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Methods for using autologous fibroblasts to alter skin identiy

A technology of fibroblasts and skin, applied in the direction of epidermal cells/skin cells, skin transplantation, animal cells, etc., can solve the problems of cell therapy optimization difficulties, obstacles to effective delivery of stem cells, and lack of optimal results

Inactive Publication Date: 2015-10-07
THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although allogeneic cells have been routinely used in wound therapy, optimal results have been hampered by a lack of knowledge about the effective delivery and implantation of stem cells into the skin
Moreover, optimization of cell therapy for chronic wound or bullous disease is difficult given the clinical variability and rarity of these conditions

Method used

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  • Methods for using autologous fibroblasts to alter skin identiy
  • Methods for using autologous fibroblasts to alter skin identiy
  • Methods for using autologous fibroblasts to alter skin identiy

Examples

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Embodiment

[0079] The following examples are presented to provide those of ordinary skill in the art with a complete disclosure and illustration of how to make and evaluate the compounds, compositions, articles, devices and / or methods described and claimed herein, and are intended purely for illustration, It is not intended to limit the scope of the invention as the inventors believe. Efforts have been made to ensure accuracy with respect to numbers (eg, amounts, temperature, etc.), but some errors and deviations may exist herein. Unless indicated otherwise, parts are parts by weight, temperature is in degrees Centigrade or is at ambient temperature, and pressure is at or near atmospheric. There are numerous variations and combinations of reaction conditions, such as component concentrations, desired solvents, solvent mixtures, temperatures, pressures, and other reaction ranges and conditions that can be used to optimize product purity and yield from the process. Rate. Only sound and r...

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Abstract

The present invention relates to the field of autologous fibroblasts. More specifically, the present invention provides methods and compositions comprising autologous fibroblasts and uses thereof to alter skin identity. In certain embodiments, volar fibroblasts can be expanded for the ability to induce volar skin at the stump site in amputees. In other embodiments, fibroblasts from haired scalp can be expanded to ameliorate alopecias.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 61 / 640,041, filed April 30, 2012, which is hereby incorporated by reference in its entirety. [0003] Statement of Government Interest [0004] This invention was made with US Government support under Grant No. 1K08AR05566601 Al. The US Government has certain rights in this invention. field of invention [0005] The present invention relates to the field of autologous fibroblasts. More specifically, the present invention provides methods and compositions comprising autologous fibroblasts and their use to alter the identity of skin. Background of the invention [0006] A major effort in regenerative medicine is to change tissue identity. In dermatology, applications for altering skin identity are broad and include reverting scars to their original tissue type. These efforts will likely involve cell therapy, as has been done, for example, in the i...

Claims

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Application Information

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IPC IPC(8): A61F2/10A61L27/38A61K35/33A61K35/36
CPCA61K35/33A61F2/10A61K35/36A61L27/362A61L27/60C12N5/0625A61L27/3804C12N5/0656
Inventor 路易斯·安德烈斯-加尔萨赛旺·康乔恩·H·迈耶勒
Owner THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE