Acetylpyrazine thiosemicarbazone metal chelating agent and preparation and application of metal complex of the acetylpyrazine thiosemicarbazone metal chelating agent

A technology of acetylpyrazine amino and diethyl semi-thiourea, which is applied in the field of medicine, can solve the problems that other metal-based compounds are useless and make significant progress, and achieve significant in vitro antitumor activity and good medicinal use. The effect of value, principle science
CN111138372AInactive Publication Date: 2020-05-12PINGDINGSHAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PINGDINGSHAN UNIVERSITY
Publication Date
2020-05-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an acetylpyrazine thiosemicarbazone metal chelating agent as well as a preparation method and application of a metal complex of the acetylpyrazine thiosemicarbazone metal chelating agent. The synthesis method of the acetylpyrazine thiosemicarbazone metal chelating agent comprises the following steps: with 2-acetylpyrazine and 4, 4-diethyl thiosemicarbazone as raw materialsand an alcohol substance and hydrochloric acid as solvents, carrying out a reaction to generate a yellow precipitate, collecting the precipitate, and washing the precipitate to obtain a ligand; takingthe obtained ligand and a metal salt, and carrying out a reaction with the alcohol substance and acetonitrile as solvents, carrying out standing treatment on the reactant, and separating out and collecting the crystal, so as to obtain the acetylpyrazine thiosemicarbazone metal chelating agent and the metal complex thereof. The acetylpyrazine thiosemicarbazone metal chelating agent and the metal complex thereof have remarkable anti-tumor activity and can be used for tumor treatment.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to the preparation and application of an acetylpyrazine thiosemicarbazone metal chelating agent and a metal complex thereof. Background technique

[0002] Although metal-based compounds are widely used in disease treatment, the lack of a clear distinction between therapeutic and toxic doses presents a major challenge. Barnett Rosenberg discovered cisplatin in 1960 and used it to treat cancer, which laid the foundation for the application of metal-based anticancer drugs. Although platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin are the main drugs used to treat cancer with metal-based compounds, the research and development of other metal-based compounds has not made significant progress. With the development of structural informatics, a series of other forms of metal-based compounds and non-classical platinum complexes that are different from known d...

Claims

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