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Hypolipidemic drug combination and application thereof

A blood lipid-lowering drug and composition technology, which is applied in the application field of treating hyperlipidemia, can solve the problems of complex composition of Chinese patent medicines and difficult control of active ingredients, and achieve the effect of improving blood rheology and inhibiting blood lipid elevation

Inactive Publication Date: 2016-01-13
成都普瑞法科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complex composition of most Chinese patent medicines, it is difficult to control the active ingredients, which brings many problems to the quality control and curative effect of the products

Method used

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  • Hypolipidemic drug combination and application thereof
  • Hypolipidemic drug combination and application thereof
  • Hypolipidemic drug combination and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 5.25g of EPA, 9.75g of EGCG and 10g of commercially available microcrystalline cellulose, and pass through a 60-mesh sieve after mixing. Spray 6ml of 95% ethanol into the resulting mixture, stir and mix evenly, pass through a 30 mesh sieve again to obtain small particles, dry at 55°C for 1.5 hours, and pack into No. 1 capsules to make 100 capsules.

Embodiment 2

[0031] Weigh 7.5g of EPA and 7.5g of EGCG respectively, add 15g of cornstarch, 10g of microcrystalline cellulose, and povidone K 30 3g, 7g of sodium carboxymethyl starch were mixed and passed through an 80-mesh sieve. Add 10ml of 95% ethanol to the resulting mixture, stir and mix evenly, pass through a 30-mesh sieve to prepare wet granules, then dry in an oven at 45°C for 1.5 hours, and turn the granules once every 30 minutes. After the dried granules are sieved through a 20-mesh sieve for granulation, an appropriate amount of magnesium stearate is added to mix evenly, and pressed into 100 pieces to prepare tablets.

Embodiment 3

[0033] Weigh 7.5g of EPA and 7.5g of resveratrol respectively, add 10g of cornstarch, 15g of microcrystalline cellulose, and povidone K 30 3g, 7g of sodium carboxymethyl starch were mixed and passed through an 80-mesh sieve. Add 10ml of 95% ethanol to the resulting mixture, stir and mix evenly, pass through a 30-mesh sieve to prepare wet granules, then dry in an oven at 45°C for 1.5 hours, and turn the granules once every 30 minutes. After the dried granules are sieved through a 20-mesh sieve for granulation, an appropriate amount of magnesium stearate is added to mix evenly, and pressed into 100 pieces to prepare tablets.

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Abstract

The invention relates to a hypolipidemic drug combination formed by combining polyunsaturated fatty acid with plant polyphenol, in particular to hypolipidemic drug using EPA and EGCG or resveratrol as main active ingredients. Experimental studies show that the combination can remarkably lower blood lipid level and improve hemorheology and has remarkable effect on regulating blood lipid and preventing and treating diseases related to blood lipid metabolism abnormality. The combination is extensive in raw material source, low in cost and worthy of popularization and application.

Description

technical field [0001] The invention relates to the preparation of a blood lipid-lowering pharmaceutical composition and its application in treating hyperlipidemia. Background technique [0002] In recent years, due to great changes in people's living standards, work and life pressure, ecological environment, and dietary structure, the number of people suffering from diabetes, hyperlipidemia, and cardiovascular and cerebrovascular diseases has continued to increase, and the trend is increasing year by year. Hyperlipidemia can easily induce coronary heart disease, fatty liver, hyperglycemia, obesity, etc., which are significantly harmful to human health. Therefore, it is of great significance for clinical treatment to actively administer antihyperlipidemic drugs that are effective and have small adverse reactions. At present, there are many types of clinically common blood lipid-lowering drugs. For most clinicians, more attention is paid to Western medicine treatment, such a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P9/12A61P9/10A61P3/04A61P3/06A61P9/00A61P3/10A61P1/16A61K31/05A61K31/202
Inventor 胡云岭罗明锋郭建龙邝彬杨金辉谢海峰谢期林
Owner 成都普瑞法科技开发有限公司
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