A kind of anti-collapse calcium phosphate bone cement and its preparation method and application

A calcium phosphate bone cement, anti-collapse technology, applied in medical science, prosthesis and other directions, can solve the problems of delaying CPC curing time, hindering CPC hydration speed, hindering bone cement crystallization, etc., to achieve good clinical application effect, good biological Medical properties, the effect of improving anti-collision properties

Active Publication Date: 2018-05-15
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because HPMC forms a network structure similar to a film and wraps the cement, hinders or slows down the hydration rate of CPC, and hinders the crystallization of bone cement, so HPMC will reduce the strength of bone cement (J Pourchez, A Peschard, P Grosseau, et al. HPMC and HEMC influence on cement hydration. Cement and Concrete Research, 2006, 36:288-294.)
In a word, although these additives can improve the collapse resistance of CPC to a certain extent, they are all investigated in a short period of time (within 10 minutes), and most of them delay the curing time of CPC and reduce the implant quality. The question of strength

Method used

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  • A kind of anti-collapse calcium phosphate bone cement and its preparation method and application
  • A kind of anti-collapse calcium phosphate bone cement and its preparation method and application
  • A kind of anti-collapse calcium phosphate bone cement and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Fenugreek gum (the mass is 3.0% of the tetracalcium phosphate-calcium hydrogen phosphate bone cement powder) was evenly mixed with the tetracalcium phosphate-calcium hydrogen phosphate bone cement powder. Then, the deionized aqueous solution was uniformly mixed with the calcium phosphate bone cement containing fenugreek gum prepared in this example at a liquid-solid ratio of 0.5mL / g, and the paste was injected into a mold and placed in simulated body fluid at 37°C . The comparison of physical and chemical properties between the anti-collapse calcium phosphate bone cement containing fenugreek gum prepared in this example and the calcium phosphate bone cement without galactomannan vegetable glue is shown in Table 1:

[0027] Table 1

[0028]

[0029] Note: "-" indicates the calcium phosphate bone cement without galactomannan vegetable glue; "+" indicates the calcium phosphate bone cement with galactomannan vegetable glue added, the same as the following table. The co...

Embodiment 2

[0032] The guar gum (the mass is 2.0% of the tetracalcium phosphate-β-tricalcium phosphate-dicalcium phosphate bone cement) was evenly mixed with the tetracalcium phosphate-β-tricalcium phosphate-dicalcium phosphate bone cement. Then uniformly mix the 0.125mol / L sodium dihydrogen phosphate solution with the calcium phosphate bone cement containing guar gum prepared in this example according to the liquid-solid ratio of 0.4mL / g, and mix it into a paste and inject it into the mold after forming. In simulated body fluid at 37°C. The comparison of physical and chemical properties between the anti-collapse calcium phosphate bone cement containing guar gum prepared in this example and ordinary calcium phosphate bone cement is shown in Table 2:

[0033] Table 2

[0034]

[0035] Compared with the ordinary calcium phosphate bone cement, the anti-collapse calcium phosphate bone cement containing guar gum prepared in this example has an anti-collapse coefficient of 89±3%, which is m...

Embodiment 3

[0037] Tara gum (the mass is 1.0% of α-tricalcium phosphate-calcium hydrogen phosphate-calcium carbonate bone cement) was evenly mixed with α-tricalcium phosphate-calcium hydrogen phosphate-calcium carbonate bone cement. Then uniformly mix the 0.25mol / L sodium hydrogen phosphate buffer solution with the calcium phosphate bone cement containing tara gum prepared in this example according to the liquid-solid ratio of 0.5mL / g, and mix it into a paste and inject it into the mold and place it in the In simulated body fluid at 37°C. The comparison of physical and chemical properties between the anti-collapse calcium phosphate bone cement containing tara gum prepared in this example and ordinary calcium phosphate bone cement is shown in Table 3:

[0038] table 3

[0039]

[0040]Compared with ordinary calcium phosphate bone cement, the anti-collapse calcium phosphate bone cement containing tara gum prepared in this example has an anti-collapse coefficient of 84 ± 1%, which is mor...

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Abstract

The invention discloses an anti-collapse calcium phosphate bone cement, which is composed of calcium phosphate bone cement and galactomannan type vegetable glue; 3.0%. The invention also discloses a preparation method and application of the anti-collapse calcium phosphate bone cement. The present invention successfully applies galactomannan-type vegetable glue in calcium phosphate bone cement for the first time, and at the same time meets the requirements of not only significantly improving the anti-collapse performance of calcium phosphate bone cement, but also maintaining the original curing characteristics and The requirement that the hydration product has little effect on its mechanical properties effectively improves the success rate of the operation. The invention not only expands the new medical value of the galactomannan type vegetable glue, but also makes the calcium phosphate bone cement have a wider application prospect.

Description

technical field [0001] The invention relates to a medical material for repairing bone damage, in particular to an anti-collapse calcium phosphate bone cement and its preparation method and application. Background technique [0002] Calcium phosphate bone cement (CPC) is composed of calcium phosphate powder as the main solid phase component, deionized water or aqueous solution or blood as the liquid phase, and the solid phase powder and liquid phase are mixed to form a paste, which occurs at room temperature or at body temperature. Hydration reaction and self-curing, the main product after curing is hydroxyapatite. Because the chemical composition of CPC is similar to the inorganic components of hard tissues such as human bones and teeth, and has good biocompatibility and osteoconductivity, can be shaped arbitrarily, and can be used as a drug sustained-release carrier, it has become a clinical practice. It is one of the hotspots in research and application in the field of bo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/20A61L27/50
Inventor 叶建东刘婧群李继彦
Owner SOUTH CHINA UNIV OF TECH
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