43 results about "Bone reconstructions" patented technology

The invention discloses a tooth intelligent segmentation and parameterized bionic reconstruction method fusing multi-modal data, and belongs to the field of artificial intelligence and computer-aided biomedical engineering. The method comprises a CBCT intelligent segmentation module, an intraoral scanning intelligent segmentation module, an internal tissue segmentation module, a point cloud generation registration module and a parameterized bionic reconstruction module. The point cloud generation registration module further comprises a point cloud generation sub-module and a point cloud registration sub-module; the parameterized bionic reconstruction module further comprises a dentin reconstruction sub-module, a cancellous bone reconstruction sub-module and a gingival reconstruction sub-module. The invention aims to realize tooth semantic segmentation, point cloud reconstruction and parameterized bionic modeling of an organization structure under cross-modal data fusion, and provides high-precision bionic internal structure information for teeth in combination with an artificial intelligence model and parameterized modeling.

Disclosed are platelet-derived extracellular vesicles (EVs), and composite materials comprising them, for use as bone replacement material and / or as bone rebuilding material. Also, methods of production, medical uses and kits are disclosed.

The invention provides a cartilage reconstruction method and device based on a diffusion model. The method comprises the following steps: acquiring a CT medical image; segmenting the CT medical image layer by layer to obtain a layer segmentation image; inputting the layer segmentation image into a pre-trained reconstruction model to obtain a layer reconstruction image; the reconstruction model is constructed based on a diffusion model; and generating a three-dimensional model with a cartilage layer based on the layer reconstruction image. According to the cartilage reconstruction method and device, noise adding and denoising are carried out on the CT medical image, so that the layer image with the cartilage is generated on the basis of the CT medical image, and cartilage reconstruction is achieved.

Disclosed are platelet-derived extracellular vesicles (EVs), and composite materials comprising them, for use as bone replacement material and / or as bone rebuilding material. Also, methods of production, medical uses and kits are disclosed.

The invention relates to a multi-view 3D skeleton real-time reconstruction method and a storage medium. The method comprises the following steps: acquiring skeleton data through an RGB camera array to obtain a video stream; the method comprises the following steps: preprocessing a video frame of a currently collected video stream, wherein the preprocessing comprises carrying out optical stream guide alignment on the current video frame; inputting the preprocessed current video frame into the spatial-temporal feature pyramid network for processing, and then outputting a multi-scale dynamic feature map; and inputting the multi-scale dynamic feature map into a physical constraint nerve radiation field for joint optimization to obtain a multi-view 3D skeleton model. Dynamic details are recovered by combining an optical flow guide alignment technology with a spatial-temporal characteristic pyramid network, and the problem of low-illumination motion blur is solved. 3D bone reconstruction is performed with low cost, high precision and real-time performance under the hardware configuration of a pure RGB camera or video camera.

The present invention relates to the technical field of medical devices, and particularly relates to a positioning structure and method for osteotomy and bone reconstruction. The positioning structure for osteotomy and bone reconstruction includes a positioning assembly; the positioning assembly includes an upper jaw positioning guide plate, a lower jaw osteotomy guide plate, and a reconstructed bone positioning guide plate; the upper jaw positioning guide plate has an upper jaw occlusal surface, an upper N-shaped splicing mechanism, a plurality of positioning holes, and a plurality of fixing holes; the lower jaw osteotomy guide plate has a lower N-shaped splicing mechanism, a connection area, a lower jaw lower edge indication area, and an osteotomy guiding surface; the reconstructed bone positioning guide plate includes an indication guide plate and a plurality of C-shaped connecting rods; after the upper jaw positioning guide plate is fixed, the insertion and cooperation of the two lower jaw guide plates can guide all the key steps of the operation, without repeated disassembly and adjustment, and maintain accurate positioning and intermaxillary distance to facilitate subsequent implant restoration; based on the upper jaw dentition, the lower jaw osteotomy position and the reconstructed bone position can be positioned, and it can be applied to patients with tooth loosening or lower jaw dentition loss caused by various reasons.

