A preparation method of hydroxysafflower yellow a freeze-dried powder injection and its product
A technology of freeze-dried powder injection and hydroxyl safflower, which is applied in the field of medicine and can solve problems such as poor stability and affecting drug stability
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Embodiment 1
[0027] Embodiment 1, the preparation of hydroxysafflower yellow A freeze-dried powder injection
[0028] 1. Preparation of Hydroxysafflower Yellow A
[0029] 1.1 Grind dried safflower with a Chinese herbal medicine grinder, weigh 700g of dried safflower powder, add 7000ml of water to soak for 24h, then heat in a water bath at 50°C for 1h, ultrasonic at 50°C for 10 minutes, filter with 4 layers of gauze, and filter the total filtrate with suction. Obtain filtrate 1 and filter residue for use. The filter residue was heated again in a water bath at 50°C for 1 hour, ultrasonicated at 50°C for 10 minutes, filtered with 4 layers of gauze and suction filtered to obtain filtrate 2. Combine filtrate 1 and filtrate 2, filter, concentrate the filtrate to a relative density of 1.16-1.26, add ethanol to make the alcohol content reach 70% (v / v), refrigerate, let stand for 48 hours, filter, and recover ethanol from the filtrate, And concentrate to a relative density of 1.10-1.14, add ethan...
Embodiment 2
[0040] Example 2, Preparation of Hydroxysafflower Yellow A Freeze-dried Powder Injection
[0041] 1. Preparation of Hydroxysafflower Yellow A
[0042] 1.1 Grind dried safflower with a traditional Chinese medicinal material grinder, weigh 700g of dried safflower powder, add 7000ml of water to soak for 24h, heat in a water bath at 60°C for 1.5h, ultrasonic at 50°C for 5 minutes, filter with 4 layers of gauze, and filter the total filtrate with suction , to obtain filtrate 1 and filter residue for use. The filter residue was heated again in a water bath at 60°C for 1.5h, ultrasonicated at 50°C for 5 minutes, filtered through 4 layers of gauze and suction filtered to obtain filtrate 2. Combine filtrate 1 and filtrate 2, filter, concentrate the filtrate to a relative density of 1.16-1.26, add ethanol to make the alcohol content reach 70% (v / v), refrigerate, let stand for 72 hours, filter, and recover ethanol from the filtrate, and concentrated to a relative density of 1.10 to 1.1...
experiment example 1
[0052] Experimental Example 1: Investigation of the Process Flow and Stability Study of Safflower Injection
[0053] 1. Preparation process of 2010 Pharmacopoeia Safflower Injection
[0054] Take 500g of safflower, add water and decoct three times, the first time is 1 hour, the second time is 50 minutes, the third time is 30 minutes, the decoction is combined, filtered, the filtrate is concentrated to a relative density of 1.161-26, and ethanol is added to make the ethanol content reach 70%, refrigerate, stand still for 48 hours, filter, filtrate recover ethanol, and concentrate to a relative density of 1.10-1.14, add ethanol to make the alcohol content reach 80%, refrigerate, stand still for 48 hours, filter, filtrate Recover ethanol and concentrate to a relative density of 1.16-1.20, add 10 times the amount of water, refrigerate, let stand for 16-24 hours, filter, concentrate the filtrate to a relative density of 1.02-1.04, adjust the pH with 50% sodium hydroxide solution V...
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