A kind of trifluridine compound and its pharmaceutical composition
A compound and drug technology, applied in the field of new Trifluridine crystal form and its preparation method and pharmaceutical composition, can solve the problem of no literature report and the like
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Embodiment 1
[0034]Add 1.5g (5.07mmol) Trifluridine primary product into 10mL methyl acetate, beat at 20°C for 20min, filter, add the filtered solid into 3mL mixed solvent of water and methanol (1:1 V / V), heat to 60°C The solid was fully dissolved until clear, then cooled to 10° C., left to stand for crystallization for 3 hours, filtered, collected and dried to obtain 1.06 g of white solid, yield: 70.7%.
Embodiment 2
[0036] Add 1.5g (5.07mmol) Trifluridine primary product into a mixed solvent composed of 7.5mL ethyl acetate and 7.5mL n-heptane, beat at 25°C for 30min, filter, add the filtered solid to water and ethanol (2:1V / V ) in 3mL mixed solvent, heated to 65°C to fully dissolve the solid until clear, then cooled to 16°C, stood for crystallization for 3.5h, filtered, collected the solid, and dried to obtain 1.13g of white solid, yield: 75.3%.
Embodiment 3
[0038] Add 1.5g (5.07mmol) Trifluridine primary product into a mixed solvent composed of 5.7mL butyl acetate and 14.3mL n-hexane, beat at 30°C for 45min, filter, add the filtered solid to water and n-butanol (3:1V / V ) in 3mL mixed solvent, heated to 75°C to fully dissolve the solid until clear, then cooled to 20°C, stood for crystallization for 3.5h, filtered, collected the solid, and dried to obtain 1.1g of white solid, yield: 73.3%.
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