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Processes for the preparation of enamines

A technology of mixtures and reaction zones, used in chemical instruments and methods, preparation of amino compounds, preparation of organic compounds, etc.

Inactive Publication Date: 2015-12-23
DOW AGROSCIENCES LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The presently known methods of preparing such thioenamines are not efficient for the preparation of such enamines for several reasons - there are problems in preventing thermal degradation of the thioenamines, while the potassium carbonate used is an effective drying agent, But filtering such desiccants in larger-than-lab-scale production is problematic

Method used

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  • Processes for the preparation of enamines
  • Processes for the preparation of enamines
  • Processes for the preparation of enamines

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Embodiment

[0120] The examples are for illustrative purposes only, and should not be construed as limiting the present invention disclosed in this document to only the embodiments disclosed in these examples.

[0121] 1. Preparation of 3-methylthiobutyraldehyde from crotonaldehyde (1).

[0122]

[0123] A three-liter (L) 3-neck round bottom flask equipped with magnetic stirring, temperature probe, addition funnel, distillation head, protected with nitrogen, and discharged to the bleach scrubber was charged with 100 mL of toluene, and then charged with 84 g (1.39 mol ) Glacial acetic acid, and then filled with 61g (0.86mol) crotonaldehyde. Another 100 mL of toluene was used as a solvent wash during the addition of acetic acid and crotonaldehyde. The reaction mixture was cooled in an ice-water bath, and then 500 g (0.906 mol) of 12.7% by weight sodium methyl mercaptan aqueous solution was added via an addition funnel over 67 minutes (min). During the addition of the thiolate solution, the int...

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Abstract

The invention disclosed in this document is related to the field of processes for the preparation of enamines wherein R1, R2, R3, R4, R5, and further information are disclosed herein.

Description

[0001] The application of the present invention is a divisional application based on the patent application whose filing date is November 23, 2011, the application number is 201180058182.2 (the international application number is PCT / US2011 / 061986), and the invention title is "method for preparing enamine". [0002] Cross references to related applications [0003] This application claims the priority of U.S. Provisional Application 61 / 419,277 filed on December 3, 2010. The entire content of this provisional application is incorporated into this application by reference. Technical field [0004] The invention disclosed in this document relates to the field of methods for preparing enamines. Background technique [0005] Enamine is a very useful molecule. They have been used in a variety of reactions, such as electrophilic substitution and addition, oxidation and reduction, and cycloaddition (J.Kang, YRCho, andJ.H.Lee, Bull.KoreanChemSoc.Vol.13, No.2) , 1992). [0006] Early methods ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D295/084
CPCC07D295/084C07D207/08C07C209/52C07C323/27
Inventor D.C.布兰德T.W.托伊赞R.B.伦格J.R.麦康内尔
Owner DOW AGROSCIENCES LLC