Orally-administered decoction and externally-applied poultice for treating cholelithiasis, and preparation method of externally-applied poultice

A technology of decocting liquid and cholelithiasis, which is applied in the field of traditional Chinese medicine, can solve the problems of residual liver stones and restrictions on the development of surgical operations, achieve definite curative effect, good potential and development prospects, and reduce the effect of bile duct infection

Inactive Publication Date: 2016-01-06
王栩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of cholelithiasis is still dominated by surgery. However, factors such as complex anatomical variation during surgery, bile duct injury, damage to the liver caused by surgery, residual and recurrence of postoperative stones restrict the development of surgery, and it is difficult to fundamentally solve the problem. Prevention and treatment of cholelithiasis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0072] The present invention also provides a preparation method of the above-mentioned externally applied cataplasm, specifically:

[0073] In the first step, each bulk drug is pulverized into powder respectively, and passed through a 100-mesh sieve, so that the amount of fine powder passing through the 100-mesh sieve reaches 30%, and the raw material fine powder passing through the 100-mesh sieve is collected for subsequent use;

[0074] In the second step, put the remaining particles after sieving into 70% to 80% ethanol with an alcohol concentration of 2 to 4 times its volume, extract 3 times with ultra-high pressure, and use alcohol amounts of 8 times, 8 times and 6 times, the pressure is 300MPa, and the pressure is maintained for 3 minutes each time, the extracts are combined, the ethanol is recovered, and the extract is concentrated to a relative density of 1.20 (60°C thermal measurement);

[0075] In the third step, the sieved raw material fine powder collected in the f...

Embodiment 1

[0079] Embodiment 1 decoction

[0080] Senna leaves 22g, galangal 16g, water gardenia 18g, dried tangerine peel 15g, money grass 28g, Achyranthes sichuanensis 20g, magnolia officinalis 12g, rhubarb 19g, Selaginella 25g, coix seed 15g, sealwort 17g, verna 14g, stone Mix Wei 25g, Mimosa 18g, Guazijin 15g, Codonopsis 25g and Gorgon 17g together, add water 8 times its mass, boil it and decoct it for 3 hours, filter the decoction, add the filter residue relative to its mass 4 times of water, after boiling, decoct with slow fire for 3 hours, filter the decoction, combine the filtered decoction, and concentrate into a 1g / ml medicinal liquid.

[0081] Acute Toxicity Test of Drug Solution

[0082] ICR strain mice were gavaged with the medicinal solution provided in Example 1, and LD was not detected 50 , administered twice within 24 hours, observed for 14 days, none of the mice died, and the maximum drug dose tested was 65.8g / kg, which was about 329 times the clinical human dose, and...

Embodiment 2

[0085] Embodiment 2 poultice

[0086] Take 17g of Rhizoma Imperatae Root, 20g of Corydalis Corydalis, 15g of Piper Cucumber, 14g of Myrrh, 28g of Polygonum cuspidatum, 15g of Herba Vermilione, 18g of Gentiana, 17g of Artemisia annua, 16g of Bamboo Yellow, 14g of Lilygrass, 14g of Shimangcao and 15g of White Chrysanthemum Grind them into powder respectively, pass through a 100 mesh sieve, so that the amount of fine powder that can pass through the 100 mesh sieve reaches 30%, collect the raw material fine powder that passes through the 100 mesh sieve for later use, and put the remaining particles after sieving into 3 times alcohol concentration is 80% ethanol, ultra-high pressure extraction 3 times, the amount of alcohol used is 8 times, 8 times, and 6 times the weight of the particles respectively, the pressure is 300MPa, and the pressure is kept for 3 minutes each time, the extracts are combined, and the ethanol is recovered , concentrated to an extract with a relative density...

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PUM

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Abstract

The invention provides an orally-administered decoction and an externally-applied poultice for treating cholelithiasis. The orally-administered decoction and the externally-applied poultice have the advantages that precise cholelithiasis treatment and prevention effect is achieved; due to non-invasion property and low side effect of traditional Chinese medicine as well as compressive synergistic effects such as effect on biliary tract dynamics, proportion change of components in bile, bile duct infection reduction and application in a perioperative period, the traditional Chinese medicine has good potential and promising development prospect in cholelithiasis treatment.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to an oral decoction and an externally applied cataplasm for treating cholelithiasis. Background technique [0002] Cholelithiasis is generally caused by abnormal bile components and biliary motor dysfunction. It is a common and frequently-occurring disease, often manifested as abdominal pain, nausea, vomiting, right upper quadrant tenderness, etc., and seriously endangers human health. With the improvement of people's living standards, the etiology and types of cholelithiasis are also constantly changing and increasing. [0003] Modern medicine believes that the etiology of cholelithiasis is very complex, related to age, gender and obesity. Its pathogenesis is mainly the condensation formed in the bile duct, which belongs to one of the digestive system diseases. At present, the treatment of cholelithiasis is still dominated by surgery. However, factors such a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61K36/899A61K9/70A61P1/16
Inventor 不公告发明人
Owner 王栩
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