Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of pharmaceutical composition for treating synovitis and osteoarthritis and preparation method thereof

A technology for osteoarthritis and composition, applied in the field of pharmaceutical composition and preparation thereof, can solve the problems of large side effects, easy occurrence of gastric ulcer and the like

Active Publication Date: 2018-11-27
YABAO PHARMA GRP CO LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few varieties of Chinese patent medicines that use synovitis as an indication. Western medicines mainly use non-steroidal anti-inflammatory drugs, which have definite curative effects, but have large side effects and are prone to adverse reactions such as gastric ulcers.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of pharmaceutical composition for treating synovitis and osteoarthritis and preparation method thereof
  • A kind of pharmaceutical composition for treating synovitis and osteoarthritis and preparation method thereof
  • A kind of pharmaceutical composition for treating synovitis and osteoarthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0244] Embodiment 1: Granules

[0245]

[0246] Get Radix Paeoniae Rubra and add 10 times the amount of 70% ethanol, reflux extraction 3 times, each time for 0.5 hours, filter, combine the filtrate, the temperature of decompression concentration is 60 ℃, concentrate to a thick paste with a relative density of 1.30~1.35, reduce Press dry and pulverize into fine powder; Add 10 times the amount of water to the remaining ten raw materials in the composition, decoct 3 times for 1 hour each time, filter, combine the filtrate, and concentrate under reduced pressure at 60°C, the filtrate Concentrate to a clear paste with a relative density of 1.10-1.15, add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, filter, recover ethanol from the filtrate, concentrate under reduced pressure at 60°C, and concentrate to a relative density of 1.30- The thick paste of 1.35 is dried, crushed into fine powder, mixed with the fine powder extracted from Radix Paeoniae Rubra...

Embodiment 2

[0247] Embodiment 2: tablet

[0248]

[0249] Get Radix Paeoniae Rubra and add 2 times the amount of 90% ethanol, reflux and extract 6 times, each time for 0.2 hours, filter, combine the filtrate, and concentrate under reduced pressure at a temperature of 60°C, and concentrate to a thick paste with a relative density of 1.30 to 1.35. Press dry and pulverize into fine powder; add 2 times the amount of water to the other ten raw materials in the composition, decoct 5 times for 3 hours each time, filter, combine the filtrate, and concentrate under reduced pressure at 60°C, the filtrate Concentrate to a clear paste with a relative density of 1.10-1.15, add ethanol to make the alcohol content reach 40%, let stand for 12 hours, filter, recover ethanol from the filtrate, concentrate under reduced pressure at 60°C, and concentrate to a relative density of 1.30- The thick paste of 1.35 is dried, crushed into fine powder, mixed with the fine powder extracted from Radix Paeoniae Rubra...

Embodiment 3

[0250] Embodiment 3: pill

[0251]

[0252] Take Radix Paeoniae Rubra and add 20 times the amount of 40% ethanol, reflux extraction once, each time for 4 hours, filter, combine the filtrate, and concentrate under reduced pressure at a temperature of 60°C, and concentrate to a thick paste with a relative density of 1.30-1.35. Press dry and crush into fine powder; add 20 times the amount of water to the other ten raw materials in the composition, decoct once for 0.2 hours each time, filter, combine the filtrates, concentrate under reduced pressure at 60°C, and decoct the filtrates Concentrate to a clear paste with a relative density of 1.10-1.15, add ethanol to make the alcohol content reach 90%, let stand for 48 hours, filter, recover ethanol from the filtrate, concentrate under reduced pressure at 60°C, and concentrate to a relative density of 1.30- The thick paste of 1.35 is dried, crushed into fine powder, mixed with the fine powder extracted from Radix Paeoniae Rubra, ad...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a pharmaceutical composition for arthromeningitis and osteoarthritis treatment. The pharmaceutical composition comprises mulberry twig, red peony root, forsythia, rhizoma Chuanxiong, radix achyranthis bidentatae, dioscorea spongiosa, angelica, astragalus, polyporus, alisma and pericarpium citri reticulatae and other eleven medicines, pharmacological experiment results show that, the pharmaceutical composition has good therapeutic effect on arthromeningitis and osteoarthritis compared with a control drug; and by the investigation and verification test of the extraction process of the pharmaceutical composition, an optimum extraction method can be determined.

Description

field of invention [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for treating synovitis and osteoarthritis and a preparation method thereof. Background technique [0002] Synovitis is a multiple disease, and its site of incidence is mainly in the knee joint. Because the knee joint synovium is extensive and located in the superficial parts of the limbs, there are more chances of injury and infection. Knee joint synovitis is mainly a group of syndromes caused by knee joint sprains and various intra-articular injuries. Osteoarthritis (Knee Jiont Osteoarthritis, referred to as KOA) is an senile frequently-occurring disease, which belongs to the category of "gubi" and "knee pain" in traditional Chinese medicine. Its main clinical manifestations are slowly developing arthralgia, stiffness, joint swelling with limitation of motion. At present, there are few varieties of Chinese patent m...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61K9/14A61P19/02A61P19/04
Inventor 杨晓宁禹玉洪任武贤
Owner YABAO PHARMA GRP CO LTD