Aerosol for treating bedsore and preparation method of aerosol

Abstract

The invention relates to an aerosol for treating bedsore and a preparation method of the aerosol, and belongs to the technical field of a medical aerosol. The aerosol consists of the following components: antibacterial peptide, water-soluble chitosan, a synergist, a stabilizer, a propellant and the balance of purified water. The preparation method comprises the following steps: respectively preparing an antibacterial peptide solution and a chitosan solution, sequentially adding equivalent synergist and stabilizer to the two solutions, and then uniformly mixing the two solutions to obtain a medicine liquid, filling and sealing the medicine liquid, injecting the propellant and pressing an aerosol cover so as to obtain a finished product. Through a synergistic effect generated from the combination of the antibacterial peptide and the water-soluble chitosan, the aerosol disclosed by the invention is not only strong in antibacterial and anti-inflammatory properties, but also capable of accelerating and promoting the healing of a wound surface and quite excellent in effect of clinically treating bedsore; by virtue of the sprayed chitosan solution, a film can be rapidly formed on the surface of skin so as to effectively protect the wound surface and reduce inflection risk; and the film is degradable and absorbable, and is safe, clean and convenient; and the aerosol is stable in active ingredient, long in drug action time, free from frequent administration and good in compliance.

Description

technical field

[0001] The invention relates to an aerosol, in particular to an aerosol for treating bedsores and a preparation method thereof, belonging to the technical field of medical aerosols. Background technique

[0002] Bed sores, also known as pressure sores, pressure ulcers, etc., are due to long-term pressure on local tissues, resulting in continuous ischemia, hypoxia, and malnutrition, resulting in tissue ulceration and necrosis. Critically ill, long-term bedridden, unconscious, incontinence, limb paralysis, nutritional disorders, metabolic disorders and other diseases, it often occurs in bone prominences without muscle wrap or thin muscle layer, lack of adipose tissue protection and often under pressure . Bed sores not only bring pain to patients, but also affect the recovery of the primary disease, and even lead to sepsis, amputation or death. According to relevant literature, about 60,000 people die of bed sore complications every year.

[0003] Chitosan is ...