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Pharmaceutical preparation for treating transient ischemic attack with syndrome of blood stasis in orifices and preparation method of pharmaceutical preparation

A technology for transient cerebral ischemia and pharmaceutical preparations, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc. Long-term problems, to prevent platelet aggregation, improve brain microcirculation, improve the body's blood circulation effect

Inactive Publication Date: 2015-12-23
冉宇欣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Western medicine treats transient cerebral ischemia for a long period of time, and has relatively large toxic and side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0075] Wherein, when the dosage form of the pharmaceutical preparation is syrup, its preparation method comprises the following steps:

[0076] In the first step, mix hippocampus, Phnom Penh Lotus, Rhodiola rosea, seabuckthorn, weed grass, sheep red mutton and angelica according to the stated ratio, and add ethanol with an alcohol concentration of 80% to 90% that is 4 to 6 times that of the mixture, Heating and reflux extraction 2 to 4 times, each reflux extraction for 2 hours to 3 hours, combined extracts, centrifuged with a tube centrifuge to remove impurities, and concentrated the removed extracts under reduced pressure at 60°C to 70°C When the temperature reaches 60°C, the relative density is 1.05-1.10. The concentrated liquid is dried with a spray dryer, and then crushed into 100-200 mesh to obtain a dry powder;

[0077] In the second step, mix Dendrobium, Spatholobus Spatholobus, Wangbuliuxing, Chinese rose, Shujincao, oyster and mother-of-pearl according to the stated r...

Embodiment 1

[0090] Embodiment 1 syrup

[0091] The preparation process of the syrup of the present invention is: get Rhizoma Chuanxiong 180g, Shuikuying 130g, Curcuma 230g, Curcuma longa 160g, Radix yam 220g, Xia Wu 190g, Salvia miltiorrhiza 140g, Sijiqing 170g, Safflower 220g, Achyranthes bidentata 240g, Dendrobium 250g , Caulis Spatholobus 200g, Wangbuliuxing 190g, Chinese rose 200g, Shujincao 240g, oyster 220g, mother-of-pearl 190g, magnet 210g, jujube seed 250g, valerian 160g, red vine 280g, Gastrodia elata 190g, false forsythia 140g, earthworm 120g, silkworm 180g, calamus 170g, grass lingzhi 230g, white peony root 200g, hippocampus 190g, lotus 210g, rhodiola 150g, seabuckthorn 120g, weed grass 180g, sheep red mutton 210g and angelica 170g;

[0092] In the first step, mix hippocampus, Phnom Penh Lotus, Rhodiola rosea, seabuckthorn, weed grass, sheep red mutton and angelica according to the stated ratio, add ethanol with an alcohol concentration of 6 times that of the mixture, and heat...

Embodiment 2

[0096] Embodiment 2 oral liquid

[0097] The preparation process of the oral liquid of the present invention is: get Rhizoma Chuanxiong 160g, Shuikuying 170g, Curcuma 220g, Curcuma longa 140g, Radix yam 200g, Xia Wu 170g, Salvia miltiorrhiza 120g, Sijiqing 180g, Safflower 240g, Achyranthes bidentata 250g, Dendrobium 270g , Caulis Spatholobus 170g, Wang Buliuxing 100g, Rose 240g, Shujincao 260g, Oyster 170g, Mother of Pearl 230g, Magnet 240g, Ziziphus 260g, Valerian 220g, Grass Red Vine 300g, Gastrodia elata 200g, False Forsythia 210g, earthworm 110g, silkworm 160g, calamus 220g, grass lingzhi 240g, white peony 200g, hippocampus 250g, lotus 200g, rhodiola 180g, seabuckthorn 140g, weed grass 190g, sheep red mutton 200g and angelica 170g;

[0098] The first step is to mix False Forsythia, Earthworm, Silkworm, Shichangpu, Caolingzhi, Paeoniae Alba, Hippocampus, Phnom Penh, Rhodiola rosea and Hippophae rhamnoides, and add alcohol concentration of 80% relative to the mixture 7 times...

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PUM

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Abstract

The invention discloses a pharmaceutical preparation for treating transient ischemic attack with syndrome of blood stasis in orifices and a preparation method of the pharmaceutical preparation. The pharmaceutical preparation consists of the following medicinal raw materials: ligusticum wallichii, veronica undulate, curcuma aromatica, radix curcumae longae, rhizoma dioscoreae, corydalis amabilis, salvia miltiorrhiza, Chinese holly, safflower, root of bidentate achyranthes, dendrobe, caulis spatholobi, cowherb seed, rosa chinensis, beefwood-like clubmoss herb, oyster, mother of pearl, magnetite, seed of wild jujube, valeriana officinalis, shuteria pampaniniana, gastrodia elata, duranta erecta, earthworm, bombyx batryticatus, rhizoma acori graminei, pika droppings, radix paeoniae alba, hippocampus japonicus, goodyera kwangtungensis tso, rhodiola rosea, hippophae rhamnoides, hispid arthraxon, pimpinella thellungiana and angelica. The pharmaceutical preparation has the beneficial effects that the pharmaceutical preparation has functions of promoting blood circulation and removing stasis, opening orifices and unblocking meridian obstruction; the pharmaceutical preparation is mainly used for treating transient ischemic attack with syndrome of blood stasis in orifices, and the pharmaceutical preparation is conducive to dilating blood vessels, improving cerebral microcirculation, preventing platelet aggregation, improving blood circulation in a body and like high risk factors; and the pharmaceutical preparation has the advantages of being rapid to take effect, high in cure rate, concrete in curative effect, short in treatment course, free from toxic or side effect, low in reoccurrence rate and the like.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical preparation for treating transient ischemic attack of blood stasis blocking orifice type and a preparation method thereof. Background technique [0002] Transient ischemic attack (TIA) is a transient insufficiency of blood supply in the carotid artery or vertebral-basilar artery system, causing focal cerebral ischemia and sudden, transient, reversible neurological dysfunction. The attack lasts for several minutes, and more than 2 hours often leaves slight neurological deficits, or CT and MRI show signs of brain tissue ischemia. TIA is more common in 34-65 years old, 25.3% of them are over 65 years old, more men than women. The onset is sudden, mostly in the case of body position change, hyperactivity, sudden rotation or flexion and extension of the neck. The onset has no aura, and there are transient signs of nervous system localization. Gen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P9/10A61K33/26A61K35/24A61K35/60A61K35/618A61K35/62A61K35/64
Inventor 冉宇欣
Owner 冉宇欣
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