Traditional Chinese medicine composition for treating cancer osseous metastasis

A technology of bone metastasis and composition, applied in the field of medicine, can solve the problems of inability to relieve cancer pain, different pathogenesis, etc., and achieve the effect of prolonging the survival period and improving the quality of life

Inactive Publication Date: 2016-01-27
陈国军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In fact, the pathogenesis of the two is not the same, and drugs that are effective in the treatment of neuropathic pain cannot relieve cancer pain

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0012] Weigh 11 grams of Guizhi, 8 grams of white peony, 8 grams of licorice, 45 grams of Clematis, 12 grams of Bupleurum, 11 grams of Scutellaria baicalensis, 11 grams of tangerine peel, 11 grams of turmeric, 11 grams of paeonol, 11 grams of notopterygium, 11g, Fangfeng 11g, Asarum 3g, Poria 11g, Angelica 11g, Achyranthes bidentata 11g, Chuanduan 11g, Rhubarb 6g, Ligusticum edulis 11g, Vitex 11g and Chuanxiong 11g, crushed , passed through a 100-mesh sieve, and mixed uniformly to obtain a powder.

experiment example

[0014] MTT (purchased from Sigma Company) was dissolved in normal saline, prepared into a working solution of 5 mg / mL, and stored at -20°C; dimethylsulfoxide (DMSO) was produced by Xi'an Chemical Reagent Factory and was analytically pure. Human breast cancer T47D cells were purchased from Shanghai Fengshou Biotechnology Co., Ltd.

[0015] Principle of MTT method

[0016] MTT is an acceptable H + yellow dye. In the mitochondrial respiratory chain of living cells, succinate dehydrogenase and cytochrome C can cleave the tetrazolium ring of MTT to produce blue-purple formazan crystals. Dead cells do not contain this dehydrogenase. The amount of Formazan crystals generated is directly proportional to the number of viable cells, and the DMSO solution of the crystals has a maximum absorption peak at 570nm. Therefore, the effect of the drug on cell proliferation can be evaluated by detecting the amount of formazan crystals.

[0017] Human breast cancer T47D cells were selected as ...

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PUM

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Abstract

The invention relates to a traditional Chinese medicine composition for treating cancer osseous metastasis. The traditional Chinese medicine composition is prepared from, by weight, 8 parts to 14 parts of cassia twigs, 6 parts to 10 parts of radix paeoniae alba, 6 parts to 10 parts of liquorice, 30 parts to 60 parts of radix clematidis, 8 parts to 14 parts of radix bupleuri, 8 parts to 14 parts of scutellaria baicalensis, 8 parts to 14 parts of pericarpium citri reticulatae, 8 parts to 14 parts of curcuma aromatica, 8 parts to 14 parts of cortex moutan, 8 parts to 14 parts of notopterygium roots, 8 parts to 14 parts of radix angelicae pubescentis, 8 parts to 14 parts of radix saposhnikoviae, 1 part to 5 parts of asarum sieboldii, 8 parts to 14 parts of poria cocos, 8 parts to 14 parts of angelica sinensis, 8 parts to 14 parts of radix achyranthis bidentatae, 8 parts to 14 parts of dipsacus asperoides, 4 parts to 8 parts of rheum officinale, 8 parts to 14 parts of radices ligustici sinensis, 8 parts to 14 parts of chastetree fruits and 8 parts to 14 parts of ligusticum wallichii. The traditional Chinese medicine composition has the obvious inhibiting effect and the obvious repairing effect on various cancer patients, various metastatic tumor patients, various cancer hydrothorax and ascites patients and various osseous metastasis patients, and the anti-tumor mode achieves the positive and beneficial effect on improving the life quality and prolonging the lifetime of tumor patients.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating cancer bone metastasis. Background technique [0002] Bone cancer pain is the most serious type of cancer pain, which mainly originates from primary bone tumors or secondary bone metastases from lung cancer, breast cancer, prostate cancer, etc., seriously affecting the quality of life of cancer patients. Before Schwei et al first reported the bone cancer pain model in mice in 1999, cancer pain research had been conducted on non-cancer-induced chronic pain models. In fact, the pathogenesis of the two is not the same, and drugs that are effective in the treatment of neuropathic pain cannot relieve cancer pain. In recent years, different tumor cells have been inoculated into the bone marrow cavity of the tibia by local injection, and a tibial cancer pain model has been successfully established. This model can be regarded as a metastati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K31/4709A61P35/04
Inventor 陈国军
Owner 陈国军
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