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However, arylnaphthyllignans represented by the general formula (1) shown below have hitherto unknown effects on activation of transglutaminase, production of ceramide, promotion of involucrin expression, maintenance or improvement of skin. Barrier function and moisturizing function, prevention or improvement of rough skin, and hair curling, curly hair, and wavy hair are useful
Method used
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preparation example Construction
[0098] In the preparation of the extract of acanthus or hydrangea, it is possible to use the acanthus or hydra as it is or to dry and pulverize the acanthus or hydra. In addition, steam distillates or pressed products of acanthus or hydrangea can also be used, refined products obtained by refining these with essential oils, etc. can also be used, and commercially available products can also be used. Acanthus or Hydra, or its steam distillate or pressed product can be used alone, or in combination of two or more.
[0099] The extraction solvent used in the preparation of the extract of Acanthus or Hydrangea can be appropriately selected, and solvents commonly used in the extraction of plant components can be listed, such as water; alcohols such as methanol, ethanol, propanol, butanol; Polyols such as ethylene glycol, propylene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, and 2,3-butanediol; ketones such as acetone and methyl ethyl ketone ; Esters such as methyl acet...
preparation example 1-1
[0360] 800 mL of 50 volume % ethanol aqueous solution was added to 80 g of the whole plant of Juechi (manufactured by Shinwa Bussan Co., Ltd.), and extraction was carried out at room temperature for 7 days. Thereafter, after filtering to obtain a crude extract, it was concentrated to dryness to obtain 6.6 g of extracted solids. This extracted solid content was dissolved in a 50 volume% ethanol aqueous solution so that the evaporation residual content was 1.0% (w / v), and a 50 volume% ethanol extract of acanthus was prepared.
preparation example 1-2
[0362] 500 mL of a 95% by volume ethanol aqueous solution was added to 50 g of the whole plant of Juechi (manufactured by Shinwa Bussan Co., Ltd.), and extraction was carried out at room temperature for 7 days. Thereafter, after filtering to obtain a crude extract, it was concentrated to dryness to obtain 897 mg of extracted solids. This extracted solid content was dissolved in 95 vol% ethanol aqueous solution so that the evaporation residual content was 1.0% (w / v), and a 95 vol% ethanol extract of Acanthus was prepared.
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Abstract
A transglutaminase activator comprising at least one component selected from the group consisting of an extract of a plant Justicia procumbens, an extract of a plant Peristrophe japonica and a compound represented by general formula (1) as an active ingredient. [In general formula (1), R1 and R2 independently represent a hydrogen atom, a hydroxyl group or an alkoxy group having 1 to 4 carbon atoms; R3 represents a hydrogen atom or a group capable of binding to R2 to form a methylenedioxy group; R4 and R5 independently represent a hydrogen atom, or represent groups capable of binding to each other to form a methylenedioxy group; R6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms, an acyloxy group having 1 to 4 carbon atoms, or a specific sugar residue.]
Description
technical field [0001] The present invention relates to a transglutaminase activator, a ceramide production promoter, and an involucrin expression promoter. Background technique [0002] The stratum corneum of the epidermis serves as a barrier function to prevent transpiration of water in the body, stimulation from the outside, and invasion of foreign substances. The stratum corneum is composed of corneocytes and intercellular lipids, and the corneocytes are surrounded by a cell membrane-like structure called a cornified envelope. The cornified envelope contributes to the construction of a stable keratinocyte structure, and is an important structure for maintaining the barrier function of the skin. Keratinocytes located in the basal layer of the stratum corneum are keratinized, and involucrin (in this specification, also referred to as "IVL"), loricrin, etc., which are proteins required for keratinization, are synthesized, and then, by Activation of transglutaminase thereb...
Claims
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