Brain magnetic source intensity positioning method

Abstract

The invention discloses a brain magnetic source intensity positioning method, which comprises the following steps of: building a double-parameter mixed regularization cost function through introducing a time domain smooth regular operator; then, selecting double regularization parameters according to a generalized cross-validation criterion; and solving an original cost function through the proportion of a single regularization item to obtain a solution matrix with the determined brain magnetic source intensity and position, so as to complete the positioning process. The brain magnetic source intensity positioning method provided by the invention has the advantages that the total mean square error is small, and the advantage is more obvious when the noise is higher; all moment mean square errors are basically stabilized at the same level; the noise influence is small; intracerebral neural signals with accurate space time and smooth time domain can be obtained through rebuilding according to the method; and the precise positioning of a brain magnetic source is realized.

Description

technical field [0001] The invention relates to the technical field of biological information, in particular to a method for locating the strength of a brain magnetic source. Background technique [0002] It is an important problem in the study of magnetoencephalography when retrieving and locating the spatial activity position of the magnetic source according to the apparent magnetic field strength of the brain. It is essentially a nonlinear optimization inverse problem. In evolution positioning, a linear method is often used to approximate nonlinear problems. In the prior art, magnetic brain source imaging technology is used to locate the magnetic source of the brain. The traditional minimum norm estimation method (MNE, minimumnormestimate) is the most representative source imaging method. The premise that there are only local neuron activities at all times, add l to the underdetermined linear equation 2 Norm constraints, to solve a current density distribution image wit...

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Problems solved by technology

[0010] However, the disadvantages of this magnetic brain source method are: 1. For continuous MEG measurement signals, there is no overall consideration of the influence of noise, resulting in poor accuracy of the estimated sou

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