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Application of resolvin D1 as an antiepileptic drug

An anti-epileptic drug and anti-epileptic technology, applied in the field of biomedicine

Inactive Publication Date: 2019-01-11
THE FIRST AFFILIATED HOSPITAL OF XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether Resolvin D1 has a protective effect on brain tissue damage caused by epilepsy has not been reported at home and abroad.

Method used

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  • Application of resolvin D1 as an antiepileptic drug
  • Application of resolvin D1 as an antiepileptic drug
  • Application of resolvin D1 as an antiepileptic drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The present invention will be described in detail below in combination with specific embodiments.

[0018] The invention relates to the brain protection effect and mechanism of 3 μg / kg Resolvin D1 on epileptic rats. The Resolvin D1 has anti-epileptic effect on epileptic rats induced by lithium chloride pilocarpine, and has anti-inflammatory response properties. The mechanism may be to significantly increase DEL1 expression, reduce IL-17 content and other ways to reduce inflammation in epileptic rats Response, resulting in brain protection in epileptic rats.

[0019] Resolvin D1 has anti-inflammatory and anti-epileptic effects experiments:

[0020] 1. Case (sample) selection method:

[0021] Human cerebrospinal fluid and serum: A total of 35 patients who met the inclusion criteria and were admitted to the Neurology Department of the First Affiliated Hospital of Xi'an Medical College from December 2013 to December 2014 were collected and divided into an epilepsy group o...

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PUM

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Abstract

The invention relates to application of Resolvin D1 as antiepileptic drugs. Resolvin D1 has high-efficiency inflammation resistance and inflammation absorption promotion effects, but currently no relevant reports are seen at home and abroad for whether Resolvin D1 has an effect on protecting brain tissue against damage caused by epilepsy or not. According to the application of Resolvin D1 as epilepsy treating drugs, Resolvin D1 serves as anti-inflammation and antiepileptic drugs by adding expression of endogenous anti-adhesion molecules DEL-1 and reducing the content of IL-17.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of Resolvin D1 as an antiepileptic drug. Background technique [0002] Epilepsy is the second most common disease of the nervous system after stroke. About 50 million people in the world suffer from epilepsy, and there are more than 9 million epilepsy patients in my country, with more than 400,000 new cases each year. The treatment of epilepsy still takes drugs as the main means. Among them, traditional antiepileptic drugs include phenytoin, carbamazepine, valproic acid, phenobarbital, primidone, ethosuximide, and clonazepam; Epilepsy drugs include topiramate, lamotrigine, gabapentin, felbamate, oxcarbazepine, vigabatrin, tigabine, zonisamide, levetiracetam, and pregabalin. About 75-80% of patients can be controlled with the above antiepileptic drugs, but there are still 25-30% of epilepsy patients who are ineffective in drug treatment. This not on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/232A61P25/08A61P29/00
Inventor 李亚军孟芳霖
Owner THE FIRST AFFILIATED HOSPITAL OF XIAN MEDICAL UNIV