Simethicone dry suspension and preparation method thereof

A technology of simethicone and dry suspension is applied in the directions of pharmaceutical formulations, active ingredients of silicon compounds, and medical preparations of non-active ingredients, etc. It can solve problems such as unseen products on the market, and achieve good taste, low cost and stable quality. Effect

Active Publication Date: 2018-02-06
SOUTHWEST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

With regard to simethicone dry suspension, there are no relevant research reports at home and abroad, and no related products are listed.

Method used

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  • Simethicone dry suspension and preparation method thereof
  • Simethicone dry suspension and preparation method thereof
  • Simethicone dry suspension and preparation method thereof

Examples

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preparation example Construction

[0048] The preparation method of Simethicone dry suspension, concrete steps are as follows:

[0049] a. Pre-dry all the solid excipients of the prescription at 40-60°C for 3 hours, and crush them through a 100-mesh sieve;

[0050] b. After grinding Tween 80 and Span 80 in a mortar, add the prescribed amount of simethicone and grind for 30 minutes, then add part of sucrose (40%-60%) to absorb and mix evenly, and then mix with The remaining sucrose, sodium carboxymethylcellulose, xanthan gum and cross-linked sodium carboxymethylcellulose are stirred and then sieved and mixed;

[0051] c. Add an appropriate volume of 75% ethanol solution to make a soft material, pass through a 20-mesh sieve to granulate, place it in an oven at 40-60°C for 2-3 hours, spray the banana essence solution, pass through a 20-mesh sieve for granulation, and obtain Lagata Silicone oil dry suspension.

[0052] Prescription 2

[0053] Simethicone dry suspension, its prescription is as follows:

[0054] ...

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Abstract

The invention discloses a simethicone dry suspension and a preparation method thereof. The simethicone dry suspension contains 4% simethicone by mass fraction and a pharmaceutically acceptable carrier. The simethicone dry suspension provided by the invention The preparation method has the advantages of simple operation and low cost, and is suitable for industrial production. The obtained product has the advantages of good taste, uniform distribution, good solubility, stable quality, etc. It is not only instant and easy to take, but also has a quick effect, and is suitable for the elderly, children and those with dysphagia. , increases the patient's compliance, and is more advantageous and more convenient than traditional liquid simethicone suspensions and emulsions in packaging, carrying, transportation, etc., for the treatment of abdominal distension caused by gas accumulation in the abdomen, abdominal Discomfort, indigestion, postoperative abdominal distension and other diseases have good application prospects.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to simethicone dry suspension, and also relates to a preparation method of simethicone dry suspension. Background technique [0002] Flatulence is the abdominal distension caused by excessive gas production in the gastrointestinal tract due to the etiology. It is very common in clinical practice, and often manifests as belching, abdominal distension, abdominal pain and loss of gas (farting). There are many reasons for flatulence, such as talking or gobbling while eating, inadvertently eating a lot of air is the main cause of flatulence. Followed by indigestion (due to excessive life pressure, emotional tension, irregular life, etc. can lead to insufficient secretion of digestive enzymes), various gastrointestinal diseases such as gastrointestinal inflammation, ulcers, tumors, etc. cause gastrointestinal dysfunction , obstruction of the passage, and reduced absorption of g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/695A61K47/26A61K47/38A61P1/00A61P1/14
Inventor 罗雷曾海春罗永煌高木珍张宁武煊王小红
Owner SOUTHWEST UNIV
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