Acetylpyrazine thiosemicarbazone metal chelating agent and preparation and application of metal complex of the acetylpyrazine thiosemicarbazone metal chelating agent
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- PINGDINGSHAN UNIVERSITY
- Publication Date
- 2020-05-12
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention belongs to the technical field of medicine, and in particular relates to the preparation and application of an acetylpyrazine thiosemicarbazone metal chelating agent and a metal complex thereof. Background technique
[0002] Although metal-based compounds are widely used in disease treatment, the lack of a clear distinction between therapeutic and toxic doses presents a major challenge. Barnett Rosenberg discovered cisplatin in 1960 and used it to treat cancer, which laid the foundation for the application of metal-based anticancer drugs. Although platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin are the main drugs used to treat cancer with metal-based compounds, the research and development of other metal-based compounds has not made significant progress. With the development of structural informatics, a series of other forms of metal-based compounds and non-classical platinum complexes that are different from known d...