The application discloses application of mesenchymal stem cell spheroids in preparation of a preparation for treating osteoarthritis, and relates to the technical field of cell therapy and osteoarthritis treatment, and specifically comprises mesenchymal stem cell spheroids with an average diameter of 120-180 mu m and a solution containing 0.5%-10% human serum albumin. The cells are prepared into 120-180 mu m cell spheroids, and the solution containing specific concentration human serum albumin is used as a carrier, so that the cell survival rate is stabilized at more than 90%, and high-activity delivery is realized; the optimized size ensures smooth injection and long-term retention in the joint cavity, and overcomes the shortcoming that single cells are easily removed; after joint cavity injection, the preparation can synergistically promote bone reconstruction and cartilage repair, and produces clear curative effects such as bone mass increase of more than 30%, cartilage degeneration score reduction of more than 50%, and the like, which are quantifiable and verifiable, so that a stable, long-acting and curative drug preparation and application scheme are provided for osteoarthritis treatment.

The invention belongs to the technical field of biomedical materials, and particularly relates to an intelligent degradable three-dimensional porous scaffold with piezoelectric activity and a preparation method and application thereof. According to the method, the piezoelectric white calcium phosphate and the degradable metal material which are in a proper proportion are subjected to ultrasonic mixing, so that the piezoelectric white calcium phosphate is uniformly adsorbed on the surface of the degradable metal material in a physical adsorption mode, and then the composite powder obtained through mixing is subjected to 3D printing; the three-dimensional porous scaffold which is excellent in mechanical property, good in biological safety, sensitive in piezoelectric responsiveness and capable of adaptively regulating and controlling the degradation rate is prepared, a good supporting effect is provided for a critical bone defect part, meanwhile, the stress condition of the critical bone defect part is sensitively sensed, micro-current is generated in the three-dimensional porous scaffold through the stress effect, and the three-dimensional bone defect part is obtained. According to the invention, degradation of the degradable metal material and generation of new bones are promoted, and the degradation rate is adaptively adjusted according to the stress, so that the degradation rate is matched with the bone remodeling rate, and bone remodeling is effectively promoted.

The application relates to the technical field of implant denture repair of jaw bone reconstruction patients, and discloses a preparation method, equipment and medium of a soft tissue fixing and forming device, the method comprising the following steps: acquiring CT data and scanning data; fitting based on the CT data and the scanning data to determine the thickness of the surface soft tissue of the alveolar bone or the reconstructed jaw bone; then generating a virtual implant based on the implanted implant of the patient, obtaining the three-dimensional positions of the implants based on the virtual implant and the implant CT, so as to generate a virtual screw retention abutment according to the thickness of the surface soft tissue of the alveolar bone or the reconstructed jaw bone, and determine the gingival penetration position of the virtual screw retention abutment; and finally constructing the soft tissue fixing and forming device for jaw bone defect implantation based on the gingival penetration position, the three-dimensional positions of the implants and the scanning data. The soft tissue fixing and forming device for jaw bone defect implantation designed and prepared by the application has sufficient retention force, is not affected by lip and cheek movement, is comfortable to wear, is easy to clean and has a wider indication.

The application discloses a kind of craniofacial prosthesis systems based on digital simulation, specifically relates to digital simulation technical field, can preliminary predict and fine adjustment the three-dimensional image of bone defect area by mirror flip, functional area division and adjustment based on functional index, to more accurately reflect actual bone defect situation, provide strong support for subsequent repair scheme design;Through simulation simulation craniofacial movement and function, predict the functional recovery after bone defect repair, and output function simulation quality index, so that user can intuitively understand the repair effect, provide basis for treatment decision;Joint analysis surface smoothness index, function simulation quality index and simulation bone quality evaluation index, output bone reconstruction availability coefficient Ks;Judge the relationship between bone reconstruction availability coefficient and corresponding threshold Tza;Solve the problem that prior art cannot scientifically provide decision support for craniofacial prosthesis.

The invention relates to the technical field of medical image processing, in particular to an alveolar bone defect image restoration method based on global features, comprising the following steps: S1, acquiring three-dimensional CBCT image data of a patient to obtain a preprocessed image; s2, covering a part of image blocks of the preprocessed image by a global semantic restoration model to obtain random covering image blocks, and performing global semantic prediction on the random covering image blocks by a ViT encoder according to non-covering image blocks to generate a reconstructed image and a global attention feature map; s3, inputting the reconstructed image and the global attention feature map into a high-frequency detail restoration model to generate a restored image; s4, applying a three-dimensional continuity constraint to the repaired image; and S5, optimizing model parameters in combination with a multi-objective loss function, and updating the training model according to the model parameters. According to the method, full-automatic CBCT image repairing is achieved, preoperative accurate planning is assisted, the bone reconstruction target of an alveolar bone repairing operation is determined in an auxiliary mode, and the clinical curative effect of the alveolar bone defect repairing operation caused by tooth missing, tumor trauma and the like is improved.

