Hemostasis patch and preparation method thereof

A hemostatic patch and blood coagulation factor technology, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of single function of the hemostatic patch and short hemostasis time, and achieve significant hemostasis, prevent bleeding, and protect the wound surface

Inactive Publication Date: 2015-08-26
FIRST HOSPITAL AFFILIATED TO GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the defect that the function of the hemostatic patch is too single in the prior art, to provide a self-adhesive bio-enclosed absorbable hemostatic patch that is

Method used

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  • Hemostasis patch and preparation method thereof
  • Hemostasis patch and preparation method thereof
  • Hemostasis patch and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0047] This example is used to illustrate the hemostatic patch of the present invention and its preparation method.

[0048] Take 4g chitosan, the degree of deacetylation is 80%, the viscosity is 2000mPa s, and the viscosity average molecular weight is 3.8×10 The chitosan-mussel mucin gel prepared in the range of ×106 has little difference in texture and hemostatic effect. Therefore, chitosan gel with a deacetylation degree of 80%, a viscosity of 2000mPa·s, and a viscosity-average molecular weight of 3.8×106 sugar as a representative, the remaining chitosan examples in the above range are omitted here), add 200mL of 2% acetic acid solution, stir at room temperature (20-25°C) until completely dissolved, let stand for defoaming, and filter to obtain clarified chitosan Sugar solution; add mussel mucin in chitosan solution, stir slowly until evenly so that the mass ratio of chitosan and mussel mucin is 500: 1; prepare mussel mucin glue with chitosan as matrix: Dry the chitosan-mu...

Embodiment 2

[0053] Except that the mass ratio of chitosan to mussel mucin is 250:1, all the other methods are the same as in Example 1.

Embodiment 3

[0055] Except that the mass ratio of chitosan to mussel mucin is 20:1, other methods are the same as in Example 1.

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Abstract

The invention relates to a hemostasis patch and a preparation method thereof. The hemostasis patch comprises an upper layer and a lower layer, wherein the upper layer is made of a hemostasis composite material, the lower layer is made of a high-viscosity biological material, the upper layer is smaller than the lower layer, and the upper layer is located in the middle of the lower layer. The high-viscosity biological material can be attached to biological connective tissue around blood vessels tightly so as to limit hemorrhage in a confined tissue cavity. The hemostasis patch has soft texture, high viscosity, low immunogenicity and high biocompatibility, is biodegradable, can stop bleeding in short time and has an excellent hemostasis effect.

Description

technical field [0001] The invention relates to the field of hemostatic products, in particular to a self-adhesive bio-enclosed absorbable hemostatic patch and a preparation method thereof. Background technique [0002] In the prior art, hemostatic plasters are usually used to care for wounds, hoping to achieve the effects of sealing, hemostasis, absorbing exudate, preventing wound infection, maintaining a moist environment of the wound, and promoting wound healing. With the gradual deepening of people's research on hemostasis theory and wound healing theory, the requirements for hemostatic stickers are getting higher and higher: ① hemostasis, pain relief, anti-inflammatory, ② non-toxic, harmless, non-irritating, ③ antibacterial and able to block bacteria , forming a good environment suitable for tissue growth, ④ having a suitable permeability of gas and water vapor. ⑤It can maintain the temperature and humidity of the contact surface of the wound, ⑥It can provide heat isol...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28A61L15/42A61L15/44
Inventor 赵明
Owner FIRST HOSPITAL AFFILIATED TO GENERAL HOSPITAL OF PLA
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