High-strength injectable magnesium phosphate bone cement and preparation method thereof

Abstract

The invention discloses high-strength injectable magnesium phosphate bone cement and a preparation method thereof. The high-strength injectable magnesium phosphate bone cement comprises solid-phase powder and curing liquid, wherein the ratio of the solid-phase powder to the curing liquid is (1.5-3.5) g: 1mL; the solid-phase powder comprises the following components in parts by weight: 50-90 parts of magnesium phosphate salt and 10-50 parts of hydrophosphate, wherein the magnesium phosphate salt comprises trimagnesium phosphate, and the hydrophosphate salt comprises monopotassium phosphate; and the curing liquid is an aqueous solution. The solid-phase powder and the curing liquid are directly mixed to prepare the high-strength injectable magnesium phosphate bone cement. The bone cement has high compressive strength, good injectability and collapse resistance, can prolong the curing time and reduce heat release in the reaction process, and is suitable for being applied to the fields of osteoporosis vertebral compression fracture, spinal fusion and bone repair of other bearing parts.

Description

technical field [0001] The invention belongs to the technical field of bone cement, and in particular relates to a high-strength injectable magnesium phosphate bone cement and a preparation method thereof. Background technique [0002] The proportion of aging population in my country is increasing. Osteoporosis and intervertebral disc degeneration are common senile orthopedic diseases, which are closely related to population aging. Although the human body has a certain self-healing ability, it has limited self-healing ability for critical size or pathological damage, which is often related to implanting bone repair materials. In addition, in the treatment of bone defects in weight-bearing areas, implant fixation supports with high strength are required to assist healing. [0003] Two commonly used bone cements for vertebroplasty are polymethylacrylate (PMMA) and calcium phosphate (CPC). PMMA bone cement has good operability, biocompatibility and mechanical properties and i...

AI Technical Summary

Problems solved by technology

However, magnesium-based bone cement has limited strength and is difficult to apply to load-bearing parts

In recent years, although there have been studies to improve its strength by adding polymers or whisker fibers, the cost of materials has been greatly increased.

Moreover, the magnesium-based bone cement made of magnesium oxide has a high local pH and a large curing heat release, which does not have good biocompatibility.

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