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Phenylephrine hydrochloride-chlorpheniramine maleate tablet and preparation method thereof

A technology of renin and chlorpheniramine acid, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, respiratory diseases, etc., can solve problems such as poor stability of preparations, achieve good stability, low production energy consumption, Simple preparation process

Active Publication Date: 2015-09-23
CHINA RESOURCES SANJIU MEDICAL & PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, the technical problem to be solved by this invention is to overcome the technical defects that phenylephrine hydrochloride easily produces impurities such as adducts and poor preparation stability in the existing compound preparation, thereby proposing a kind of phenylephrine hydrochloride / chlorine maleate Pheniramine tablet and preparation method thereof

Method used

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  • Phenylephrine hydrochloride-chlorpheniramine maleate tablet and preparation method thereof
  • Phenylephrine hydrochloride-chlorpheniramine maleate tablet and preparation method thereof
  • Phenylephrine hydrochloride-chlorpheniramine maleate tablet and preparation method thereof

Examples

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Embodiment 1

[0043] Embodiment 1: the present invention treats the renin Namin tablet of cold

[0044] The ingredients are composed of:

[0045]

Embodiment 2

[0046] Embodiment 2: the present invention treats the renin Namin tablet of cold

[0047] The ingredients are composed of:

[0048]

[0049]

Embodiment 3

[0050] Embodiment 3: the present invention treats the renin Namin tablet of cold

[0051] The ingredients are composed of:

[0052]

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PUM

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Abstract

The invention discloses a phenylephrine hydrochloride-chlorpheniramine maleate tablet and a preparation method thereof. The prescription of the phenylephrine hydrochloride-chlorpheniramine maleate tablet comprises phenylephrine hydrochloride, chlorpheniramine maleate, microcrystalline cellulose, dextrin, pregelatinized starch, sodium carboxymethyl starch, a silicon dioxide, a film coating premixing agent, lactic acid, propyl gallate and magnesium stearate. Compared with the prior art, the phenylephrine hydrochloride-chlorpheniramine maleate tablet prepared by the invention has the characteristics that the stability is good, the stability of key indicators of impurities and the like is obviously superior to that of a product which has been marketed abroad, and the dissolution rate of a medicine is equivalent to or slightly quicker than that of the product which has been marketed abroad.

Description

technical field [0001] The invention relates to a tablet for treating colds and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Influenza is clinical common disease and frequently-occurring disease. At present, the treatment of cold is still based on symptomatic treatment. Due to the diversity of cold symptoms, a single drug is often ineffective. However, compound preparations can target multiple cold symptoms at the same time and have the advantage of comprehensive control. They have gradually become mainstream products in the market. [0003] The components of common anti-cold medicines mainly include antipyretic and analgesic drugs, vasoconstrictor drugs, antihistamines, antitussive and expectorant drugs and antiviral drugs. Among them, the first choice of vasoconstrictor drugs is ephedrine drugs. However, ephedrine drugs belong to precursor chemicals, and the problem of using ephedrine compound prepara...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4402A61K9/30A61P31/16A61P11/02A61K31/137
Inventor 张艳斌刘志刚贺德龙余良钟马鹏岗孙亚洲
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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