The embodiment of the invention provides an integrated magnetically-driven bidirectional intramedullary nail, and belongs to the technical field of orthopedic implantation medical instruments. The bidirectional intramedullary nail comprises a sleeve and an integrated pipe section with a through hole, the telescopic unit is composed of a magnetic driving part, a speed reduction part, an extension part and a lining which are sequentially connected in series in the sleeve, and the telescopic unit comprises a first telescopic unit and a second telescopic unit which are symmetrically arranged in the sleeve along the middle plane in the axial direction; the limiting parts are arranged on the inner wall of the sleeve, and at least three levels of limiting parts are correspondingly arranged on the first telescopic unit and the second telescopic unit respectively and used for limiting the positions of the magnetic driving part, the speed reduction part and the extension part in the axial direction respectively; the part, located in the sleeve, of the lining limits the circumferential position of the extension part through a key groove structure, and the part, located outside the sleeve, of the lining and the end of the sleeve are fixedly arranged together to form a tail end limiting part. According to the bidirectional intramedullary nail, load-variable two-end bidirectional extension or contraction can be achieved so as to complete various bone reconstruction processes.

The invention discloses three-dimensional adjusting, fixing and supporting equipment used after sternum reconstruction, and relates to the technical field of sternum postoperative fixing and dynamic supporting instruments in the thoracic surgery department. The three-dimensional adjusting, fixing and supporting equipment used after sternum reconstruction comprises a front thoracic fitting supporting plate and a back thoracic fitting supporting plate, and the front thoracic fitting supporting plate and the back thoracic fitting supporting plate are fixedly connected through a middle flexible part, an upper movable part and a bottom movable part. According to the three-dimensional adjusting, fixing and supporting equipment used after the sternum reconstruction operation, the parts such as the prethoracic and thoracic attaching supporting plate, the bottom movable part, the bottom movable supporting connecting rod and the bottom supporting outer sleeve are arranged, the bottom movable part and the prethoracic and thoracic attaching supporting plate are matched with each other, and the bottom movable supporting connecting rod and the bottom supporting outer sleeve are matched with each other; the bottom movable supporting connecting rod can be movably adjusted through the interior of the bottom supporting outer sleeve and can be in linkage with the bottom of the prethoracic and thoracic attaching supporting plate.

The embodiment of the invention relates to the field of tooth orthodontics, and discloses a simulation method of a tooth orthodontic process and a determination method of an orthodontic scheme. The method comprises the following steps: S1, acquiring a dentition finite element mesh model, wherein the dentition finite element mesh model comprises finite element mesh models of teeth and periodontal ligament; s2, applying an orthodontic load to teeth in the dentition finite element model, and obtaining the initial movement amount of the teeth and the stress of the periodontal membrane; s3, obtaining a relation function between the alveolar bone unit reconstruction amount and the periodontal ligament stress, and calculating the alveolar bone reconstruction amount and reconstruction direction in unit time based on the relation function and the periodontal ligament stress obtained in the step S2; and S4, generating a simulated dentition model according to the initial movement amount, the alveolar bone reconstruction amount and the reconstruction direction. The actual orthodontic effect of the teeth can be obtained more comprehensively, so that the judgment on the orthodontic effect of tooth orthodontics is more accurate.

This application belongs to the field of biomedical materials technology, and more specifically, relates to a piezoelectrically active intelligent biodegradable three-dimensional porous scaffold, its preparation method, and its application. This application involves ultrasonically mixing a suitable ratio of piezoelectric white calcium phosphate stone and a biodegradable metal material, allowing the piezoelectric white calcium phosphate stone to be uniformly adsorbed onto the surface of the biodegradable metal material via physical adsorption. The resulting composite powder is then 3D printed to prepare a three-dimensional porous scaffold with excellent mechanical properties, good biosafety, sensitive piezoelectric response, and adaptively adjustable degradation rate. This scaffold provides good support for critical bone defects and sensitively detects the stress at the critical bone defect site. Through stress, a microcurrent is generated within the three-dimensional porous scaffold, promoting the degradation of the biodegradable metal material and the formation of new bone. The degradation rate is adaptively adjusted according to the stress magnitude to match the bone remodeling rate, effectively promoting bone remodeling.

