Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and application of essential oil inclusion compound

A volatile oil inclusion compound and volatile oil technology, which is applied in the direction of non-active ingredients of polymer compounds, medical preparations containing active ingredients, drug combinations, etc., can solve the problem that the method, necessary process, process parameters, Verification and explanation, affecting drug stability and curative effect, volatile oil inclusion cannot be realized, etc., to achieve stable properties, improve curative effect, and improve stability

Active Publication Date: 2015-07-29
孙彩娟 +2
View PDF1 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] "Pharmacopoeia of the People's Republic of China" 2010 Edition, a Qizhi Weitong Granule Standard [Preparation Method], its volatile oil is directly sprayed into the granules after extraction, and it is easy to volatilize and lose, which will inevitably affect the stability and curative effect of the drug
[0005] Patent CN200510084 discloses a traditional Chinese medicine for treating qi stagnation and stomach pain and its preparation method, but its preparation method does not provide the method, necessary process, process parameters, verification and description of volatile oil inclusion, and the inclusion of volatile oil cannot be realized of

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of essential oil inclusion compound
  • Preparation method and application of essential oil inclusion compound
  • Preparation method and application of essential oil inclusion compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The screening of embodiment 1 volatile oil extraction process

[0042] 1.1 Experimental drugs

[0043] Citrus aurantium and Cyperus cyperi (scorched): The decoction pieces of Citrus aurantium and Cyperus cyperi were purchased from Huayuan Pharmacy, Pingshan District, Benxi City, and passed the inspection according to the requirements under the first section of medicinal materials in the 2010 edition of the Pharmacopoeia of the People's Republic of China.

[0044] Reference substances: naringin (batch number: 110722-201111), neohesperidin (batch number: 111857-201102), purchased from China National Institutes for Food and Drug Control.

[0045] 1.2 Experiment related measurement methods

[0046] (1) Detection method of the percentage content of volatile oil

[0047] Adopt volatile oil extractor, measure according to " People's Republic of China Pharmacopoeia " 2010 edition appendix XD volatile oil determination method (method A), directly read volatile oil amount, calc...

Embodiment 2

[0129] The screening of embodiment 2 volatile oil inclusion process

[0130] 2.1. Experimental drugs

[0131] 2.1.1 Raw materials: Fructus aurantii and Rhizoma Cyperi (burnt) decoction pieces were purchased from the Huayuan Pharmacy in Pingshan District, Benxi City, and the Quality Research Office of the Institute of Chinese Materia Medica, Liaoning University of Traditional Chinese Medicine, in accordance with the 2010 edition of the Pharmacopoeia of the People's Republic of China under the item of a medicinal material The content of the requirements is to conduct quality inspection on Fructus Aurantii Fructus and Cyperus Cyperi (burnt) decoction pieces, and the inspection is qualified.

[0132] 2.1.2 Reference substances: All were purchased from China National Institutes for Food and Drug Control. Naringin batch number: 110722-201111; Neohesperidin batch number: 111857-201102.

[0133] 2.1.3 β-cyclodextrin: purchased from Mengzhou Huaxing Biochemical Co., Ltd., batch num...

Embodiment 3

[0199] Example 3 Verification of volatile oil inclusion process

[0200] 3.1 Verification of the utilization rate of volatile oil

[0201] Carry out process verification according to the volatile oil inclusion process determined by screening: Take 400mL of purified water and 80g of β-cyclodextrin, heat at 40°C to disperse evenly, add to the colloid mill, add 10mL of volatile oil in the grinding state, and grind for inclusion 90 minutes (colloid mill through cooling water, control the inclusion temperature below 40°C), after grinding, take out the mixture, refrigerate below 5°C for 24 hours, filter, discard the supernatant, take out the precipitate, and wash with an appropriate amount of absolute ethanol Wash, filter, discard the supernatant, take out the precipitate, and dry under reduced pressure below 50°C to obtain a dry inclusion complex, which is obtained by weighing. Repeated three times, the results are shown in Table 19.

[0202] The results of volatile oil utiliza...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
wavelengthaaaaaaaaaa
water absorptionaaaaaaaaaa
Login to View More

Abstract

The invention provides a volatile oil clathrate and a preparation method thereof. The volatile oil clathrate is prepared from a volatile oil extracted from fructus aurantii and rhizoma cyperi (roasted) in the mass ratio of 10: 10. The preparation method provides a volatile oil beta-cyclodextrin clathration method and related parameters thereof; due to the use of the method, the extraction ratio of the volatile oil is high; the method is used for the clathration of a volatile oil in Qi-stagnation stomachache treating granules and form-changing preparations thereof, and is capable of remarkably increasing the utilization rate of the volatile oil, preventing the volatile oil from volatilizing or deteriorating due to oxidization in the production and storage processes of drugs, and as a result, the stability of the drugs are improved and then the curative effects of the drugs are improved. The invention also provides a preparation method of the Qi-stagnation stomachache treating granule and form-changing preparations thereof.

Description

[0001] This application is a divisional application of a Chinese patent application with an application date of September 13, 2013, an application number of 201310416646.3, and an invention title of "a preparation method and application of a volatile oil clathrate". technical field [0002] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a volatile oil clathrate and its preparation method and application, more specifically, to a traditional Chinese medicine for treating qi stagnation and stomach pain prepared by using the method and its preparation method. Background technique [0003] Qizhi Weitong Granules are now included in the 2010 edition of "Pharmacopoeia of the People's Republic of China". The prescription is composed of Bupleurum, Radix Glycyrrhizae, Rhizoma Cyperi (burning), Corydalis Corydalis (burning), Radix Paeoniae Alba, and Citrus aurantium. Epigastric pain embolism. The drug was launched in the 1980s with rema...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61K47/40A61K9/16A61P1/14A61P1/00A61K36/752
Inventor 程岚赵琳李学涛袁子民吕佳刘玉强
Owner 孙彩娟
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com