A kind of traditional Chinese medicine composition and its preparation method, application and preparation

Abstract

The invention discloses a traditional Chinese medicine composition and its preparation method, application and preparation. The weight ratio of raw materials is: Epimedium 3-75 parts, Centella asiatica 5-125 parts, Achyranthes bidentata 4-100 parts, Atractylodes macrocephala 4-100 parts 4-100 servings. Pharmacological studies show that the traditional Chinese medicine composition of the invention can significantly reduce the lesion degree of prostatic tissue in rats with prostatitis, significantly reduce the number of prostatic white blood cells, increase the density of prostatic lecithin bodies, and have a good therapeutic effect on prostatitis. The traditional Chinese medicine composition of the invention has easy-to-obtain raw materials, scientific preparation method, clear material basis, clear pharmacological action and mechanism, can treat both symptoms and root causes of prostatitis, and has broad application prospects.

Description

technical field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition and a preparation method, application and preparation thereof. Background technique

[0002] Prostatitis is an inflammatory reaction of the prostate caused by pathogenic infection or stimulation by non-infectious factors. Accompanied by inflammatory pus. The main clinical manifestations are frequent urination, poor urination, dribbling or white discharge after urination, perineal swelling, etc., and are often accompanied by pain symptoms in the lower abdomen, testicles, and penis. Prostatitis is mostly caused by bacterial or viral infection, and there are also cases of autoimmunity or other unknown reasons. Most of the infection occurs in the interstitium, and it is causal and interactive with the chronic congestion of the gland. Therefore, it is difficult to heal after a long time.

[0003] Prostatitis...

Examples

preparation example Construction

[0032] The preparation method of Chinese medicine composition of the present invention comprises the steps:

[0033] a. Achyranthes bidentata and Atractylodes macrocephala are crushed through a 10-mesh sieve, epimedium and centella asiatica are broken into short sections of 1-5 cm, put into containers, and the mass concentration of 4-6 times the dry weight of medicinal materials is added to 30-70% the ethanol, airtight and let it soak for 8-10 hours, transfer it to a percolator, extract 40-45 hours with ethanol with a mass concentration of 80-100 times the dry weight of medicinal materials and 30-70%, and collect the percolation extract ;

[0034] b. The above-mentioned percolation extract is filtered, and the filtrate is vacuum spray-dried at 30-50° C. to form a powder to obtain the traditional Chinese medicine composition of the present invention.

[0035] The application of the traditional Chinese medicine composition of the invention is the application in the preparation ...

Embodiment 1

[0038] The preparation of embodiment 1 Chinese medicine composition 1

[0039] 1. Origin and place of origin of medicinal materials

[0040] Epimedium: Epimedium, a plant of the Berberidaceae family Epimedium brevicornum Maxim The dry aerial part of . The place of production is Qujing, Yunnan, provided by Yunnan Yixintang Chinese Herbal Medicine Co., Ltd.

[0041] Centella asiatica: Centella asiatica Centella asiatica (L.) Dried whole herb of Urb. The place of origin is Wenshan, Yunnan, provided by Yunnan Yixintang Chinese Herbal Medicine Co., Ltd.

[0042] Achyranthes bidentata: Achyranthes sichuanensis of Amaranthaceae Cyathula officinalis Kuan dry roots. The place of origin is Sichuan, provided by Yunnan Yixintang Chinese Herbal Medicine Co., Ltd.

[0043] Atractylodes atractylodes: Atractylodes Atractylodes A tractylodes macrocephala Koidz The dry rhizome of . The place of origin is Baoshan, Yunnan, provided by Yunnan Yixintang Chinese Herbal Medicine Co., Lt...

Embodiment 2

[0049] The preparation of embodiment 2 Chinese medicine composition 2

[0050] 1. Origin and place of origin of medicinal materials

[0051] With embodiment 1.

[0052] 2. Prescription

[0053] Epimedium 75 parts, Centella asiatica 5 parts, Achyranthes bidentata 100 parts, Atractylodes macrocephala 4 parts.