The invention relates to the technical field of bone defect reconstruction, in particular to a 3D printing guide plate for autologous iliac bone extraction and bone defect reconstruction and a preparation method and application of the 3D printing guide plate for autologous iliac bone extraction and bone defect reconstruction. Tumor excision is simulated in a computer, and a bone defect area three-dimensional model is generated; according to the bone defect area model, the optimal ilium taking position, size, shape and bone taking scheme are determined through computer aided design; designing a bone taking guide plate and a fixing guide plate according to the bone taking scheme, wherein the guide plate is prepared through a 3D printing technology. According to the method, key steps (such as tumor resection simulation, bone taking scheme design and bone grafting fixation simulation) of bone defect reconstruction are all completed under the assistance of a computer, a standardized operation process is formed, and a standardized solution for bone defect reconstruction is constructed.

The invention relates to a customized device made of an inert and stiff ceramic for reconstruction of bone, bridging bone defects or reshaping of bone, more specifically the combination of material characteristics and design to protect the bone fracture or the volume where new bone is to be formed from motions and external forces that may disturb the bone formation and bone healing. This contributes to an optimal situation for natural bone healing that enhances the clinical outcome. The design of the implant member (1) is based on the initial bone structure (2) and the intended treatment where at least a part of the inner surface (9) of the implant member (1) directed towards the bone follow the irregularities of the initial bone structure (2) to mechanically support the area around the fixation screws (6) used to connect the implant member to the initial bone structure (2).

The invention belongs to the field of biomedical metal, and particularly relates to a preparation method and device of a porous ZnO / Zn bone reconstruction scaffold through adhesive jet 3D printing, and the preparation method comprises the following steps: S1, designing a porous network structure with the required porosity of 50-90% and the rod diameter of 50-500 [mu] m through software; s2, taking the zinc-based metal powder as a raw material, and preparing a porous scaffold blank by using a binder spraying metal 3D printer; s3, placing the porous scaffold blank in a baking oven at the temperature of 150-250 DEG C, and curing for 1-4 hours; s4, transferring the porous scaffold blank into a muffle furnace with the temperature of 300-500 DEG C, and degreasing for 1-5 hours; s5, transferring the porous scaffold blank into a muffle furnace at the temperature of 550-1200 DEG C, and sintering for 1-5 hours; and S6, cooling to room temperature to obtain the adhesive jet 3D printing porous ZnO / Zn bone reconstruction scaffold. The adhesive jet 3D printing porous ZnO / Zn bone reconstruction scaffold prepared by the method has good corrosion stability, cytocompatibility, osteogenesis performance, tube forming performance and antibacterial performance.

The invention discloses a cranio-maxillofacial repair system based on digital simulation, particularly relates to the technical field of digital simulation, and can preliminarily predict and finely adjust a three-dimensional image of a bone defect area through mirror image overturning, functional area division and adjustment based on functional indexes, so that the actual bone defect condition is reflected more accurately. Powerful support is provided for the design of a subsequent repair scheme; by simulating the movement and function of a craniomaxillofacial surface, the function recovery condition after bone defect repair is predicted, and a function simulation quality index is output, so that a user can intuitively understand the repair effect, and a basis is provided for treatment decision making; performing conjoint analysis on the surface smoothness index, the functional simulation quality index and the simulation bone quality evaluation index, and outputting a bone reconstruction availability coefficient Ks; judging the relationship between the bone reconstruction availability coefficient and a corresponding threshold Tza; the problem that decision support cannot be scientifically provided for craniomaxillofacial repair in the prior art is solved.

The invention relates to the field of biological agents, in particular to application of a plasmid composition to preparation of a medicine for treating bone defect and / or bone remodeling abnormality diseases. The plasmid group composition is a DNA (deoxyribonucleic acid) plasmid composition containing SEQ ID NO: 1 or a DNA plasmid composition containing more than 90% of similarity with the sequence of SEQ ID NO: 1. The plasmid composition provided by the invention has the effect of promoting bone injury repair, can promote bone defect repair and reconstruction, maintains better bone density, and has better healing effect. Meanwhile, the plasmid injection is free of obvious local stimulation and high in safety.

