method of filtration or dry particle sieving. It is not very convenient to screen the microspheres prepared by using liquid, especially for the micron particle size, it is easy to make the filtration invalid, or the filtration time is very long; if the microspheres are dried and then sieved, the above problems also exist. Increased drying production cost due to excessive particles

Method used

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  • Three-channel microsphere screening chip and use method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] refer to Figure 1 to Figure 5 In the shape structure, the chip specification 1 is 3 pieces, and the channel width between the fences is 2 μm; the chip specification 2 is 3 pieces, and the channel width between the fences is 5 μm.

[0024] The operation steps are as follows: In the first step, prepare the sample solution pretreated with a large-scale chip, and the diameter of the microsphere is about 5 μm.

[0025] In the second step, 2 specifications of chips, 6 chips in total, close all the screening outlets 9, inject deionized water from the injection port 2, and open all the screening outlets 9 after the deionized water flows out from the sample outlet 8. Negative pressure at the screening outlet 9, drainage of deionized water, after all the screening outlets 9 have deionized water flowing out, close all the screening outlets 9, sample inlet 2, and sample outlet 8, and wait for use.

[0026] In the third step, first use the second chip with the largest specificatio...

Embodiment 2

[0029] refer to Figure 1 to Figure 5 In the shape structure, the size of the 3-chip chip is five, and the channel width between the fences is 20 μm; the size of the 2-chip chip is eleven, and the channel width between the fences is 50 μm.

[0030] The size of the 2-chip chip is 21, and the channel width between the fences is 100 μm.

[0031] According to the operation method of Example 1, from large to small, finally collect the screening samples collected from the screening outlet 9 of the 11-chip screening outlet of 3 specifications, and obtain microspheres with a particle size between ?50 μm and ?100 μm.

[0032] Finally, collect the screening samples collected by the screening outlet 9 of the screening outlet 9 of three specifications of five chips, and obtain microspheres with a particle size between -20 μm and -50 μm.

Embodiment 3

[0034] refer to Figure 1 to Figure 5 In the shape structure, the 4-piece chip size 6, the channel width between the fences is 25 μm; the 3-piece chip size 7, the channel width between the fences is 30 μm.

[0035]3 chip size 8, the channel width between the barriers is 35μm.

[0036] According to the operation method of Example 1, from large to small, finally collect the screening samples collected from the screening outlet 9 of the screening outlet 9 of 3-size seven chips, and obtain microspheres with a particle size of ?30 μm ~ ?35 μm.

[0037] Finally, collect the screening samples collected by the screening outlet 9 of the screening outlet 9 of 3 pieces of six chips, and obtain microspheres with a particle size of ?25 μm ~ ?30 μm.

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Abstract

The invention provides a three-channel microsphere screening chip which is characterized in that a screening channel which is 30mm in length and 2.0mm in width is formed in a rectangular chip body, one collecting channel is formed in each side of each screening channel; the screening channels are communicated with the collecting channels through screening fence holes; three fences are arranged inside the screening fence holes; and anti-blocking columns are arranged outside the screening fence holes. The invention further provides an operation method of the chip body. The three-channel microsphere screening chip is relatively high in specialty, can be directly connected and used with capillary tubes of a production line, convenient and simple to manufacture and low in cost as multiple chips of different specifications can be combined randomly, and the screening efficiency is improved.

Description

technical field [0001] The invention relates to a new type of microsphere screening chip. In terms of use, it is a three-channel microsphere screening chip used in materials science and medicine and its use method. Background technique [0002] At present, the large-scale use of oil-water O / W dual-phase technology to produce particles has been widely used in production, but the size screening of particle materials mostly uses the traditional method of filtration or dry particle sieving. It is not very convenient to screen the microspheres prepared by using liquid, especially for the micron particle size, it is easy to make the filtration invalid, or the filtration time is very long; if the microspheres are dried and then sieved, the above problems also exist. The production cost of drying due to exceeding the standard particles has been increased. Microfluidic chips are a new technology developed in recent years. For micron droplet particles, they have the characteristics o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 廖晓玲徐文峰许杰刘雪
Owner CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY
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