Aerosol for treating bedsore and preparation method of aerosol
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An aerosol and decubitus technology, which is applied in the field of aerosol for the treatment of decubitus and its preparation, can solve the problems of insignificant curative effect, slow repair process, and short drug effect time, so as to promote wound healing and long drug effect time , good effect of obedience
Active Publication Date: 2015-05-06
GUANGDONG OCEAN UNIVERSITY
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However, because the antibacterial substance tea tree essential oil in the aerosol is a volatile component, the drug effect time is short, frequent administration is required, and compliance is poor; in addition, simple chitosan promotes the wound repair process slowly, and the curative effect is not very significant
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Embodiment 1
[0025] At room temperature, take two 29 g of purified water (58 g in total) to dissolve 1.5 g of antimicrobial peptide and 0.5 g of carboxymethyl chitosan respectively to make a solution; add 1.0 g of vitamin B to the two solutions successively 2 (total 2.0 g) and 1.5 g sodium chloride (total 3.0 g), stir to dissolve; mix the above two solutions evenly to make a liquid medicine, sterilize the filling, seal, inject 35 g of dimethyl ether, and press the aerosol cap Instant product.
Embodiment 2
[0027] At room temperature, take two 35 g of purified water (70 g in total) to dissolve 1.8 g of antimicrobial peptide and 1.2 g of carboxymethyl chitosan respectively to make a solution; add 2.5 g of vitamin B to the two solutions successively 2 (total 5.0 g) and 1.0 g potassium chloride (total 2.0 g), stir and dissolve; mix the above two solutions evenly to make a liquid medicine, sterilize filling, seal, inject 20 g of dimethyl ether, and press the aerosol cap Instant product.
Embodiment 3
[0029] At room temperature, take two 33 g of purified water (66 g in total) to dissolve 0.5 g of antimicrobial peptide and 1.5 g of low molecular weight (3 kDa) chitosan respectively to make a solution; add 2.0 g of vitamin B to the two solutions successively 2 (total 4.0 g) and 1.0 g potassium chloride (total 2.0 g), stir to dissolve; mix the above two solutions evenly to make a liquid medicine, sterilize the filling, seal, inject 26 g of dimethyl ether, press the aerosol cap Instant product.
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Abstract
The invention relates to an aerosol for treating bedsore and a preparation method of the aerosol, and belongs to the technical field of a medical aerosol. The aerosol consists of the following components: antibacterial peptide, water-soluble chitosan, a synergist, a stabilizer, a propellant and the balance of purified water. The preparation method comprises the following steps: respectively preparing an antibacterial peptide solution and a chitosan solution, sequentially adding equivalent synergist and stabilizer to the two solutions, and then uniformly mixing the two solutions to obtain a medicine liquid, filling and sealing the medicine liquid, injecting the propellant and pressing an aerosol cover so as to obtain a finished product. Through a synergistic effect generated from the combination of the antibacterial peptide and the water-soluble chitosan, the aerosol disclosed by the invention is not only strong in antibacterial and anti-inflammatory properties, but also capable of accelerating and promoting the healing of a wound surface and quite excellent in effect of clinically treating bedsore; by virtue of the sprayed chitosan solution, a film can be rapidly formed on the surface of skin so as to effectively protect the wound surface and reduce inflection risk; and the film is degradable and absorbable, and is safe, clean and convenient; and the aerosol is stable in active ingredient, long in drug action time, free from frequent administration and good in compliance.
Description
technical field [0001] The invention relates to an aerosol, in particular to an aerosol for treating bedsores and a preparation method thereof, belonging to the technical field of medical aerosols. Background technique [0002] Bed sores, also known as pressure sores, pressure ulcers, etc., are due to long-term pressure on local tissues, resulting in continuous ischemia, hypoxia, and malnutrition, resulting in tissue ulceration and necrosis. Critically ill, long-term bedridden, unconscious, incontinence, limb paralysis, nutritional disorders, metabolic disorders and other diseases, it often occurs in bone prominences without muscle wrap or thin muscle layer, lack of adipose tissue protection and often under pressure . Bed sores not only bring pain to patients, but also affect the recovery of the primary disease, and even lead to sepsis, amputation or death. According to relevant literature, about 60,000 people die of bed sore complications every year. [0003] Chitosan is ...
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