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Selection and display of biomarker expressions

A technology of biomarkers and biological samples, applied in the direction of bioinformatics, input/output process of data processing, detailed information involving graphical user interface, etc.

Active Publication Date: 2015-10-14
莱卡微系统 CMS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Graphical user interface including main image panel and biomarker panel

Method used

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  • Selection and display of biomarker expressions
  • Selection and display of biomarker expressions
  • Selection and display of biomarker expressions

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Experimental program
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Embodiment Construction

[0047] Embodiments disclosed herein include methods for selectively visualizing biological samples and tissues and data corresponding to biological samples (e.g., expression levels of one or more biomarkers, one or more morphological features, one or more image analysis Methods, systems and apparatus for the results of methods, etc.). Exemplary embodiments enable a structured, yet fast, flexible and user-friendly display of biological samples, which facilitates biological research applications and allows pathologists to achieve objective and reproducible diagnoses and disease or condition models.

[0048] Certain exemplary embodiments provide a split screen display for viewing different portions of a selected field of view of a biological sample simultaneously. Depending on the resolution of the displayed field of view, the present invention contemplates that the field of view may show part or all of the image of the biological sample. It is contemplated that in most applicat...

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Abstract

Embodiments provide a user interface including an image panel for displaying a field of view corresponding to an image, or a portion of an image, of a biological specimen, and a biomarker panel for displaying thumbnail images for simultaneously viewing different aspects of a region within the field of view. Upon selection or update of the selected region of the field of view, the thumbnail images may be accordingly updated automatically to display the newly selected region. The image panel may include an interest region selection component for delineating a region within the field of view. The interest region selection component may be overlaid over a portion of the field of view displayed in the image panel, and may be used by a user to select or update the region within the field of view displayed in the biomarker panel. Images of interest may be saved to an electronic record.

Description

[0001] This application claims under 35 U.S. 119(e) U.S. Provisional Patent Applications Serial Nos. 61 / 889,820 filed October 11, 2013, 61 / 828,890 filed May 30, 2013, and Priority of 61 / 734,032 filed, the entire contents of which applications are hereby expressly incorporated by reference. Background technique [0002] Examination of tissue samples processed to reveal the expression of biomarkers is a known tool for biological investigation and therapeutic research. One such treatment involves the use of antibodies of interest or antibody surrogates, such as antibody fragments, which are specific for biomarkers, common proteins. Such antibodies or antibody surrogates may be directly or indirectly labeled with a moiety capable of generating a signal under appropriate conditions. For example, a fluorescent moiety can be attached to the antibody to interrogate the treated tissue for fluorescence. The signal obtained is generally indicative of both the presence and amount of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F15/18G16B25/00G16B45/00
CPCG06F3/048G01N35/00G01N2035/0091G06F19/20G06F19/26G16B45/00G16B25/00G06F3/04842G06F3/04847G06F3/0486G06T7/0012G06T2200/24G06T2207/10004G06T2207/10056G06T2207/30004
Inventor D.L.亨德森M.S.拉扎尔
Owner 莱卡微系统 CMS
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