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Materials and methods for protecting against neuromas

A neuroma, nerve technology, applied in the field of materials and methods for preventing neuroma, can solve the problem of non-adopting

Active Publication Date: 2015-08-19
AKSUNGEN AG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Existing methods for treating neuromas have not been successful and are generally not used

Method used

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  • Materials and methods for protecting against neuromas
  • Materials and methods for protecting against neuromas
  • Materials and methods for protecting against neuromas

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Embodiment Construction

[0022] The present invention provides devices and methods for alleviating the discomfort associated with neuromas. More specifically, the present invention relates to devices and methods for limiting the size of neuromas and physically surrounding neuromas to prevent the occurrence of stimuli that elicit neuropathic pain. In certain embodiments, the present invention relates to tissue engineered scaffolds that provide: a barrier to limit neuroma size, subdivide neuroma volume to reduce axonal cross-talk, and neuroma mechanical isolation.

[0023] The device of the present invention is designed as a protective connective tissue envelope surrounding the neuroma. Within the space created by the barrier, subdividing the injured nerve limits the amount of interaction between axons, thereby limiting signaling cascades within the neuroma that, when sensory nerve signal transduction occurs, can be interpreted as pain. By providing mechanical isolation, the present device limits the ...

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Abstract

The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application Serial No. 61 / 705,251, filed September 25, 2012, the entire contents of which are hereby incorporated by reference. Background technique [0003] Neuromas develop after peripheral nerve injury as part of the normal repair process. Neuromas form when nerve repair to a distal nerve or target organ fails and nerve fibers regenerate inappropriately and irregularly into surrounding scar tissue. Neuromas are composed of disorganized structures of axons, Schwann cells, endoneurial cells, and perineurial cells in a dense collagen matrix with surrounding fibroblasts (Mackinnon SE et al., 1985. Alteration of neuroma formation by manipulation of its microenvironment. Plast Reconstr Surg. 76:345-53). The upregulation of certain channels and receptors during neuroma formation may also cause abnormal sensitivity and spontaneous activity of damaged axons (Curtin C and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04
CPCA61N1/0558A61L31/04A61L2430/32A61N1/05
Inventor 柯特·戴斯特克里斯特尔·西蒙
Owner AKSUNGEN AG
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