Systems and methods for bone reconstruction. In some implementations the systems and methods may be used to remove and replace a bone portion with an implant, which may be an allograft, biomaterial, metal implant, or any other type of implant. The systems and methods may be used to make accurate cuts in bone to remove a diseased bone portion and then reproduce the cuts in a donor material to recreate the precise geometry of the removed portion. Additionally or alternatively, the system can check the accuracy of reconstruction when a segment of bone is replaced.

The application provides a diffusion type three-dimensional bone reconstruction method and system based on image distribution enhancement, and belongs to the technical field of medical image processing, and comprises the following steps: acquiring DRR image and X-ray image data and performing data preprocessing; asymmetric gray scale remapping and KAN network driven geometric deformation are respectively applied to the DRR image and the X-ray image, different disturbance coefficients are given to the geometrically deformed images by adopting an asymmetric disturbance strategy to obtain enhanced DRR images and X-ray images; the enhanced DRR images and X-ray images are subjected to double-domain multi-scale feature fusion to obtain conditional embedded features; and based on the conditional embedded features, an initial noise volume is denoised to a bone CT volume by adopting a conditional diffusion model, so that three-dimensional bone reconstruction is completed. The application realizes the enhancement of bone features and the suppression of soft tissue noise in three-dimensional reconstruction.

The utility model discloses a bone patch composite stent. A G-BCP (at) PLA bone patch composite stent is prepared through a combined method of 3D printing and freeze drying. The composite scaffold is composed of a 3D printed PLA (or PCL) double-layer hexagonal support frame and a porous G-BCP bioactive filler, and is loaded with an active factor BMP, magnesium ions or icariin. The composite scaffold has the mechanical strength (20-40 MPa) and flexibility equivalent to those of cancellous bones, highly interconnected pores (the porosity is 40-70%), good osteoconductivity, osteoinductivity and vascularization promotion and appropriate degradation rate. The bone patch stent is free of cytotoxicity and can be converted into a clinical product so as to meet personalized, accurate and efficient bone reconstruction requirements of patients with large-area bone defects.

The application belongs to the field of bone repair materials, and particularly relates to a bone repair material with a through-hole structure and a preparation method thereof. The application provides a preparation method of a through-hole bone repair material, and the preparation method comprises the following steps: 1) preparing a bone repair raw material slurry: uniformly mixing raw materials of the bone repair material with water to form a bone repair raw material slurry; 2) preparing a bone repair preform; and 3) sintering treatment. The through-hole composite bone repair / bone reconstruction material provided by the application has a loofah sponge reverse structure, contains magnesium hydrogen phosphate with good solubility and degradability, calcium hydrogen phosphate capable of slowly degrading, and calcium sulfate capable of rapidly degrading and absorbing, has osteogenic elements calcium and phosphorus and a magnesium element capable of promoting bone tissue formation, can gradually degrade from a side in contact with bone tissue, and can provide components in the whole process of repairing and reconstructing bone tissue from a wound surface, promote tissue repair and reconstruction, and the like.

The invention discloses a 3D printing composite magnesium and nano-silver antibacterial degradable alveolar bone repair material and a preparation method thereof.The bone repair material is prepared from, by mass, 45%-65% of biodegradable polymer, 5%-25% of biodegradable inorganic matter, 5%-20% of nano-silver and 2%-10% of magnesium powder, and the total amount of all the components is 100%; the biodegradable inorganic matter is powdery, and the particle size of the biodegradable inorganic matter is 100-400 meshes; and the particle size of the magnesium powder is 100-400 meshes. The biodegradable polymer / biodegradable inorganic matter / nano-silver / magnesium powder is compounded into the same bone repair material, the material ratio of the inorganic matter to the magnesium powder is remarkably reduced due to the addition of the nano-silver, and better physical and chemical properties, a better bone tissue regeneration guiding / inducing effect and a better antibacterial effect are generated; the material can be degraded and absorbed in vivo, has good biocompatibility, is beneficial to alveolar bone reconstruction, and can also improve inflammation.

