Preparation method of drug for treating mild to moderate gastrorrhagia

Abstract

The present invention discloses a preparation method of a drug for treating mild to moderate gastrorrhagia so as to solve the treatment problem of gastrorrhagia of old people. The preparation method is characterized by comprising: (1) extracting volatile oil form rubusdelavayi franch coarse powder, eucommia ulmoides coarse powder, harlequin glorybower leaf and twig coarse powder, and finger citron coarse powder for spare, wherein the drug residue is used for spare; (2) soaking oxhide gelatin and polygonatum sibiricum for 12 h with 50 deg c hot water, adding water to decoct 2 times, and merging the decocting solutions for spare, wherein each decocting time is 1 h; (3) carrying out water extraction alcohol precipitation on ecdysanthera utilis, plum blossom, haiqian, Chinese buckeye seed, cynanchum mooreanum hemsl, poncirus trifollata(l.)raf and the drug residue in the step (1) to obtain a water extraction solution; and (4) mixing the decocting solution obtained in the step (2) and the water extraction solution obtained in the step (3), carrying out pressure reducing concentration and freeze-drying, crushing, spraying the volatile oil obtained in the step (1) into the crushed material, screening with a 100-mesh sieve, and sub-packaging to obtain the finished product. According to the present invention, clinical experiment results prove that the drug of the present invention has characteristics of good senile gastrorrhagia treating effect and high safety, and is worthy of clinical application and promotion.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a preparation method of a medicine for treating mild to moderate gastric bleeding. Background technique [0002] Upper gastrointestinal bleeding (UGIB), referred to as upper blood loss, is one of the common acute and severe diseases in gastroenterology. If it is not diagnosed quickly and treated in time, the fatality rate can reach more than 10%. The current emergency treatment methods are mostly: add 8 mg of norepinephrine to 100 mL of normal saline, put it in the refrigerator to cool down to 3°C-4°C, and take it 3-4 times a day orally or inject it through a gastric tube. This method is based on the contraction of surface capillaries, but the effect of promoting surface coagulation is not satisfactory. Therefore, it has also been reported in clinical reports that external hemostatic drugs such as Yunnan Baiyao are added to iced saline to enhance the hemostatic effect...

AI Technical Summary

Problems solved by technology

Difficulty in treatment lies in: ① Elderly patients are prone to relapse after treatment due to decline in body function, reduced heart pumping volume, and decreased blood volume in the whole body, resulting in decreased blood supply to the gastric mucosa and ulcers and various lesions; Patients may take a variety of drugs for a long time, and the medication is complicated, such as anticoagulant drugs, glucocorticoids, and non-steroidal anti-inflammatory drugs, which will increase the possibility of gastric mucosal damage due to increased gastric acid secretion, and increase the difficulty of hemostasis ; ③Because it is often accompanied by a variety of chronic diseases, especially with heart, brain, kidney and other important organ diseases, the application of hemostatic drugs including Yunnan Baiyao orally will change the fragile blood coagulation balance, and the hypercoagulable state will lead to the occurrence of cardiovascular and cerebrovascular accidents

[0004] Based on the above reasons, when upper gastrointestinal bleeding occurs in clinical elderly patients, especially gastric bleeding, the medication is limited, and it is easy to cause complications such as aspiration pneumonia and cardiovascular and cerebrovascular accidents, and the recurrence rate of bleeding is high.

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