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An injectable artificial bone compounded with microencapsulated artificial cells

An artificial cell and microencapsulation technology, applied in medical science, prosthesis, etc., can solve the problems of slow recovery and slow healing of bone wounds, and achieve the effects of alleviating pain, reducing trauma, and reducing the amount of internal fixation

Active Publication Date: 2017-12-15
天津顺永泰锦科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, this kind of bone graft material also has the disadvantages of slow healing and slow recovery of bone wounds.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] An injectable artificial bone compounded with microencapsulated artificial cells, comprising a solid phase component, a liquid phase component and a microencapsulated artificial cell component, the solid phase component comprising calcium carbonate, (-tricalcium phosphate and calcium hydrogen phosphate , the liquid phase component includes disodium hydrogen phosphate aqueous solution, the microencapsulated artificial cell component includes microbead capsules, and the microbead capsules are human bone marrow mesenchymal stem cells encapsulated by sodium alginate-polylysine-sodium alginate microcapsules Formed. After testing, the artificial bone of the present invention can be easily injected out by an injection needle with a length of 25cm and an inner diameter of 1.5mm, making it possible to adopt the minimally invasive method of percutaneous injection to fill the bone defect. pores, and the capsule wall of the microbead capsule has a certain compressive mechanical stre...

Embodiment 2

[0032] An injectable artificial bone compounded with microencapsulated artificial cells, comprising a solid phase component, a liquid phase component and a microencapsulated artificial cell component, the solid phase component including calcium carbonate, alpha-tricalcium phosphate and calcium hydrogen phosphate , calcium sulfate is also included in the solid phase component, and the mass percentages of calcium carbonate, α-tricalcium phosphate, calcium hydrogen phosphate and calcium sulfate in the solid phase component are respectively: calcium carbonate 10.4%, α-tricalcium phosphate 62.7% %, calcium dihydrogen phosphate 2.4% and calcium sulfate 20%;

[0033] The liquid phase components include disodium hydrogen phosphate aqueous solution and hydroxypropyl methylcellulose, and the mass concentrations of disodium hydrogen phosphate and hydroxypropyl methylcellulose in the liquid phase components are respectively: disodium hydrogen phosphate 28.4%, hydroxyl Propyl methylcellulo...

Embodiment 3

[0046] The above method of using the injectable artificial bone compounded with microencapsulated artificial cells, first mixes the liquid phase component and the microencapsulated artificial cell component, and then mixes them with the solid phase, quickly moves them into the syringe, and then passes through the corresponding injection needle It can be injected into the affected area, and the cement can be shaped arbitrarily during this period. After about 10 minutes, the artificial bone reaches the initial solidification, and at this time it cannot be shaped, otherwise it will break and affect the strength after curing. The final solidification is reached in about 15-20 minutes, and the artificial bone solidifies to a certain strength, and the wound can be sutured. The curing strength reaches its peak at 7 days, which is similar to the strength of cancellous bone. It can be applied to fractures and bone defects in metaphyseal cancellous bone, such as distal radius, proximal ...

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Abstract

The invention discloses an injectable artificial bone compounded with microencapsulated artificial cells, which is characterized in that it comprises a solid phase component, a liquid phase component and a microencapsulated artificial cell component, and the solid phase component includes calcium carbonate, α-tricalcium phosphate and calcium hydrogen phosphate, the liquid phase components include disodium hydrogen phosphate aqueous solution, the microencapsulated artificial cell components include microbead capsules, and the microbead capsules are made of sodium alginate polylysine Acine-sodium alginate microcapsules formed by encapsulating human bone marrow mesenchymal stem cells. Compared with the prior art, the present invention has the following advantages: it can be widely used in the fields of trauma orthopedics, spinal surgery, bone tumor, stomatology, orthopedic surgery, etc. It can fill bone defects with percutaneous injection instead of bone grafting, and minimally invasive treatment reduces trauma. Reduce the suffering of patients, accelerate the healing of damaged parts, reduce the amount of internal fixation, stabilize the fracture fragments early, enable patients to exercise early function, and avoid joint stiffness and displacement of fracture fragments.

Description

technical field [0001] The invention relates to the field of injectable artificial bone, in particular to an injectable artificial bone compounded with microencapsulated artificial cells. Background technique [0002] Tissue engineering technology can make inanimate materials composite with living cells to become living transplant replacement materials, which is the mainstream direction of life science development today. [0003] Currently, commonly used bone graft materials include autologous bone, allogeneic bone, hydroxyapatite, ceramics, and coral. Because these materials are solid, a long pruning process is required to adapt to the shape of the bone defect for filling, and a large incision exposure is required to fill the bone defect with the bone graft material, which makes minimally invasive treatment impossible. More traumatic. Calcium phosphate cement (CPC) family materials are a new type of bone graft material that has emerged in recent years. It is composed of s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/20A61L27/04A61L27/36A61L27/50A61L27/56
Inventor 苗军
Owner 天津顺永泰锦科技有限公司
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