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Composition for treating livestock diarrhea and preparation method thereof

A technology for livestock and poultry diarrhea and a composition is applied in the field of a composition for treating livestock and poultry diarrhea and the field of preparation thereof, which can solve the problems of reduced drug sensitivity, increased drug dosage, excessive drug residues, etc. A friendly, intestinal fluid-reducing effect

Active Publication Date: 2015-07-22
SICHUAN ANIMAL SCI ACAD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] During the use of drugs, bacteria develop drug resistance, which reduces their sensitivity to drugs, and the therapeutic effect of these drugs alone decreases, and some even have no therapeutic effect, and some may cause other diseases due to secondary infection
In order to achieve the purpose of treating diseases, farmers generally adopt the method of increasing the dosage of drugs or prolonging the use time, which leads to the problem of excessive drug residues

Method used

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  • Composition for treating livestock diarrhea and preparation method thereof
  • Composition for treating livestock diarrhea and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] in vitro susceptibility test

[0036] 1. Materials

[0037] 1.1 Tested strains Escherichia coli and Salmonella were isolated, identified and preserved from the Sichuan Academy of Animal Husbandry Sciences from dead livestock and poultry.

[0038] 1.2 Test drugs Standard products of trimethoprim lactate, norfloxacin lactate, acemequin, and atropine sulfate were purchased from China Veterinary Drug Control Institute.

[0039] 1.3 M-H medium was purchased from Hangzhou Microbiological Reagent Co., Ltd.

[0040] 2. Method

[0041] 2.1 Preparation of test drugs

[0042] 2.1.1 A Norfloxacin Lactate Injection: Take 80ml of water for injection, heat it to boiling, cool to 80°C, add 10g of Norfloxacin Lactate (calculated as Norfloxacin), stir evenly to fully dissolve it, and then add Prescription amount of sodium bisulfite 0.2g, disodium edetate 0.01g, stir to dissolve; add water for injection to make up to 100ml, filter through membrane, potting, sterilize at 100°C for 30 m...

Embodiment 2

[0060] A preparation method for an injection for treating livestock and poultry diarrhea, comprising the following steps:

[0061] 1) Take 3ml of dimethyl sulfoxide, heat it properly, add 1g of acemethaquine and stir to dissolve.

[0062] 2) Take 80ml of water for injection and heat to boiling, cool to 80°C, add 5g of norfloxacin lactate, 2.5g of trimethoprim lactate, 0.05g of atropine, 0.15g of sodium bisulfite, 0.008 g of disodium edetate g, stir to dissolve.

[0063] 3) Add the solution prepared in step 1) into the solution prepared in step 2), stir evenly, make up the volume with water for injection, filter the filter, pot the filtrate, sterilize at 121°C and 0.15MPa for 15-20 minutes, and the prepared The present invention relates to norfloxacin lactate injection for treating livestock and poultry diarrhea.

Embodiment 3

[0065] A preparation method for an injection for treating livestock and poultry diarrhea, comprising the following steps:

[0066] 1) Take 3.5ml of dimethyl sulfoxide, heat it properly, add 2g of acemethaquine and stir to dissolve.

[0067] 2) Take 80ml of water for injection, heat it to boiling, cool to 80°C, add 10g of norfloxacin lactate, 5g of trimethoprim lactate, 0.1g of atropine, 0.25g of sodium bisulfite, and 0.015g of disodium edetate , stir to dissolve.

[0068] 3) Add the solution prepared in step 1) into the solution prepared in step 2), stir evenly, make up the volume with water for injection, filter the filter, pot the filtrate, sterilize at 121°C and 0.15MPa for 15-20 minutes, and the prepared The present invention relates to norfloxacin lactate injection for treating livestock and poultry diarrhea.

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Abstract

The invention relates to the field of veterinary drugs and particularly relates to a composition for treating livestock diarrhea and a preparation method thereof. The composition for treating the livestock diarrhea mainly comprises norfloxacin lactate and mequindox. The composition for treating the livestock diarrhea is mainly prepared from the norfloxacin lactate and the mequindox; the cooperation of the norfloxacin lactate and the mequindox is reinforced and the norfloxacin lactate and the mequindox are combined for use with dual function and dual bacteria restraining and sterilizing effects, so that the bacteria tolerance ratio is reduced, the bacteria susceptibility is increased, the effect on the livestock diarrhea is rapid, the antibiotic property is strong, the infection and the secondary infection can be prevented, the purpose of treating both symptoms and root causes is reached, the medication times and dosages are reduced and the exceeding problem of the medical residue is well solved. The preparation method of the composition for treating livestock diarrhea is simple in process and easy to realize; and the components in the preparation are uniformly distributed and easy to use, and the treating effect is good.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a composition for treating livestock and poultry diarrhea and a preparation method thereof. Background technique [0002] At present, the drugs used to treat livestock and poultry diarrhea include norfloxacin lactate and acemequine. Norfloxacin Lactate belongs to the quinolone class of antibiotics. By acting on the bacterial DNA gyrase (gyrase A) subunit, it inhibits bacterial DNA replication and transcription to produce a bactericidal effect. It has a strong bactericidal effect on Gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli, Salmonella, Pasteurella, Klebsiella pneumoniae, Aeromonas hydrophilic, etc., and also has a certain effect on mycoplasma. Intramuscular injection of norfloxacin lactate is absorbed rapidly, and the peak plasma concentration is reached within 1 to 2 hours. [0003] Methaquine belongs to antibacterial drug, and achieves antibac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/505A61K31/498A61K9/08A61P31/04A61P1/12A61P1/06A61K31/496A61K31/46
Inventor 王斌李旭廷李金良
Owner SICHUAN ANIMAL SCI ACAD
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