Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

A technology selected from, chlorophenyl, applied in the field of disease treatment, can solve problems such as reducing cell proliferation

Active Publication Date: 2015-11-04
ABBVIE INC
View PDF24 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, inhibition of Bcl-2 protein may reduce cell proliferation, leading to improved effects related to the treatment and prevention of cancer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
  • Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
  • Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0229] 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[( 4-{[(2R)-1,4-dioxan-2-ylmethyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2,3 -b]pyridin-5-yloxy)benzamide

Embodiment 1A

[0231] Methyl 4,4-dimethyl-2-(trifluoromethylsulfonyloxy)cyclohex-1-enecarboxylate

[0232] To a hexane-washed suspension of NaH (17 g) in dichloromethane (700 mL) was added dropwise 5,5-dimethyl-2-methoxycarbonylcyclohexanone (38.5 g ). After stirring for 30 minutes, the mixture was cooled to -78 °C and trifluoromethanesulfonic anhydride (40 mL) was added. The reaction mixture was warmed to room temperature and stirred for 24 hours. The organic layer was washed with brine, dried (Na 2 SO 4 ), filtered, and concentrated to provide the title compound.

Embodiment 1B

[0234] Methyl 2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enecarboxylate

[0235] Example 1A (62.15 g), 4-chlorophenylboronic acid (32.24 g), CsF (64 g) and tetrakis(triphenylphosphine) in 2:1 dimethoxyethane / methanol (600 mL) Palladium(0) (2 g) was heated to 70 °C for 24 hours. The mixture was concentrated. Diethyl ether (4x 200 mL) was added and the mixture was filtered. The combined ether solutions were concentrated to provide the title compound.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.

Description

field of invention [0001] The invention relates to a compound for inhibiting the activity of Bcl-2 anti-apoptotic protein, a composition comprising the compound, and a method for treating diseases using the compound. Background of the invention [0002] The Bcl-2 family of proteins are key regulators of mitochondria-dependent apoptosis in nucleated cells and include anti-apoptotic (Bcl-x L , Bcl-2, Bcl-w, A1, Mcl-1) and pro-apoptotic (Bak, Bax, Bid, Bim, Bad, Bik, Bmf, Noxa, Puma) members. In general, expression of Bcl-2 protein is associated with a number of physiological functions, including inhibition of apoptosis in vivo, and in some cases leads to proliferation of cells affected by Bcl-2 inhibition. Therefore, inhibition of Bcl-2 protein may reduce cell proliferation, resulting in improved effects related to the treatment and prevention of cancer. [0003] Anti-apoptotic Bcl-2 proteins are associated with many diseases. Bcl-2 protein can be involved in bladder cancer...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/04A61P35/00A61K31/437
CPCC07D471/04A61K31/496A61K31/5377A61K45/06A61P35/00A61P37/00A61K31/437
Inventor 陶志福王锡禄M.D.温德特A.J.索尔斯A.S.朱德A.孔策尔G.萨利文
Owner ABBVIE INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com