A kind of method that polypropylene glycol and polyethylene glycol improve the hydrophilicity and flexibility of polypeptide film
A technology of polypropylene glycol and polyethylene glycol, applied in the field of polymer film preparation, to achieve the effect of easy mastery and simple operation
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Embodiment 1
[0017] 1) Synthesis of Polypeptide-Polypropylene Glycol Block Copolymer
[0018] Add 16.1 g of poly(r-benzyl-L-glutamate) (molecular weight: 80,000) and 7 g of carboxy-terminated polypropylene glycol monobutyl ether (molecular weight: 3,000) into the dry reactor, and add 300 ml of dimethyl base formamide, then add 0.048 g N, N’ -Dicyclohexylcarbodiimide, stirred and reacted at 20°C for 3 days under an inert atmosphere, terminated the reaction, and obtained the target product by filtration, dialysis and drying;
[0019] 2) Synthesis of Polyethylene Glycol-Polypropylene Glycol Block Copolymer
[0020] Add 3 g of amino-terminated polyethylene glycol monomethyl ether (molecular weight: 5,000) and 9 g of carboxyl-terminated polypropylene glycol monobutyl ether (molecular weight: 3,000) into the drying reactor, add 160 ml of dimethylformamide, and then Add 0.145 g N,N' -Dicyclohexylcarbodiimide, under an inert atmosphere, stirred and reacted at 25°C for 2 days, then terminated t...
Embodiment 2
[0025] 1) Synthesis of Polypeptide-Polypropylene Glycol Block Copolymer
[0026] Add 16.3 g of poly(r-ethyl-L-glutamate) (molecular weight: 85,000) and 7 g of carboxy-terminated polypropylene glycol monobutyl ether (molecular weight: 3,500) into the dry reactor, and add 305 ml of dimethyl Formamide, then add 0.031 g of N,N'-diisopropylcarbodiimide, under an inert atmosphere, stir and react at 25°C for 4 days, terminate the reaction, and obtain the target product by filtration, dialysis, and drying;
[0027] 2) Synthesis of Polyethylene Glycol-Polypropylene Glycol Block Copolymer
[0028] Add 3 g of amino-terminated polyethylene glycol monomethyl ether (molecular weight: 5,500) and 9 g of carboxy-terminated polypropylene glycol monobutyl ether (molecular weight: 3,500) into the dry reactor, add 155 ml of dimethylformamide, and then Add 0.08 g N,N' -Diisopropylcarbodiimide, under an inert atmosphere, stirred at 28°C for 3 days, then terminated the reaction, filtered, dialyzed,...
Embodiment 3
[0033] 1) Synthesis of Polypeptide-Polypropylene Glycol Block Copolymer
[0034] Add 16.5 g of poly(r-methyl-L-glutamate) (molecular weight: 90,000) and 7 g of carboxy-terminated polypropylene glycol monobutyl ether (molecular weight: 4,000) into the dry reactor, and add 310 ml of dimethyl Formamide, then add 0.046 g of 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under an inert atmosphere, stir and react at 30°C for 3 days, terminate the reaction, filter, dialyze, and dry, get the target
[0035] 2) Synthesis of Polyethylene Glycol-Polypropylene Glycol Block Copolymer
[0036] Add 3.1 g of amino-terminated polyethylene glycol monomethyl ether (molecular weight: 6,000) and 9.2 g of carboxyl-terminated polypropylene glycol monobutyl ether (molecular weight: 4,000) into the dry reactor, add 158 ml of dimethylformamide, and then Add 0.141 g of 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under an inert atmosphere, stir the reaction at 35°C for 2 days, then terminate the r...
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