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Application of tangeretin in preparation of medicine or health-care product for preventing and treating oral cancer

A technology for citrus peeling and health care products, which is applied in the application field of citrus peeling in the prevention and treatment of oral cancer drugs or health care products, can solve the problems such as the prevention and treatment of oral tumors that have not been seen, and achieves convenient consumption, application, potential Easy-to-obtain results with few side effects

Inactive Publication Date: 2015-12-16
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, tangeretin has been confirmed to have anti-tumor, anti-virus, anti-radiation, hypoglycemic, neuroprotective and other biological activities. For the prevention and treatment of oral tumors

Method used

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  • Application of tangeretin in preparation of medicine or health-care product for preventing and treating oral cancer
  • Application of tangeretin in preparation of medicine or health-care product for preventing and treating oral cancer
  • Application of tangeretin in preparation of medicine or health-care product for preventing and treating oral cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the application of Tangeretin in toothpaste

[0029] The raw materials of toothpaste include (by mass fraction): tangeretin 0.01%, sodium hydrogen phosphate 44%, sodium carboxymethylcellulose 1.0%, silicon dioxide 2.0%, glycerin 15%, carrageenan 0.3%, laurel Sodium sulfate 1.5%, sodium saccharin 0.1%, essence 1%, ethyl p-hydroxybenzoate 0.01%, distilled water 35.08%.

[0030] Toothpaste can be prepared by the conventional drug toothpaste process: put glycerin and sodium carboxymethylcellulose into the glue pot, moisten and stir, then add dissolved sodium saccharin, distilled water, etc. and continue stirring to make a uniform translucent sticky glue, let it stand Let it fully dissolve and swell before use. Put the remaining raw materials and the prepared glue into the blocking pot, and mix them by mechanical stirring to make it have a certain viscosity. Thin tube of appropriate paste. The paste is ground to make it uniform, fine and stable, then vacuum ...

Embodiment 2

[0031] Embodiment 2: the application of Tangeretin in mouthwash

[0032] Mouthwash composition raw materials (by mass fraction): Tangeretin 0.01%, food grade ethanol 10%, sorbitol 20%, hydrogenated castor oil 1%, sodium saccharin 0.01%, essence 0.6%, ammonium hexafluorosilicate 0.2% , 68.18% distilled water.

[0033] Mouthwash can be prepared by conventional mouthwash technology: add tangeretin, sorbitol, hydrogenated castor oil, and hexasilicic acid in proportion to the mixing pot and stir for 10 minutes, then add food-grade ethanol and stir for 5 minutes, and finally add the remaining raw materials Mix well, and take a sample of the product after passing the test.

Embodiment 3

[0034] Embodiment 3: the application of Tangeretin in tooth powder

[0035] Raw materials for tooth powder (by mass fraction): Tangeretin 0.01%, calcium carbonate 80%, sodium carboxymethylcellulose 0.3%, sodium saccharin 0.3%, sodium lauryl sulfate 2.0%, menthol 2%, sorbic acid Alcohol 15.39%.

[0036] Tooth powder can be prepared by conventional tooth powder process: add orange peelin, calcium carbonate, sodium carboxymethyl cellulose, sodium lauryl sulfate, sodium saccharin and other raw materials into the mixer in proportion and mix them evenly, then add menthol and sorbitol Stir for 20 minutes, and obtain the product after sampling and testing are qualified.

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Abstract

The invention provides an application of tangeretin in preparation of a medicine or health-care product for preventing and treating oral cancer. Experiments on reproduction prevention of human oral epidermoid carcinoma cells by monomer compounds nobiletin, naringenin and tangeretin in fruits and peels of citrus plants of rutaceae family indicate that the nobiletin, naringenin and tangeretin have certain inhibiting effects on reproduction of human oral epidermoid carcinoma cells, wherein the tangeretin has a most remarkable effect on inhibiting reproduction of oral carcinoma cells, can be used for preparing health-care products having effects of preventing and treating oral carcinoma, and is suitable for large-scale popularization application.

Description

technical field [0001] The present invention relates to the technical field of application of compounds, more specifically, to the technical field of application of citrus flavonoids, in particular to the application of tangeretin in drugs or health products for the prevention and treatment of oral cancer. Background technique [0002] Oral cancer is one of the common malignant tumors in the head and neck, accounting for about 3% of systemic malignant cancers and seriously endangering human health. Oral squamous carcinoma, also known as oral epidermal carcinoma, accounts for 90% of oral cancers. At present, the treatment of oral cancer is mainly based on surgery, supplemented by radiotherapy and chemotherapy, but these will cause oral and maxillofacial tissue and organ defects, resulting in dysfunction of speech, chewing, swallowing, etc., seriously affecting the quality of life of patients. In addition, the prognosis of oral squamous carcinoma patients after treatment is p...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K8/49A61K8/73A61K8/92A61K8/97A61K8/60A61P35/00A61Q11/00
Inventor 陈谷王宏
Owner SOUTH CHINA UNIV OF TECH
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