12 results about "Bone reconstructions" patented technology

The application discloses application of mesenchymal stem cell spheroids in preparation of a preparation for treating osteoarthritis, and relates to the technical field of cell therapy and osteoarthritis treatment, and specifically comprises mesenchymal stem cell spheroids with an average diameter of 120-180 mu m and a solution containing 0.5%-10% human serum albumin. The cells are prepared into 120-180 mu m cell spheroids, and the solution containing specific concentration human serum albumin is used as a carrier, so that the cell survival rate is stabilized at more than 90%, and high-activity delivery is realized; the optimized size ensures smooth injection and long-term retention in the joint cavity, and overcomes the shortcoming that single cells are easily removed; after joint cavity injection, the preparation can synergistically promote bone reconstruction and cartilage repair, and produces clear curative effects such as bone mass increase of more than 30%, cartilage degeneration score reduction of more than 50%, and the like, which are quantifiable and verifiable, so that a stable, long-acting and curative drug preparation and application scheme are provided for osteoarthritis treatment.

The embodiment of the invention provides an integrated magnetically-driven bidirectional intramedullary nail, and belongs to the technical field of orthopedic implantation medical instruments. The bidirectional intramedullary nail comprises a sleeve and an integrated pipe section with a through hole, the telescopic unit is composed of a magnetic driving part, a speed reduction part, an extension part and a lining which are sequentially connected in series in the sleeve, and the telescopic unit comprises a first telescopic unit and a second telescopic unit which are symmetrically arranged in the sleeve along the middle plane in the axial direction; the limiting parts are arranged on the inner wall of the sleeve, and at least three levels of limiting parts are correspondingly arranged on the first telescopic unit and the second telescopic unit respectively and used for limiting the positions of the magnetic driving part, the speed reduction part and the extension part in the axial direction respectively; the part, located in the sleeve, of the lining limits the circumferential position of the extension part through a key groove structure, and the part, located outside the sleeve, of the lining and the end of the sleeve are fixedly arranged together to form a tail end limiting part. According to the bidirectional intramedullary nail, load-variable two-end bidirectional extension or contraction can be achieved so as to complete various bone reconstruction processes.

The invention discloses three-dimensional adjusting, fixing and supporting equipment used after sternum reconstruction, and relates to the technical field of sternum postoperative fixing and dynamic supporting instruments in the thoracic surgery department. The three-dimensional adjusting, fixing and supporting equipment used after sternum reconstruction comprises a front thoracic fitting supporting plate and a back thoracic fitting supporting plate, and the front thoracic fitting supporting plate and the back thoracic fitting supporting plate are fixedly connected through a middle flexible part, an upper movable part and a bottom movable part. According to the three-dimensional adjusting, fixing and supporting equipment used after the sternum reconstruction operation, the parts such as the prethoracic and thoracic attaching supporting plate, the bottom movable part, the bottom movable supporting connecting rod and the bottom supporting outer sleeve are arranged, the bottom movable part and the prethoracic and thoracic attaching supporting plate are matched with each other, and the bottom movable supporting connecting rod and the bottom supporting outer sleeve are matched with each other; the bottom movable supporting connecting rod can be movably adjusted through the interior of the bottom supporting outer sleeve and can be in linkage with the bottom of the prethoracic and thoracic attaching supporting plate.

This application belongs to the field of biomedical materials technology, and more specifically, relates to a piezoelectrically active intelligent biodegradable three-dimensional porous scaffold, its preparation method, and its application. This application involves ultrasonically mixing a suitable ratio of piezoelectric white calcium phosphate stone and a biodegradable metal material, allowing the piezoelectric white calcium phosphate stone to be uniformly adsorbed onto the surface of the biodegradable metal material via physical adsorption. The resulting composite powder is then 3D printed to prepare a three-dimensional porous scaffold with excellent mechanical properties, good biosafety, sensitive piezoelectric response, and adaptively adjustable degradation rate. This scaffold provides good support for critical bone defects and sensitively detects the stress at the critical bone defect site. Through stress, a microcurrent is generated within the three-dimensional porous scaffold, promoting the degradation of the biodegradable metal material and the formation of new bone. The degradation rate is adaptively adjusted according to the stress magnitude to match the bone remodeling rate, effectively promoting bone remodeling.

The application belongs to the field of bone repair materials, and particularly relates to a bone repair material with a through-hole structure and a preparation method thereof. The application provides a preparation method of a through-hole bone repair material, and the preparation method comprises the following steps: 1) preparing a bone repair raw material slurry: uniformly mixing raw materials of the bone repair material with water to form a bone repair raw material slurry; 2) preparing a bone repair preform; and 3) sintering treatment. The through-hole composite bone repair / bone reconstruction material provided by the application has a loofah sponge reverse structure, contains magnesium hydrogen phosphate with good solubility and degradability, calcium hydrogen phosphate capable of slowly degrading, and calcium sulfate capable of rapidly degrading and absorbing, has osteogenic elements calcium and phosphorus and a magnesium element capable of promoting bone tissue formation, can gradually degrade from a side in contact with bone tissue, and can provide components in the whole process of repairing and reconstructing bone tissue from a wound surface, promote tissue repair and reconstruction, and the like.

