Pharmaceutical preparation for controlling atherosclerosis and its application

A technology for atherosclerosis and pharmaceutical preparations, applied in the field of medicine, can solve the problems of large surgical trauma, adverse reactions, and unfavorable patient recovery, and achieve the effects of improving the degree of lesions, less toxic and side effects, and obvious curative effects

Inactive Publication Date: 2016-02-24
王丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, atherosclerosis is more likely to occur in the elderly, and the surgical trauma is large, which is not conducive to the recovery of the patient, and the cost of the operation is relatively high.
Western medicines for the treatment of atherosclerosis mainly include the following categories: 1. statins, mainly lipid-lowering drugs that lower triglycerides and low-density lipoproteins; 2. drugs that resist platelet adhesion and aggregation; 3. thrombolytic and Anticoagulant drugs; 4 symptomatic drugs for ischemic symptoms, such as vasodilators and β receptor blockers used in the treatment of angina pectoris; these western drugs often cause adverse reactions, especially not suitable for long-term medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: the preparation of Chinese medicine dry plaster powder

[0015] Weigh 1.2kg of Uncaria vine, 1.2kg of black snake, 1.6kg of dog ridge, 0.9kg of shegan, 0.9kg of saponin thorn, 2.6kg of corn silk, 2.3kg of Speranthema, 0.7kg of Wujiapi and 0.9kg of kelp, add water Decoct twice, add 150L of purified water for the first time, decoct for 2h, add 130L of purified water for the second time, decoct for 1.5h, combine the decoctions, concentrate under reduced pressure at 0.08MPa and 70℃ to 70℃, and the relative density is 1.15, add 95% ethanol to make the alcohol content reach 75% (v / v), stir, let it stand overnight, filter, and concentrate the filtrate under reduced pressure at 0.08MPa and 65°C to obtain a leaching solution with a relative density of 1.25 at 65°C. Paste, the extract is placed in a stainless steel pan, vacuum-dried (below 60°C) to form a dry paste, and crushed.

Embodiment 2

[0016] Embodiment 2: the preparation of Chinese medicine tablet

[0017] Weigh 0.5 kg of Chinese medicine extract dry powder (prepared according to the formula process in Example 1), pass through a 100-mesh sieve, then add 1.3 kg of dextrin and 0.7 kg of microcrystalline cellulose passed through an 80-mesh sieve, mix well, and take an appropriate amount of 75% ethanol solution is used as a binder, and the wet granulation method is adopted, that is, the wet granules are made through a 32-mesh sieve, and the wet granules are fully dried at 45-60°C, and the granules are sized. Add 20g of talc powder to the dry granules, mix well, and directly press Tablets, get Chinese medicine tablets.

Embodiment 3

[0018] Example 3: Study on the Treatment of Chinese Medicine Dry Paste Powder on Atherosclerosis Model Mice

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PUM

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Abstract

The invention discloses a pharmaceutical preparation for controlling atherosclerosis and its application. The preparation comprises an ingredient component and pharmaceutically acceptable auxiliaries. The active ingredient is prepared by means of water extraction and alcohol precipitation from following traditional Chinese medicinal materials in parts by weight: Ramulus Uncariae Cum Uncis 9-15 parts, Zaocys 9-15 parts, Rhizoma Cibotii 12-20 parts, Rhizoma Belamcandae 6-12 parts, Spina Gleditsiae 6-12 parts, Stigmata Maydis 21-33 parts, Herba Speranskiae Tuberculatae 18-30 parts, Cortex Acanthopanacis 5-10 parts, and Thallus Laminariae 6-12 parts. The pharmaceutical preparation of the invention is significantly capable of improving the pathological degree of atherosclerosis and treating both root causes and symptoms with low toxic or side effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical preparation for preventing and treating atherosclerosis and its application. Background technique [0002] Cardiovascular and cerebrovascular diseases are currently the most lethal and disabling diseases, and atherosclerosis (AS) is the main cause of cardiovascular and cerebrovascular diseases, so active prevention and treatment of atherosclerosis can fundamentally reduce the risk of cardiovascular disease. occurrence of cerebrovascular disease. Atherosclerosis is a common clinical vascular disease. Pathological studies have confirmed that various factors lead to the hardening and thickening of the arterial wall, the decrease in elasticity, and the narrowing of the vascular lumen, thereby affecting the blood supply of the brain and limbs, and affecting various parts of the body. In severe cases, it may even lead to loss of limb function or death. C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P9/10A61K35/583
Inventor 王丽
Owner 王丽
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