The invention belongs to the field of effects of traditional Chinese medicines in treatment of osteoporosis. The pathological change of osteoporosis is mainly bone microstructure injury, and comprises cortical bone thinning and porosity increase, bone trabecular connectivity loss, quantity reduction and gap increase, and bone reconstruction imbalance is the main reason of bone microstructure injury of osteoporosis patients. Adjustment of unbalanced bone metabolism and improvement of bone microstructure are key points in treatment. According to the technical scheme, the traditional Chinese medicine composition is preferably prepared from the following components in parts by weight: 1500 to 2500 parts of radix astragali seu hedysari, 300 to 600 parts of fructus schisandrae chinensis, 800 to 1200 parts of fructus lycii, 800 to 1200 parts of radix trichosanthis, 800 to 1200 parts of rhizoma anemarrhenae, 800 to 1200 parts of radix puerariae, 800 to 1200 parts of bulbus allii macrostemi, 500 to 700 parts of rhizoma acori graminei, 800 to 1200 parts of radix angelicae sinensis and 800 to 1200 parts of radix salviae miltiorrhizae. The traditional Chinese medicine composition disclosed by the invention can also be prepared into different dosage forms of medicines such as tablets, capsules, granules, oral liquid or injection together with pharmaceutically acceptable auxiliary materials.

The application discloses a bionic multi-membrane combined membrane piece type contact lens corrector and a design and preparation method, wherein the design and preparation method of the bionic multi-membrane combined membrane piece type contact lens corrector comprises the following steps: manufacturing a digital model of an initial state of teeth of a patient; manufacturing a digital tooth arrangement model of a target position of the teeth of the patient; designing grouping of a combined step of tooth movement; 3D printing a resin tooth model; and manufacturing the bionic combined membrane piece contact lens corrector by using a hot pressing technology.The product prepared by the application is more accurate and more continuous in force applied to the teeth, is in line with the alveolar bone reconstruction rule during orthodontic tooth movement, is higher in tooth movement efficiency, and is more comfortable for the patient to feel, and has the advantages of improving the defects of the traditional membrane piece treatment, such as too large force of a tooth movement corrector, time of force application not in line with a time period of alveolar bone reconstruction, obvious tooth pain of the patient, and easy to cause gum atrophy.

The invention relates to the technical field of medical diagnosis, and particularly discloses an osteoporotic fracture risk assessment method and a prediction model for the elderly, and a Nomogram risk prediction model is constructed by detecting the Non-HDLc / ApoB ratio of an elderly osteoporotic patient and combining factors such as a bone reconstruction balance parameter (BL), a bone transition rate (MoT) and age. The invention reveals that the Non-HDLc / ApoB ratio has significant association with the OPF risk and has nonlinear association close to statistical significance, the safety interval is 3.819-4.522, and accurate screening and individualized intervention of the OPF risk are realized based on the ratio. Model verification shows that the consistency index (C-index) is 0.732, and good clinical applicability is achieved.

The utility model relates to the technical field of oral and maxillofacial surgical medical instruments, and particularly discloses a maxillary bone total resection bone reconstruction operation synchronous implantation navigation implantation structure which comprises an implantation support, a navigation positioning hole, a navigation positioning hole, a navigation positioning hole, a navigation positioning hole and a navigation positioning hole. The guiding stent is matched with the implanting stent, and a tissue supporting space is formed between the guiding stent and the implanting stent; and the positioning target nail is matched with the navigation positioning hole and is used for providing a positioning base point. According to the scheme, the neck position of the positioning target nail is selected on three-dimensional modeling to serve as a mark point, the position relation during navigation is established through a space registration algorithm, planting site deviation caused by fibula implant fixing deviation is reduced, and drill point reaming and stent implantation are guided in real time under high precision in the maxilla total resection bone reconstruction operation; the 3D printed PEEK material implantation stent is adopted to replace the cut maxillary bone and part of the cheekbone, and the guide stent is used for providing support for fixation of the fibula implant, so that not only is the stability of the reconstruction structure ensured, but also the surgical operation and the postoperative recovery strategy are optimized.

The application provides bone reconstruction regulating polypeptides and application. On the basis of the first experiment of the inventors, bone reconstruction regulating polypeptides are designed and newly synthesized by using solid-phase polypeptide synthesis method through sequence alignment, structure analysis, physicochemical property and function prediction. The polypeptides have the characteristics of short length, simple synthesis, low cost, low cytotoxicity, high biological stability, moderate half-life, good bone targeting, and strong bone resorption regulating ability. The differentiation and function of osteoclasts and osteoblasts can be controlled by adjusting the concentration of the synthesized bone reconstruction regulating polypeptides, the ordered regulation of bone resorption and bone formation is realized, and the polypeptides have a broad potential application prospect.