Manganese and zinc metal complexes taking alocasia amazonica alkali as ligand as well as synthesis method and application of manganese and zinc metal complexes

A kind of technology of Guanyinlianamine base and synthesis method, which can be applied in the field of medicine and can solve the problems such as the blank of chemical synthesis and biological activity research.

Inactive Publication Date: 2015-08-19
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the chemical synthesis and biological activity research of transition metal complexes based on Guanyin Lianming is still blank

Method used

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  • Manganese and zinc metal complexes taking alocasia amazonica alkali as ligand as well as synthesis method and application of manganese and zinc metal complexes
  • Manganese and zinc metal complexes taking alocasia amazonica alkali as ligand as well as synthesis method and application of manganese and zinc metal complexes
  • Manganese and zinc metal complexes taking alocasia amazonica alkali as ligand as well as synthesis method and application of manganese and zinc metal complexes

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: Synthesize Mn with solution method Ⅱ -LY metal complexes

[0030] 0.15mmol Mn(ClO 4 ) 2 ·6H 2 O was dissolved in 5mL dimethyl sulfoxide, 0.1mmol LY was dissolved in 10mL methanol, after the two solutions were mixed, stirred and refluxed at 65°C for 24 hours, after the reaction was completed, lowered to 25°C to obtain a red solution; Concentrate to remove most of the solvent, and a large amount of precipitates precipitate out. After standing still, the precipitates are separated out, filtered after cooling, and the obtained precipitates are washed and dried to obtain a red crystal product (yield 83%).

[0031] Infrared spectroscopy, elemental analysis, electrospray mass spectrometry, and single crystal diffraction analysis were carried out on the obtained red crystals. The specific spectral characteristics are as follows:

[0032] (1) Infrared Spectrum

[0033] IR(KBr):(Ar-H)2942(m),(C=O)1609(m),(C=C)158814801466(s),(C-O)14121269(vs),(C=N)1096( s) cm ...

Embodiment 2

[0039] Embodiment 2: Synthesize Zn with solution method Ⅱ -LY complex

[0040] 0.15mmol Zn(ClO 4 ) 2 ·6H 2 O was dissolved in 5 mL of acetone, and 0.1 mmol LY was dissolved in 10 mL of acetone. After the two solutions were mixed, they were stirred and refluxed at 80 ° C for 18 hours. After the reaction was completed, the temperature was lowered to 25 ° C to obtain a red solution; Concentrate under reduced pressure to remove most of the solvent, stand still, precipitate, and separate red crystals, wash and dry to obtain a red crystal product (yield 90%).

[0041] Infrared spectroscopy, elemental analysis, electrospray mass spectrometry, and single crystal diffraction analysis were carried out on the obtained red crystals. The specific spectral characteristics are as follows:

[0042] (1) Infrared Spectrum

[0043] IR(KBr): (Ar-H)2944(m), (C=O)1608(m), (C=C)157814821467(s), (C-O)14121275(vs), (C=N)1045( s) cm -1

[0044] (2) elemental analysis, Anal.Calc.(for C 36 h 26...

Embodiment 3

[0048] Embodiment 3: solvothermal synthesis of Mn Ⅱ -LY metal complexes

[0049] In a thick-walled glass tube open at one end, add 0.1 mmol Mn(ClO 4 ) 2 ·6H 2 O and 0.1mmolLY, then add 2mL chloroform, after freezing with liquid nitrogen, seal the open end under vacuum conditions, mix well and react at 80°C for 72 hours, remove the solvent after the reaction, take the resulting red solid and wash it with ethanol , to remove unreacted substances and impurities, and vacuum-dried at 40°C for 8 hours to obtain a red solid, which was identified as the complex [C 56 h 41 Cl 8 MnN 3 o 17 ].

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Abstract

The invention discloses two new manganese and zinc metal complexes taking alocasia amazonica alkali as a ligand as well as a synthesis method and an application of the manganese and zinc metal complex. The manganese and zinc metal complexes are obtained by dissolving manganese perchlorate or zinc perchlorate and alocasia amazonica alkali in a polar solvent, and carrying out a complexing reaction; the manganese and zinc metal complexes specifically can be synthesised through a solution method or a solvothermal method. The applicant finds that the two new manganese and zinc metal complexes show up superior in-vitro anti-tumour activities compared with the alocasia amazonica alkali ligand by inspecting the proliferation inhibition activities of the two new manganese and zinc metal complexes on human tumour cell strains of NCl-H460, HepG-2, DLD-1, MGC80-3 and the like, and the toxicities of the two new manganese and zinc metal complexes on human normal hepatic cells HL-7702, wherein the zinc metal complex has a low toxicity on normal cells and a good potential medicinal value, and is expected to be used for preparing various anti-tumour medicines. The structural formulas of the complex are shown in formula (I) and formula (II) specified in the description.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to manganese and zinc metal complexes with Guanyin Lianmin as a ligand, a synthesis method and application thereof. Background technique [0002] Lysicamine is an isoquinoline alkaloid, which is extracted from the lotus leaves of the family Fangjiceae, Anemoneaceae and Nymphaeaceae. Modern pharmacological studies have proved that Guanyin Lianmingine has antibacterial, anti-inflammatory and anti-tumor effects. Judging from the current research situation on Avalokitesvara, it mainly includes two aspects: on the one hand, it is obtained from plants of different families and genera (such as Aristolochia northernis, Suanzaoren, golden thread hanging turtle stems and leaves, and Magnolia officinalis, etc.) Quantitative extraction and component analysis of it; on the other hand, it is the study of its pharmacological activity, especially the anti-tumor activity. It has been proved that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F3/06C07D221/18A61K31/555A61K31/473A61P35/00
CPCC07F3/06A61K31/473A61K31/555C07D221/18C07F13/005
Inventor 黄克斌陈振锋梁宏何小菊谢晓丽
Owner GUANGXI NORMAL UNIV
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