6H-indolo[2,3-b]quinoxaline derivative, and preparation method and application thereof

A 3-b, quinoxaline technology, applied in organic chemistry, drug combination, anti-tumor drugs, etc., can solve the problem of anti-tumor activity that has not been reported in the literature, and achieve good anti-tumor activity and good inhibitory activity in vitro
CN110540541AInactive Publication Date: 2019-12-06GUANGXI NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUANGXI NORMAL UNIV
Publication Date
2019-12-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a 6H-indolo[2,3-b]quinoxaline derivative, and a preparation method and application thereof. The general formula is as shown in the specification. The preparation method comprises a step of preparing the 6H-indolo[2,3-b]quinoxaline derivative by taking o-phenylenediamine, indoldione, dihaloalkane and amine compounds as raw materials. The compounds provided by the invention show good antitumor activity.
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Description

technical field

[0001] The present invention relates to the technical fields of organic chemistry and medicinal chemistry, in particular to 6H-indolo[2,3-b]quinoxaline derivatives and their preparation methods and applications. These compounds exhibit good antitumor activity in vitro . Background technique

[0002] Malignant tumors are a serious threat to human health and are the second leading cause of death in the world. At present, the incidence of tumors in my country is increasing year by year, seriously endangering human health and a better life. The discovery of new anti-tumor lead compounds has very important research significance. 6H-indolo[2,3-b]quinoxaline derivatives are an important class of heterocyclic compounds. Currently, there are relatively few reports on their synthesis methods, and the research on their biological activities mainly focuses on antiviral activity. (Bioorganic & Medicinal Chemistry Letters 27(2017) 3915-3919; European Journal of Medicina...

Claims

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