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Guided bone regeneration membrane and manufacturing method thereof

a bone regeneration and membrane technology, applied in the field of guided bone regeneration materials, can solve the problems of difficult to adopt this material difficult to handle these factors, and place a not-so-light burden on a patient, so as to improve the ability to adapt to an affected area, improve the ability to adapt to a large defect area, and improve the effect of cellular initial adhesion

Inactive Publication Date: 2012-12-13
NAGOYA INSTITUTE OF TECHNOLOGY +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The material demonstrates high cellular growth ability and improved bone reconstruction capabilities, offering a bioresorbable solution that excels in promoting bone regeneration without the need for secondary surgeries.

Problems solved by technology

This material, however, places a not-so light burden on a patient, because it is not bioresorbable and thereby needs a secondary operation for the removal of the membrane after the target bone defect area is repaired.
In addition, it is difficult to adopt this material to a large defect area, because the material is bioinert (non-bioresorbable).
However, it is difficult to handle these factors.

Method used

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  • Guided bone regeneration membrane and manufacturing method thereof
  • Guided bone regeneration membrane and manufacturing method thereof
  • Guided bone regeneration membrane and manufacturing method thereof

Examples

Experimental program
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Effect test

example 1

[0037]Manufacturing methods of guided bone regeneration membranes according to embodiments of the present invention will be illustrated with reference to several examples below. It should be noted, however, that these examples are included merely to aid in the understanding of the present invention and are not to be construed to limit the scope of the present invention.

[0038]Raw materials used in the examples are as follows:[0039]Silicon-releasing calcium carbonate (Si—CaCO3): Calcium carbonate of vaterite phase having a silicon content of 2.9 wt % prepared by using slaked lime (Microstar T; purity 96% or more; Yabashi Industries Co., Ltd., Japan), methanol (analytical grade reagent; purity 99.8% or more; Kishida Chemical Co., Ltd., Japan), γ-aminopropyltriethoxysilane (TSL 8331; purity 98% or more; GE Toshiba Silicones Co., Ltd., Japan), and carbon dioxide gas (high-purity liquefied carbon dioxide gas; purity 99.9%; Taiyo Kagaku Kogyo K.K.);[0040]Poly(lactic acid) (PLA): PURASORB P...

example 2

[0047]A spinning solution having a PLA content of 9.0 wt % was prepared by mixing 9 g of PLA and 91 g of CHCl3. Using this spinning solution, a PLA layer was prepared by electrospinning.

PLA Layer Preparation Conditions

[0048]In this example, the spinning solution feed rate is 0.05 ml / min, the applied voltage is 20 kV, and the distance between the nozzle and collector is 15 cm. The nozzle is fixed, so is the plate collector. The spinning time is 60 minutes.

[0049]Separately, PLA and Si—CaCO3 were kneaded in a heating kneader at 200° C. for 15 minutes to give a Si—CaCO3 / PLA composite containing 60 wt % of Si—CaCO3. A spinning solution having a Si—CaCO3 content of 13.0 wt % and a PLA content of 8.7 wt % was prepared by mixing 25 g of the Si—CaCO3 / PLA composite and 90 g of CHCl3. Using this spinning solution, a Si—CaCO3 / PLA layer was prepared by electrospinning.

Si—d CaCO3 / PLA Layer Preparation Conditions

[0050]In this example, the spinning solution feed rate is 0.05 ml / min, the applied vol...

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Abstract

A guided bone regeneration material is disclosed. The guided bone regeneration material includes biodegradable fibers produced by an electro spinning method. The biodegradable fibers produced by the method include a silicon-releasing calcium carbonate and a biodegradable polymer. The silicon-releasing calcium carbonate is a composite of siloxane and calcium carbonate of vaterite phase. The biodegradable fibers may be coated with apatite. When the guided bone regeneration material is immersed in a neutral aqueous solution, silicon species ions are eluted from the calcium carbonate. The guided bone regeneration material excels in bone reconstruction ability.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This is a continuation-in-part application of U.S. application Ser. No. 12 / 591,258 filed on Nov. 13, 2009, which claims the priority of Japanese Patent Application No. 2007-231621, filed on Sep. 6, 2007. The disclosures of these prior applications are incorporated by reference in their entireties.FIELD OF THE INVENTION[0002]The present invention relates to a guided bone regeneration material and a manufacturing method thereof. The guided bone regeneration material is used in a guided bone regeneration (GBR) technique which is a technique for repairing bone defects and is widely used in the field of oral surgery and maxillofacial surgery.RELATED ART OF THE INVENTION[0003]Guided bone regeneration membrane is a masking membrane that covers bone defect areas so as to prevent invasion of non-osteogenesis-contributing cells and tissues into the bone defect areas and to allow the bone to reconstruct by taking full advantage of the self-regenerat...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K33/10A61P19/08B29C47/00A61K9/70
CPCA61L31/06A61L31/128A61L31/148A61L2430/02A61K47/02A61K33/00C08L67/04A61P19/08
Inventor KASUGA, TOSHIHIROOTA, YOSHIOWAKITA, TAKASHI
Owner NAGOYA INSTITUTE OF TECHNOLOGY
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