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Compound bone cement precursor as well as preparation method and application of strontium borate bioglass/polymethyl methacrylate compound bone cement

A technology of polymethyl methacrylate and methyl methacrylate, which is applied in the field of biomedical repair materials, can solve the problems of easily damaged host tissue, unsatisfactory histocompatibility, and limited application scope.

Active Publication Date: 2015-09-23
深圳市中科海世御生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Polymethyl methacrylate (PMMA) bone cement, as the most widely used bone cement implant material in clinical practice, has been born for more than 50 years. It has certain biocompatibility and high mechanical properties, and can be used in The bone repair implant of the load-bearing part, but it cannot directly induce the growth of bone tissue, lacks biological activity and osseointegration performance, makes PMMA bone cement easy to damage the host tissue after implanted in the human body, and the histocompatibility is not ideal, thus limiting PMMA bone cement. The scope of application of bone cement in bone repair materials

Method used

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  • Compound bone cement precursor as well as preparation method and application of strontium borate bioglass/polymethyl methacrylate compound bone cement
  • Compound bone cement precursor as well as preparation method and application of strontium borate bioglass/polymethyl methacrylate compound bone cement
  • Compound bone cement precursor as well as preparation method and application of strontium borate bioglass/polymethyl methacrylate compound bone cement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] A preparation method of strontium borate bioglass / polymethyl methacrylate composite bone cement, comprising the steps of:

[0093] (1) Preparation of solid phase powder:

[0094] Preparation of strontium borate bioglass:

[0095] Weigh strontium borate bioglass 14SrO·2CaO·8MgO·54B according to molar ratio 2 o 3 ·2P 2 o 5 0SiO2 2 6Na 2 O·6K 2 After the raw materials of each component of O are mixed evenly, the original ingredients are placed in a platinum crucible and placed in a silicon-molybdenum furnace at 1100-1150 ° C, melted for 4 hours, and after taking it out, pour the obtained clear glass liquid into a preheated Get glass blocks on the steel plate. The obtained glass block is successively crushed, ball milled and sieved by crushing equipment, and the strontium borate bioglass with a particle diameter of 20-40 μm is selected for use;

[0096] Choose the polymethyl methacrylate (PMMA) powder that particle diameter is 20-40 μ m, the above-mentioned made st...

Embodiment 2

[0117] A preparation method of strontium borate bioglass / polymethyl methacrylate composite bone cement, comprising the steps of:

[0118] (1) Preparation of solid phase powder:

[0119] Preparation of strontium borate bioglass:

[0120] Weigh strontium borate bioglass 8SrO·22CaO·36B according to molar ratio 2 o 3 10P 2 o 5 18SiO2 2 · 8Na 2 After the raw materials of each component of O are mixed evenly, the original ingredients are placed in a platinum crucible and placed in a silicon-molybdenum furnace at 1100-1150 ° C, melted for 4 hours, and after taking it out, pour the obtained clear glass liquid into a preheated Get glass blocks on the steel plate. The obtained glass block is further crushed and classified by crushing equipment, and the strontium borate bioglass with a particle diameter of 20-40 μm is selected for use;

[0121] Select polymethyl methacrylate (PMMA) powder with a particle size of 40-60 μm, and mix the above-mentioned strontium borate bioglass with...

Embodiment 3

[0130] A preparation method of strontium borate bioglass / polymethyl methacrylate composite bone cement, comprising the steps of:

[0131] (1) Preparation of solid phase powder:

[0132] Preparation of strontium borate bioglass:

[0133] Weigh strontium borate bioglass 2SrO·14CaO·8MgO·18B according to molar ratio 2 o 3 ·4P 2 o 5 ·36SiO2 2 14K 2 After mixing the raw materials of each component of O.4CuO evenly, put the original ingredients in a platinum crucible and place it in a silicon-molybdenum furnace at 1100-1150°C, melt it for 4 hours, take it out, and pour the obtained clear glass liquid into the prepared Get the glass block on the hot steel plate. The obtained glass block is successively crushed, ball milled and sieved by crushing equipment, and the strontium borate bioglass with a particle diameter of 20-40 μm is selected for use;

[0134] Choose the polymethyl methacrylate (PMMA) powder that particle diameter is 60-80 μ m, the above-mentioned made strontium bo...

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Abstract

The invention discloses a polymethyl methacrylate (PMMA) compound bone cement precursor which comprises solid phase powder and solidification liquid, wherein the solid phase powder comprises strontium borate bioglass, polymethyl methacrylate powder and a polymerization initiator, the solidification liquid comprises methyl methacrylate and a polymerization activator, and the mass of the solid phase powder is 50 to 80 percent of the mass sum of the solid phase powder and the solidification liquid. The invention also provides a preparation method of polymethyl methacrylate compound bone cement, the compound bone cement combines the performance of the strontium borate bioglass and pure PMMA bone cement, has excellent biological activity, biological degradability, biological compatibility as well as mechanical strength matched with bones, so as to achieve a good effect on prompting bone reconstruction; the invention also provides an application of the strontium borate bioglass / polymethyl methacrylate compound bone cement.

Description

technical field [0001] The invention belongs to the field of biomedical repair materials, in particular to a preparation method and application of a composite bone cement precursor, strontium borate bioglass / polymethyl methacrylate composite bone cement. Background technique [0002] In recent years, the incidence of bone defects due to industrial accidents, traffic accidents, orthopedic diseases, etc. has been high. In addition, my country is currently moving towards an aging society, and the number of orthopedic degenerative diseases related to the elderly population continues to increase. The demand for materials is increasing. [0003] Bone cement is a bone repair material used in orthopedic surgery. Bone cement is usually composed of powder and monomer. It can be cured by mixing it in a certain proportion at room temperature, and it can be placed on the replacement joint or filling site After the reaction is over, the joint can be fixed or the bone defect can be repaire...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/10A61L27/18A61L27/58A61L27/54A61L27/50
Inventor 崔旭王践云陈丽娟杜丽娟
Owner 深圳市中科海世御生物科技有限公司
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