The invention relates to the technical field of medical diagnosis, and particularly discloses an osteoporotic fracture risk assessment method and a prediction model for the elderly, and a Nomogram risk prediction model is constructed by detecting the Non-HDLc / ApoB ratio of an elderly osteoporotic patient and combining factors such as a bone reconstruction balance parameter (BL), a bone transition rate (MoT) and age. The invention reveals that the Non-HDLc / ApoB ratio has significant association with the OPF risk and has nonlinear association close to statistical significance, the safety interval is 3.819-4.522, and accurate screening and individualized intervention of the OPF risk are realized based on the ratio. Model verification shows that the consistency index (C-index) is 0.732, and good clinical applicability is achieved.

The application provides bone reconstruction regulating polypeptides and application. On the basis of the first experiment of the inventors, bone reconstruction regulating polypeptides are designed and newly synthesized by using solid-phase polypeptide synthesis method through sequence alignment, structure analysis, physicochemical property and function prediction. The polypeptides have the characteristics of short length, simple synthesis, low cost, low cytotoxicity, high biological stability, moderate half-life, good bone targeting, and strong bone resorption regulating ability. The differentiation and function of osteoclasts and osteoblasts can be controlled by adjusting the concentration of the synthesized bone reconstruction regulating polypeptides, the ordered regulation of bone resorption and bone formation is realized, and the polypeptides have a broad potential application prospect.

The invention discloses a customized and assembled semi-sacrum biological prosthesis and a manufacturing method, and relates to the technical field of medical instruments, the customized and assembled semi-sacrum biological prosthesis comprises a prosthesis main body and an ilium reconstruction member, and the prosthesis main body and the ilium reconstruction member are detachably connected; a first fusion face is arranged at the upper end of the prosthesis body and used for being attached to a lumbar vertebra lower end plate, a second fusion face is arranged on the side face of the prosthesis body and used for being attached to a sacrum midline osteotomy face, a first hook body is arranged at the top of the ilium reconstruction piece, and a second hook body is arranged at the bottom of the ilium reconstruction piece. A first hook body is arranged at the bottom of the ilium reconstruction part and used for being connected with the top of the iliac wing, a second hook body is arranged at the bottom of the iliac reconstruction part and used for being connected with the front portion of the lower edge of the iliac bone, and a third fusion face is arranged on the side face of the iliac reconstruction part and used for being attached to the iliac bone cutting face. The ilium osteotomy surface and the lumbar vertebra lower end plate are in good butt joint, and biomechanical conduction of the pelvis of the human body is met.

The application discloses an artificial intelligence driven jaw bone defect bionic reconstruction system and method. A three-dimensional segmentation model is used to segment the facial CBCT image of a healthy person to construct a jaw bone dentition database; the segmentation model is used to segment the healthy side and the diseased side of the jaw bone of a patient, and intelligent matching is performed in the database based on the segmented healthy side jaw bone data as a reference to obtain the most similar target jaw bone; then the opposite jaw bone of the target jaw bone is taken as a to-be-applied template, three-dimensional integration is performed with the diseased side defect of the patient to generate a basic virtual jaw bone support; then a planting scheme is generated according to the matched healthy dentition data to obtain a segmented virtual support; trabecular bone structure filling is performed in the segmented virtual support to output a bionic reconstruction customized body; finally, the overhanging structure of the trabecular bone is detected according to the complex topological structure of the trabecular bone, and corresponding printing support is generated. The above can improve the bionic adaptation degree of the reconstructed defect jaw bone, and support entity production such as 3D printing.

The invention relates to a biomaterial comprising 70 to 90%, preferably 80 to 85%, by weight, of a powder of at least one fish co-product selected from the group consisting of fish scales and fish bones, and 10 to 30%, preferably 15 to 20%, by weight, of chitosan; the shaping of this biomaterial into an implant, in particular by 3D printing using fused deposition modeling; and the use of the implant for bone regrowth, bone reconstruction, and / or the treatment of osteoporosis. Figure to be published with the abstract: Fig. 1

The embodiment of the application provides a one-piece magnetic driving bidirectional intramedullary nail, and belongs to the technical field of orthopedic implant medical instruments. The bidirectional intramedullary nail comprises a sleeve, a one-piece pipe section with a through hole; a telescopic unit composed of a magnetic driving part, a speed reduction part, an extension part and a bushing which are sequentially connected in the sleeve, and the telescopic unit comprises a first telescopic unit and a second telescopic unit which are symmetrically arranged in the sleeve along the axial direction of the middle plane; a limiting part arranged on the inner wall of the sleeve, at least three limiting parts are arranged on the first telescopic unit and the second telescopic unit respectively, and the limiting parts are used for limiting the positions of the magnetic driving part, the speed reduction part and the extension part in the axial direction; the part of the bushing in the sleeve limits the position of the extension part in the circumferential direction through a key groove structure, and the part of the bushing outside the sleeve is fixedly arranged together with the end part of the sleeve to form a terminal limiting part. The bidirectional intramedullary nail can realize bidirectional extension or contraction of two ends under variable load to complete various bone reconstruction processes.