Pharmaceutical composition for improving safety of compound gastrodin injection

A technology of gastrodin injection and composition, applied in the field of medicine, which can solve the problems of polysorbate 80 being prone to rancidity, accelerating the pH value of the liquid medicine, and the drop of the pH value of the solution, so as to achieve low dosage, improved safety, and good safety Effect

Inactive Publication Date: 2015-11-25
CHENGDU AIBIKE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the traditional Chinese medicine injection itself still has the problem that the pH value of the solution drops significantly during the sterilization and storage process, and polysorbate 80 (Tween 80) is prone to rancidity, which accelerates the drop of the pH value of the liquid medicine.

Method used

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  • Pharmaceutical composition for improving safety of compound gastrodin injection
  • Pharmaceutical composition for improving safety of compound gastrodin injection
  • Pharmaceutical composition for improving safety of compound gastrodin injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017]

[0018] Preparation method: decoct gastrodin and Chuanxiong with water twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate to relative density under reduced pressure. The density is about 1.15 (80°C), and the medicinal liquid is used for later use; the safflower is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, Add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduced pressure to a relative...

Embodiment 2

[0020]

[0021] Preparation method: decoct gastrodin and Chuanxiong with water twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate to relative density under reduced pressure. The density is about 1.15 (80°C), and the medicinal liquid is used for later use; the safflower is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, Add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduced pressure to a relative...

Embodiment 3

[0023]

[0024]

[0025]Preparation method: decoct gastrodin and Chuanxiong with water twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content 65%, stand overnight, filter, the filtrate recovers ethanol under reduced pressure and concentrates to a relative density of 1.30 (80°C), adds 3 times the amount of water, stirs thoroughly, refrigerates for 48 hours, filters, and concentrates the filtrate to relative density under reduced pressure. The density is about 1.15 (80°C), and the medicinal liquid is used for later use; the safflower is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, Add ethanol to make the ethanol content 65%, let it stand overnight, filter, concentrate the filtrate under reduced pressure to...

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Abstract

The invention discloses a pharmaceutical composition for improving the safety of a compound gastrodin injection. The pharmaceutical composition is mainly prepared from gastrodin extract, extract of chuanxiong rhizome, safflower extract and Solutol HS-15 for injections. According to the pharmaceutical composition for improving the safety of the compound gastrodin injection, cosolvent of polysorbate 80 which can cause potential safety hazards and affect product quality is replaced with cosolvent with better safety and a more obvious hydrotropy effect in the compound gastrodin injection, the safety of the Solutol HS-15 is higher than that of the polysorbate 80, the dosage of the Solutol HS-15 is lower than that of the polysorbate 80, the occurrence probability of untoward effects and risks of pharmaceuticals are reduced, and the safety of clinical medication is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for improving the safety of compound gastrodin injection. Background technique [0002] The standard of compound gastrodin injection is recorded in the drug standard issued by the Ministry of Health (preparation of traditional Chinese medicine). The raw materials are gastrodin, Chuanxiong, and safflower, which belong to traditional Chinese medicine injection. It has the effects of promoting blood circulation and promoting menstrual flow, dispelling blood stasis and relieving pain. It is clinically used to treat dysmenorrhea, amenorrhea, injury from tumbling, rheumatic arthralgia, etc. [0003] Compound gastrodin injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical applic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/286A61K9/08A61K47/34A61P29/00A61P15/00A61P17/02A61K31/7034
Inventor 何金蓉周洁
Owner CHENGDU AIBIKE BIOTECH
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