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Ophthalmic preparation and preparation method and application thereof

An ophthalmic preparation and inhibitor technology, applied in the field of ophthalmic preparations and their preparation, can solve the problems of inconvenient treatment and medication, and achieve the effects of improving the degree of microvascular disease, broad application prospects and simple preparation method.

Inactive Publication Date: 2020-03-24
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the problems of many complications and inconvenient treatment and medication in existing diabetic retinopathy treatment methods, the present invention provides an ophthalmic preparation and its preparation method and application

Method used

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  • Ophthalmic preparation and preparation method and application thereof
  • Ophthalmic preparation and preparation method and application thereof
  • Ophthalmic preparation and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The present embodiment provides a kind of eye drops for the treatment of diabetic retinopathy, and the prescription dosage is shown in the following table:

[0034] Material name Prescription amount Mass concentration (W / V)% t-AUCB 0.25g 0.05％ Polyoxyethylene castor oil 35 25g 5％ Sodium chloride 4.25g 0.85％ Disodium phosphate Appropriate amount Appropriate amount distilled water to 500g —

[0035] The preparation method of the above-mentioned eye drops for the treatment of diabetic retinopathy is as follows:

[0036] Take the prescribed amount of polyoxyethylene castor oil 35, add it to 100g of distilled water, stir until dissolved, add the prescribed amount of sodium chloride, mix well, add the prescribed amount of t-AUCB, after dissolving, adjust the pH with sodium dihydrogen phosphate solution To 7.0, add distilled water to 500g, get the eye drops for the treatment of diabetic retinopathy. The prepared eye drops...

Embodiment 2

[0038] The present embodiment provides a kind of eye drops for the treatment of diabetic retinopathy, and the prescription dosage is shown in the following table:

[0039] Material name Prescription amount Mass concentration (W / V)% t-AUCB 0.25g 0.05％ Polyethylene glycol-12-hydroxystearate 35g 7％ Sodium chloride 4.05g 0.81％ sodium hydroxide Appropriate amount Appropriate amount distilled water to 500g —

[0040] The preparation method of the above-mentioned eye drops for the treatment of diabetic retinopathy is as follows:

[0041] Take the prescribed amount of polyethylene glycol-12-hydroxystearate, add it to 100g of distilled water, stir until dissolved, add the prescribed amount of sodium chloride, mix well, add the prescribed amount of t-AUCB, dissolve, and use hydrogen The sodium oxide solution is adjusted to pH 7.0, and distilled water is added to 500 g to obtain eye drops for treating diabetic retinopathy. The prepa...

Embodiment 3

[0043] The present embodiment provides a kind of eye drops for the treatment of diabetic retinopathy, and the prescription dosage is shown in the following table:

[0044] Material name Prescription amount Mass concentration (W / V)% t-AUCB 0.25g 0.05％ γ-cyclodextrin 50g 10％ Sodium chloride 3.05g 0.61％ Disodium phosphate Appropriate amount Appropriate amount distilled water to 500g —

[0045] The preparation method of the above-mentioned eye drops for the treatment of diabetic retinopathy is as follows:

[0046] Take the prescribed amount of γ-cyclodextrin, add it to 100g of distilled water, stir until dissolved, add the prescribed amount of sodium chloride, mix well, add the prescribed amount of t-AUCB, after dissolving, adjust the pH to 7.0, add distilled water to 500g to get eye drops for treating diabetic retinopathy. The prepared eye drops were placed in an eye drop bottle and stored at 4°C.

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Abstract

The invention relates to the technical field of pharmaceutical preparations, and specifically discloses an ophthalmic preparation and a preparation method and application thereof. The active componentof the ophthalmic preparation provided by the invention is a soluble epoxide hydrolase inhibitor t-AUCB, which can effectively inhibit the expression of soluble epoxide hydrolase (sEH) and reduce theloss of retinal pericytes and improve the degree of microangiopathy, thus achieving the purpose of preventing and treating diabetic retinopathy. The ophthalmic preparation provided by the invention is a clinically-used pharmaceutical preparation, such as eye drops, an ophthalmic ointment or ophthalmic gel, etc., prepared from t-AUCB and pharmaceutically acceptable excipients. Local drug deliveryof eyes is realized, which is beneficial to improve medication compliance of patients. In addition, the preparation method of the ophthalmic preparation is simple, has strong controllability, is beneficial to realize industrial production, and has broad application prospects in the field of diabetic retinopathy prevention and treatment.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an ophthalmic preparation and its preparation method and application. Background technique [0002] Diabetic Retinopathy (DR) is a microvascular disease, one of the most common and serious chronic complications of diabetes, and has become an important cause of blindness worldwide. The basic pathological changes are the destruction of the retinal blood-retinal barrier and the formation of retinal neovascularization, macular edema, and eventually retinal detachment, leading to blindness. At present, the clinical methods used to treat diabetic retinopathy mainly include intravitreal injection of vascular growth factor inhibitors and laser photocoagulation. Intraocular injection of vascular growth factor inhibitors is inconvenient, and frequent intravitreal injections may cause local complications such as uveitis, cataract, retinal detachment, and intraocular inf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/196A61K9/00A61P3/10A61P27/02A61P9/10
CPCA61K31/196A61K9/0048A61K47/44A61P3/10A61P27/02A61P9/10
Inventor 高子彬张福云张国刚孟思臧香环付玉飞黄德胜李玲玲霍月香李硕张惠敏孙艳平孙勇军
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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