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Application of a zinc-based montmorillonite and calcium-based montmorillonite aseptic hemostasis powder

A technology of calcium-based montmorillonite and zinc-based montmorillonite, which is applied in the field of medicine to achieve the effects of preventing wound infection, preventing reproduction, shortening bleeding time and plasma recalcification time

Active Publication Date: 2017-11-10
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent has the following defects: but this patent only has the function of hemostasis, without the function of convergence and healing of the wound surface
So far, the modification of montmorillonite into zinc-based montmorillonite and calcium-based montmorillonite has not been reported in the preparation of zinc-based montmorillonite and calcium-based montmorillonite aseptic hemostasis powder.

Method used

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  • Application of a zinc-based montmorillonite and calcium-based montmorillonite aseptic hemostasis powder
  • Application of a zinc-based montmorillonite and calcium-based montmorillonite aseptic hemostasis powder
  • Application of a zinc-based montmorillonite and calcium-based montmorillonite aseptic hemostasis powder

Examples

Experimental program
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Effect test

preparation example Construction

[0044] The quality standards of zinc-based montmorillonite and calcium-based montmorillonite aseptic hemostasis powder in the preparation method of the present invention are as follows, but not limited to the following standards for zinc-based montmorillonite and calcium-based montmorillonite aseptic hemostasis powder.

[0045] Zinc-based montmorillonite and calcium-based montmorillonite aseptic hemostasis powder

[0046] The zinc-based montmorillonite and calcium-based montmorillonite contained in this product should be 97.0% to 105.0% of the marked amount; the zinc ion is 3.5-5.5% of the marked amount of zinc-based montmorillonite and calcium-based montmorillonite, and the calcium ion is 3.5% to 5.5%. The marked amount of zinc-based montmorillonite and calcium-based montmorillonite is 3.5-5.5%.

[0047] 【Properties】This product is off-white powder.

[0048] [Identification] Take 0.5g of this product, put it in a stoppered bottle, add 50ml of purified water, add hydrochloric...

experiment example 1

[0057] Experimental Example 1: Sterilization experiment of zinc-based montmorillonite and calcium-based montmorillonite

[0058] In the application of the present invention, the active ingredients of the preparation, zinc-based montmorillonite and calcium-based montmorillonite, are layered minerals composed of montmorillonite-modified, extremely fine-grained hydrous aluminosilicates. The sterilization method of montmorillonite and calcium-based montmorillonite is to ensure that zinc-based montmorillonite and calcium-based montmorillonite aseptic hemostasis powder meet the quality standards, and ensure that zinc-based montmorillonite and calcium-based montmorillonite will stop bleeding. The powder medicine can be used safely and has a major innovation breakthrough.

[0059] 1. Zinc-based montmorillonite sterilization experiment

[0060] The comparison of different dry heat temperatures and dry heat times on the dry heat sterilization effect of zinc-based montmorillonite is sho...

experiment example 2

[0077] Experimental Example 2: Zinc-based montmorillonite and calcium-based montmorillonite rabbit skin irritation test

[0078] 1. Test material

[0079] (1) Medicine: take the zinc-based montmorillonite and calcium-based montmorillonite sterile hemostasis powder of Example 1 as the test sample for this experiment and set aside.

[0080] (2) Animals: healthy Japanese white-eared rabbits, body weight 2.0-2.4 kg, half male and half male, provided by the Experimental Animal Center of Shandong University.

[0081] (3) method

[0082] Six rabbits were randomly divided into intact skin group and damaged skin group according to sex and body weight, with 3 rabbits in each group. 24 hours before the administration, the two sides of the rabbit's back were depilated symmetrically, and the depilated area was 10% of the rabbit's body surface area (about 50 cm on each side). On the left is area A (blank control area), area B (70% ethanol control area), and on the right is area C (admini...

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Abstract

The invention relates to an application of zinc-based montmorillonite and calcium-based montmorillonite sterile styptic powder in preparation of medicines for healing skin wounds. The zinc-based montmorillonite and calcium-based montmorillonite sterile styptic powder is prepared from the following raw materials in parts by mass: 5-10 parts of zinc-based montmorillonite and 8-12 parts of calcium-based montmorillonite. According to the invention, zinc-based montmorillonite and calcium-based montmorillonite are used as effective ingredients of the medicament provided by the invention, and the effective ingredients are combined with pharmaceutical auxiliary materials to be prepared into the medicament through the processes of high-temperature dry heat sterilization, mixing, sterile sub-packaging and the like. Through skin external administration, the medicament can be used for quickly coagulating blood and arresting bleeding as well as preventing wound infection, has anti-bacterial and anti-inflammatory effects, and has converging and healing effects on the injured skin.

Description

technical field [0001] The invention relates to the application of Zhixue powder, in particular to the application of zinc-based montmorillonite and calcium-based montmorillonite sterile Zhixue powder, which belongs to the technical field of medicine. Background technique [0002] Blood is a liquid tissue consisting of plasma and red blood cells, white blood cells, particles, and platelets dispersed in the plasma. Plasma also contains water, acids, lipids, soluble electrolytes, and proteins. A special protein suspended in plasma is fibrinogen. In the case of bleeding, fibrinogen can react with water and thrombin to form insoluble fibrin and further polymerize to form a clot to stop bleeding. Under normal circumstances, when the animal body (including the human body) is injured and bleeding, the fibrinogen in the blood can exert the above-mentioned function and play the role of hemostasis. [0003] In many cases, bleeding from minor wounds can be suppressed by the blood's ow...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K33/30A61L15/18A61P7/04A61P17/02A61K33/06
Inventor 乔敏袁武杰
Owner SHANDONG SBOND PHARMA
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