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A kind of natural new compound and its preparation and application
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A natural compound and drug technology, applied in the field of medicine, can solve the problem of anti-tumor activity of saponin monomer components without marijuana, and achieve strong anti-cancer activity and growth-inhibiting effect
Active Publication Date: 2017-03-29
YUNNAN PHYTOPHARML
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At present, there is no report on the isolation of cannabinoid saponin C from cannabis, and there is no report of cannabinoid saponin C in the online version of the chemical abstract database Scifinder data search and literature search. It is a new natural compound and has not been carried out so far. Reports on the in-depth research on the activity of monomeric components of cannabis saponins, especially reports on the anti-tumor activity of monomeric components of cannabis saponins
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Embodiment 1
[0018] Example 1: Component Separation
[0019] Cannabis medicine 10Kg, crushed and extracted 3 times with 70% ethanol under heat reflux, 1250g of concentrated extract under reduced pressure, eluted with chloroform-methanol gradient through silica gel column chromatography, the gradient is chloroform:methanol volume ratio is 50:1 , 30:1, 20:1, 10:1, 5:1, 3:1, 1:1, tested by TLC, the same parts were merged together and divided into 6 parts, numbered Fr. 2. Fr.3, Fr.4, Fr.5, Fr.6; among them, Fr.3 was separated and purified by silica gel column chromatography and Sephadex column chromatography to obtain 500 mg of the compound, which was named as cannabis drug saponin C.
Embodiment 2
[0020] Example 2: Structural Identification of Cannabis Saponin C
[0021] Cannabis saponin C is a white powder, soluble in methanol. In order to determine its chemical structure, the following spectra were made for cannabis saponin C: (1) spectrum, optical rotation spectrum, ultraviolet spectrum and infrared spectrum, (2) nuclear magnetic resonance one-dimensional spectrum Done 1 H. 13 C and DEPT spectra, (3) HMBC, HSQC and 1 H- 1 H COZY spectrum, (4) NOE experiment.
[0022] The entire structure identification process is described in detail below: According to the one-dimensional nuclear magnetic spectrum 1 H. 13 C NMR and DEPT spectrum, preliminarily judged to be a triterpene saponin, through literature research, the triterpene saponin A (DolirosideA) that Pu Xiangyu et al. similarities. According to the quasi-molecular ion peak 671 ([M+Na]+) given by ESI+-MS, HRESIMS ([M+Na]+, m / z 671.3769) and NMR data, its molecular formula is C 36 h 56 o 10 , with an unsaturat...
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Abstract
The invention discloses a novel natural compound and preparation and application thereof. The compound is novel in structure and high in anti-tumor activity and is hemp medicine separated from dolichos falcate klein roots. The invention further discloses a preparation method of the novel natural compound. The compound is obtained through alcohol extraction of hemp medicine coarse powder, vacuum concentration, column chromatography on silica gel, chloroform-methyl alcohol gradient elution and separation and purification. The novel compound is white powder seen from the appearance and is triterpene saponin, the molecular formula is C36H56O10, and the novel compound is named hemp medicine saponin C.
Description
technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a new natural compound structure and its preparation method and application. Background technique [0002] Cannabis is the root of Dolichos falcata Klein, a plant of the genus Fabaceae. It is commonly known as Mali Ma, Ma Sanduan, and Bean Leaf Baibu Huanyang. It is used medicinally in Yunnan, Guizhou and other places. effect. There are few studies on the chemical composition and pharmacological activity of cannabis medicine through literature review. Pu Xiangyu et al. have conducted research on the chemical composition of it and found that the main saponin component is cannabis medicine saponin A [Pu Xiangyu et al., Triterpenoids of Cannabis Medicine Saponins (1), Yunnan Plant Research 1984, 6(3)321-324]. In the 1970s and 1980s, Guiyang Medical College, Huang Houpin and others conducted a rough study on the anticancer effect of total saponins of marijuana. At pres...
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