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A kind of anti-inflammatory and antibacterial absorbable medical suture and preparation method thereof

A suture and solution technology, applied in the field of medical sutures, can solve the problems of bacterial infection of wounds and inflammatory reaction of skin tissue, etc., to increase antibacterial and anti-inflammatory properties, increase mechanical strength and cell affinity, and achieve good antibacterial and anti-inflammatory properties. sexual effect

Active Publication Date: 2018-01-05
安徽省康宁医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a foreign body, the suture exists in the incision tissue, and it is easy to cause inflammation in the skin tissue. The sutured wound is easily infected by bacteria in the surrounding environment of the body. Therefore, it is necessary to provide a suture with anti-inflammatory and antibacterial effects

Method used

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  • A kind of anti-inflammatory and antibacterial absorbable medical suture and preparation method thereof

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preparation example Construction

[0032] refer to figure 1 , the preparation method of a kind of anti-inflammatory and antibacterial absorbable medical suture that the present invention proposes, comprises the steps:

[0033] S1. Preparation of suture fiber: Mix carboxymethyl chitosan, polylactic acid, grass carp bone collagen, pigskin collagen, formaldehyde starch, and maltose, heat up to 70-90°C, and stir at a speed of 300-400r / min for 1 -2h, extrude with a twin-screw extruder, water-cooled, air-dried, and pelletized to obtain masterbatches; heat up to 140-160°C to melt the masterbatch, defoam, and obtain primary fibers through a spinneret; primary fibers at 40- Stretching in a water bath at 60°C to obtain suture fibers;

[0034] S2. Prepare a coating solution: add the coating to 40-50 parts of water, heat up to 50-70° C., and stir at a speed of 400-600 r / min for 4-6 hours to obtain a coating solution;

[0035] S3. Coating weaving: coating the suture fiber obtained in S1 with the coating solution obtained ...

Embodiment 1

[0038] An anti-inflammatory and antibacterial absorbable medical suture, its raw materials include by weight: 80 parts of carboxymethyl chitosan, 20 parts of polylactic acid, 10 parts of grass carp bone collagen, 12 parts of pig skin collagen, 4 parts of formaldehyde starch, 4 parts maltose, 1 part paint;

[0039] Among them, the preparation method of the coating is: adding chitosan to water, ultrasonically dispersing evenly, adding fumaric acid to mix evenly, adding perchloric acid dropwise, raising the temperature to 70°C, and stirring for 5 hours to obtain solution A; using NaHCO 3The solution adjusts the pH of solution A to 8, adds it dropwise into acetone, filters, washes twice with ethanol, filters, adds ethanol, Soxhlet extraction for 60 hours, and vacuum-dries to obtain modified chitosan, wherein, chitosan and water The weight to volume ratio (g / ml) of chitosan and fumaric acid is 1:60, the weight to volume ratio of chitosan to fumaric acid is 1.7:5.5, and the weight t...

Embodiment 2

[0045] An anti-inflammatory and antibacterial absorbable medical suture, its raw materials include by weight: 100 parts of carboxymethyl chitosan, 10 parts of polylactic acid, 15 parts of grass carp bone collagen, 8 parts of pig skin collagen, 6 parts of formaldehyde starch, 2 parts maltose, 5 parts paint;

[0046] Among them, the preparation method of the coating is: adding chitosan to water, ultrasonically dispersing evenly, adding fumaric acid and mixing, adding perchloric acid dropwise, raising the temperature to 50°C, and stirring for 7 hours to obtain solution A; using NaHCO 3 The solution was adjusted to pH=6 of solution A, added dropwise to acetone, filtered, washed 4 times with ethanol, filtered, added with ethanol, extracted by Soxhlet for 48 hours, and dried in vacuum to obtain modified chitosan, wherein chitosan and water The weight-to-volume ratio (g / ml) of chitosan and fumaric acid is 1:80, the weight-to-volume ratio (g / ml) of chitosan to perchloric acid is 1.7:5...

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Abstract

The invention discloses an anti-inflammatory and antibacterial absorbable medical suture, the raw materials of which include by weight: 80-100 parts of carboxymethyl chitosan, 10-20 parts of polylactic acid, 10-15 parts of grass carp collagen, and pigskin 8‑12 parts of collagen, 4‑6 parts of aldolized starch, 2‑4 parts of maltose, and 1‑5 parts of paint. The invention also discloses a preparation method of the above-mentioned anti-inflammatory and antibacterial absorbable medical suture, comprising the following steps: S1, preparing suture fiber; S2, preparing coating solution; S3, coating weaving. The invention has good antibacterial and anti-inflammation properties, good compatibility with biological tissues, easy adhesion and propagation of cells on the invention, good mechanical properties, simple operation, and is beneficial to industrialized production.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to an anti-inflammatory and antibacterial absorbable medical sutures and a preparation method thereof. Background technique [0002] Surgical suture refers to a special thread used for wound ligation, suture hemostasis and tissue suture in surgical operations. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. Absorbable sutures include natural fibers and synthetic polymer sutures. [0003] Polylactic acid (PLA) sutures are synthetic polymer sutures. The degradation rate of PLA fibers is slow and the mechanical properties are strong. However, PLA is hydrophobic, and cells cannot adhere and reproduce well on the fibers. Biodegradation The lactic acid produced can easily cause inflammation. [0004] Chitosan is a natural fiber suture with good biocompatibility, antibacterial ability, chemical inertness, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/12A61L17/08A61L17/10A61L17/14D01F8/18D01F8/14D01F1/10
Inventor 祁建兵
Owner 安徽省康宁医疗用品有限公司
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