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Sterile zinc-based montmorillonite Band-Aid as well as preparation method and application thereof

A zinc-based montmorillonite and band-aid technology, which is applied in the field of medicine to prevent reproduction and prevent wound infection.

Active Publication Date: 2015-12-16
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the modification of montmorillonite into zinc-based montmorillonite for the preparation of zinc-based montmorillonite sterile external patches has not been reported

Method used

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  • Sterile zinc-based montmorillonite Band-Aid as well as preparation method and application thereof
  • Sterile zinc-based montmorillonite Band-Aid as well as preparation method and application thereof
  • Sterile zinc-based montmorillonite Band-Aid as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0034] A preparation method of zinc-based montmorillonite aseptic band-aid, comprising the following steps:

[0035] (1) Grind zinc-based montmorillonite into fine powder, pass through a 500-mesh medicinal sieve, put it into a dry heat sterilizer, sterilize at a temperature of 170-180°C, and sterilize for 180-240 minutes. Standby at room temperature;

[0036] (2) Get the hydroxypropyl cellulose of formula quantity, pulverize, pass 100 mesh medicinal sieves; Carry out sterilization in the ethylene oxide sterilization cabinet, the pressure is 35~50Kpa, and sterilization time is 3~6h, in Standby at room temperature;

[0037] (3) Take the glycerin and polyethylene glycol 1500 of formula quantity and sterilize at 121-125° C. for 30-60 minutes, transport them to sterilized tanks for storage, and store them at room temperature for later use;

[0038] (4) Put the material obtained in step (1) and step (2) into the sterilized tank in step (3) and add purified water; stir and mix even...

experiment example 1

[0058] Experimental example 1: Prescription amount screening experiment

[0059] Zinc-based montmorillonite is prepared by modifying montmorillonite, which belongs to a kind of mineral medicine. Since the particles of mineral medicine are relatively thick, if there are larger particles in the preparation of band-aids, it is easy to cause secondary damage to the skin and damage the wound. Healing produces unfavorable factors, secondly if there are larger particles, uniformity problems are produced in the production coating process, for this reason the present invention designs the following prescriptions, with molding and particle size as evaluation indicators, test according to the preparation method of Example 1, and screen Test, see Table 1.

[0060] Table 1 Prescription dosage screening (parts by mass)

[0061]

[0062] Results: Prescription 1: short molding time, uneven coating, particle size less than 180μm;

[0063] Prescription 2: The molding time is slightly longe...

experiment example 2

[0078] Experimental example 2: Zinc-based montmorillonite sterilization experiment

[0079] The active ingredient zinc-based montmorillonite of the preparation described in the present invention is modified by montmorillonite, and is a layered mineral composed of extremely fine-grained hydrous aluminosilicate. The research on the sterilization method of zinc-based montmorillonite is to ensure that the zinc-based montmorillonite On the premise that the montmorillonite band-aid drug meets the quality standards, it is a major innovation breakthrough to ensure that the zinc-based montmorillonite band-aid drug can be used safely.

[0080] The comparison of different dry heat temperatures and dry heat times on the dry heat sterilization effect of zinc-based montmorillonite is shown in Table 3:

[0081] Table 3 Zinc-based montmorillonite dry heat sterilization effect comparison

[0082]

[0083] It can be analyzed from Table 3 that:

[0084] 1. Under the conditions of dry heat t...

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Abstract

The invention relates to a sterile zinc-based montmorillonite Band-Aid as well as a preparation method and an application thereof. The Band-Aid comprises base cloth, an inner pad and a bonding part, wherein a medicament is attached to the inner pad. The Band-Aid is characterized in that the medicament contains zinc-based montmorillonite. Free zinc ions and montmorillonite can be dissociated from the used zinc-based montmorillonite, the medicament side of the Band-Aid is pasted to a skin wound, and the montmorillonite dissociated from the zinc-based montmorillonite of the Band-Aid can form gel after encountering blood, so that bleeding is stopped quickly; the formed gel can be used as a protection layer on the surface and the periphery of the wound to prevent external bacteria from invading; the zinc ions dissociated from the zinc-based montmorillonite have antibacterial and anti-inflammatory effects and has astringent and healing effects on damaged skin.

Description

technical field [0001] The invention relates to a sterile band-aid and its preparation method and application, in particular to a zinc-based montmorillonite sterile band-aid and its preparation method and application, belonging to the technical field of medicine. Background technique [0002] Band-aid is the most commonly used surgical drug in people's life. Band-aid, also known as "hemostatic plaster", has the functions of hemostasis and skin protection. It consists of a long strip of adhesive plaster with a small piece of drug-soaked gauze attached in the middle. Due to its structural limitation, Band-Aid can only be used for emergency treatment of small pieces of trauma, so as to temporarily stop bleeding and protect the wound surface. But it should be noted that the time of use should not be too long. If you use it for too long, the adhesive tape on the outside of the Band-Aid will not breathe. It will make the wound and the skin around the wound turn white and softe...

Claims

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Application Information

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IPC IPC(8): A61L15/18A61L15/42A61L15/44A61F13/02
Inventor 乔敏袁武杰刘钢李红新孟震晓
Owner SHANDONG SBOND PHARMA
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