[0054] 3. Preparation method:

[0055] Step 1): Weigh the medicinal materials according to the prescription amount. Achyranthes bidentata and Atractylodes macrocephala are crushed through a 10-mesh sieve. Epimedium and Centella asiatica are broken into short sections of 1-5 cm, put into a container, and add 6 times the dry weight of the medicinal materials Ethanol with a mass concentration of 70%, sealed and left to soak for 10 hours, transferred to a percolator, extracted with 70% ethanol with a mass concentration of 100 times the dry weight of medicinal materials for 45 hours, and collected the percolation extract;

[0056] Step 2): Filter the above-mentioned percol...

technical field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition and a preparation method, application and preparation thereof. Background technique

[0002] Prostatitis is an inflammatory reaction of the prostate caused by pathogenic infection or stimulation by non-infectious factors. Accompanied by inflammatory pus. The main clinical manifestations are frequent urination, poor urination, dribbling or white discharge after urination, perineal swelling, etc., and are often accompanied by pain symptoms in the lower abdomen, testicles, and penis. Prostatitis is mostly caused by bacterial or viral infection, and there are also cases of autoimmunity or other unknown reasons. Most of the infection occurs in the interstitium, and it is causal and interactive with the chronic congestion of the gland. Therefore, it is difficult to heal after a long time.

[0003] Prostatitis...

Examples

preparation example Construction

[0032] The preparation method of Chinese medicine composition of the present invention comprises the steps:

[0033] a. Achyranthes bidentata and Atractylodes macrocephala are crushed through a 10-mesh sieve, epimedium and centella asiatica are broken into short sections of 1-5 cm, put into containers, and the mass concentration of 4-6 times the dry weight of medicinal materials is added to 30-70% the ethanol, airtight and let it soak for 8-10 hours, transfer it to a percolator, extract 40-45 hours with ethanol with a mass concentration of 80-100 times the dry weight of medicinal materials and 30-70%, and collect the percolation extract ;

[0034] b. The above-mentioned percolation extract is filtered, and the filtrate is vacuum spray-dried at 30-50° C. to form a powder to obtain the traditional Chinese medicine composition of the present invention.

[0035] The application of the traditional Chinese medicine composition of the invention is the application in the preparation ...

Embodiment 1

[0038] The preparation of embodiment 1 Chinese medicine composition 1

[0039] 1. Origin and place of origin of medicinal materials

[0040] Epimedium: Epimedium, a plant of the Berberidaceae family Epimedium brevicornum Maxim The dry aerial part of . The place of production is Qujing, Yunnan, provided by Yunnan Yixintang Chinese Herbal Medicine Co., Ltd.

[0041] Centella asiatica: Centella asiatica Centella asiatica (L.) Dried whole herb of Urb. The place of origin is Wenshan, Yunnan, provided by Yunnan Yixintang Chinese Herbal Medicine Co., Ltd.

[0042] Achyranthes bidentata: Achyranthes sichuanensis of Amaranthaceae Cyathula officinalis Kuan dry roots. The place of origin is Sichuan, provided by Yunnan Yixintang Chinese Herbal Medicine Co., Ltd.

[0043] Atractylodes atractylodes: Atractylodes Atractylodes A tractylodes macrocephala Koidz The dry rhizome of . The place of origin is Baoshan, Yunnan, provided by Yunnan Yixintang Chinese Herbal Medicine Co., Lt...

Embodiment 2

[0049] The preparation of embodiment 2 Chinese medicine composition 2

[0050] 1. Origin and place of origin of medicinal materials

[0051] With embodiment 1.

[0052] 2. Prescription

[0053] Epimedium 75 parts, Centella asiatica 5 parts, Achyranthes bidentata 100 parts, Atractylodes macrocephala 4 parts.

[0054] 3. Preparation method:

[0055] Step 1): Weigh the medicinal materials according to the prescription amount. Achyranthes bidentata and Atractylodes macrocephala are crushed through a 10-mesh sieve. Epimedium and Centella asiatica are broken into short sections of 1-5 cm, put into a container, and add 6 times the dry weight of the medicinal materials Ethanol with a mass concentration of 70%, sealed and left to soak for 10 hours, transferred to a percolator, extracted with 70% ethanol with a mass concentration of 100 times the dry weight of medicinal materials for 45 hours, and collected the percolation extract;

[0056] Step 2): Filter the above-mentioned percol...

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